Peptide-Based Formulations for Skin Barrier Restoration

Bioactive peptide for repairing skin wounds and formulations containing it. The peptide sequence is ELGDCSRALKIYFPVTWNCYGMAHR. It can be used in cosmetics to promote skin wound healing and in medicines to treat skin wounds. The peptide promotes capillary formation during wound healing by increasing expression of growth factors like VEGF.

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Peptides that enhance cell-cell and cell-matrix adhesion in the epidermis, particularly in the dermal-epidermal junction. The peptides contain specific amino acid sequences that promote the formation of stable adhesion structures between keratinocytes and the basal lamina, facilitating tissue regeneration and repair. These peptides can be used to treat skin aging and other dermatological conditions by strengthening the skin's structural integrity and promoting epidermal regeneration.

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A transdermal delivery system for bioactive peptides that significantly enhances skin penetration and bioavailability. The system comprises a skin-penetrating peptide with specific amino acid sequences, which is engineered to interact with skin barriers. This peptide, when applied in a transdermal formulation, enables controlled delivery of bioactive peptides through the skin's natural barriers, bypassing the conventional limitations of low molecular weight substances. The system can be used to treat various skin conditions, including wound healing, anti-aging, and inflammatory diseases, through targeted delivery of bioactive peptides.

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New uses of pentapeptides in skin and mucous membrane care to restore function, promote regeneration, heal wounds, improve cell adhesion, increase collagen production, and enhance skin elasticity and firmness. The pentapeptides are Palm-Lys-Val-Lys-Leu-Tyr-NH2 and Palm-Lys-Val-Lys-Leu-Tyr-OH. They can be administered topically in creams, lotions, gels, or sprays to address signs of aging, tighten skin, improve elasticity, and promote wound healing.

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Polypeptides with novel structures that promote skin regeneration and repair through enhanced collagen production and skin elasticity. The peptides target key skin aging pathways, including oxidative stress, collagen degradation, and cell adhesion, to restore skin integrity and firmness. By modulating these pathways, the peptides improve skin elasticity, reduce wrinkles, and enhance skin firmness, making them suitable for skin care formulations to address aging and damage.

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A cell-penetrating peptide for delivering active ingredients into skin cells to improve their efficacy in skin health care products. The peptide sequence is NYBX1BX2BNQX3, where X1 is tryptophan, phenylalanine, tyrosine, or alanine, X2 is cysteine, and X3 is asparagine or absent. The peptide can be used alone or combined with active substances like antioxidants and collagen stimulators to enhance their uptake into skin cells. This allows deeper penetration and activity of skin care actives compared to traditional topical application methods.

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A peptide compound that enhances skin barrier function and immune regulation, particularly for repairing skin immunity. The compound, with a specific structure, specifically targets and stabilizes skin barrier proteins while modulating immune cell function. It has been shown to improve skin barrier integrity and promote immune cell function, particularly in response to environmental stressors. The compound has been evaluated for its anti-inflammatory and immunomodulatory effects, with potential applications in skin care products.

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A peptide that promotes skin barrier repair by enhancing keratinocyte proliferation, migration, and differentiation. The peptide, designated HCSP4, specifically targets the epidermal differentiation complex (EDC) and has been shown to accelerate the repair of damaged skin barriers through its ability to stimulate keratinocyte proliferation and migration. The peptide's therapeutic effects are demonstrated in both in vitro and in vivo models, particularly in the context of skin barrier damage.

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A bioactive peptide that enhances epithelial cell proliferation and accelerates skin repair through its antioxidant properties. The peptide, derived from adipose stem cells, promotes epithelial cell growth while neutralizing oxidative stress. This peptide is combined with adipose-derived exosomes, which contain stem cell secreted factors, to deliver the bioactive compound to the skin. The peptide's antioxidant activity is demonstrated through its ability to scavenge hydroxyl radicals, a key contributor to skin aging and damage. The peptide and exosomes formulation enables targeted delivery of the bioactive compound to the skin, promoting epithelial cell proliferation and skin repair while maintaining skin health.

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Peptide-based treatments for skin aging and damage, particularly in the context of epidermal junction integrity and cell-matrix adhesion. The peptides, specifically CSGLRIRATYGSGC, exhibit enhanced wound healing and tissue repair capabilities through their ability to promote cell-cell and cell-matrix adhesion. These treatments can be used in combination with conventional skin care products to address various skin conditions, including wrinkles, sagging, and loss of skin elasticity.

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Cosmetic formulations that deliver erythropoietin-derived peptides to targeted skin cells through targeted delivery systems. The formulations utilize peptide conjugates with specific targeting capabilities, enabling controlled delivery to skin cells while maintaining their biological activity. These conjugates can be formulated as lotions or creams with varying lipid content, allowing optimal skin penetration and absorption. The peptides themselves contain tissue-protective and regenerative properties, including vasodilation and anti-inflammatory effects, making them suitable for treating skin damage and imperfections.

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Skin-penetrating peptides that enhance delivery of biologically active molecules through the skin barrier. The peptides, derived from natural peptides like antennapedia homeoprotein, have improved skin penetration properties compared to conventional peptides. These peptides can be fused with therapeutic agents to enhance their delivery across the skin barrier, particularly for treatments requiring high concentrations of active ingredients. The peptides' enhanced penetration enables more effective therapeutic delivery, particularly for dermatological conditions requiring high concentrations of active ingredients.

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A biologically active peptide with enhanced skin repair properties, particularly for anti-aging and anti-inflammatory applications. The peptide, designated as EQ-9, exhibits superior efficacy compared to its precursor, LQ-17, in promoting collagen synthesis, protecting against UV-induced damage, and enhancing cellular viability. EQ-9's structural modifications enable improved stability, reduced production costs, and enhanced skin penetration compared to its precursor. The peptide's biological activity is demonstrated through cell viability assays, UVA damage repair experiments, and collagen synthesis studies.

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A novel delivery system for bioactive peptides that significantly enhances their transdermal penetration through the skin barrier. The system utilizes a skin-permeable peptide or its fragments, which are engineered to penetrate the skin barrier through specific molecular mechanisms. This peptide-based delivery system enables the controlled release of bioactive peptides across the skin surface, overcoming the limitations of conventional peptide delivery methods. The system can be formulated into various cosmetic and pharmaceutical applications, including transdermal patches, creams, and liposomes, to deliver bioactive peptides for skin health and therapeutic applications.

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Strengthening the skin barrier or inhibiting skin itchiness to improve skin aging and skin wrinkles. The peptide is released by epidermal cells and has an activity of suppressing itch-inducing factors, thus strengthening the skin barrier, inhibiting skin aging, skin wrinkles It can be usefully used for inhibiting formation or inhibiting itching.

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Polypeptide composition for anti-inflammatory, soothing, and repairing sensitive skin. The composition contains active peptides like acetyl heptapeptide-4, oligopeptide-1, palmitoyl tripeptide-8, palmitoyl tetrapeptide-7, and heptapeptide-6, along with moisturizing agents, emollients, and a thickening agent made from starch derivatives. The starch derivatives are obtained by modifying stevia starch with a cross-linking agent. Adding plant extracts like paeoniflorin and vanillin methyl ether further enhances the anti-inflammatory, allergy-relieving, and skin barrier repairing properties.

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Using cell-penetrating peptides to enhance the efficacy of skin care active ingredients like antioxidants and collagen stimulators. The peptides are designed to transport these compounds across the skin barrier into cells. This allows them to provide their intended benefits inside the cells instead of being trapped on the surface. The peptides are combined with the active ingredients to create skin care products that can deliver the actives deeper into the skin for improved efficacy.

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Short-chain peptide composition for skin protection with efficacy in promoting skin regeneration, wound healing, moisturizing, and elasticity. The composition contains short peptides with 5-10 amino acids, including serine and lysine. The peptides have molecular weight 550-1100 Da. They promote skin cell proliferation, wound repair, moisturization, and elasticity. The peptides can be used in skin care products to enhance skin health and repair.

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Peptide-based compositions and formulations for treating wounds, aging skin, and skin conditions. The compositions contain peptides derived from angiopoietin-1, such as QHREDGS. Applying these peptide formulations to the skin promotes wound healing, reduces scars, and improves skin texture and appearance. The peptides can be delivered in topical formulations, patches, scaffolds, or bandages.

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Cosmetic composition for improving skin troubles caused by mask use and other skin irritation. The composition contains peptides like copper tripeptide-1, hexapeptide-22 dimer, and acetyltetrapeptide-15. These peptides promote skin barrier recovery, wound healing, and regeneration. The composition can be used as a lotion, emulsion, gel, cream, essence, pack, ampoule, cleanser, soap, body product, oil, lipstick, or foundation to soothe and regenerate irritated skin from mask wear. The peptides are combined with conventional cosmetic ingredients like antioxidants, stabilizers, solubilizers, vitamins, pigments, fragrances, carriers, surfactants, moisturizers, preservatives, and antioxidants.

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Peptide compounds for improving the appearance and general condition of skin and hair by stimulating synthesis of extracellular matrix proteins like collagen, elastin, fibronectin, laminin, and hyaluronic acid. The peptides contain amino acids with rings or heterocycles grafted onto the side chain nitrogen via peptide bonds. Examples include compounds like oPal-K(P)-HG-OH and Pal-K(Pyr)-GH-OH. These peptides can be used alone or in combination at low ppm concentrations in cosmetic compositions for benefits like anti-aging, wrinkle reduction, firmness, density, volume, moisturization, and uniformity.

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Skin repair peptide for wound healing applications that can be used in skin damage repair drugs and cosmetics. The peptide, TYL (KCWRWKRWCK), has a unique amino acid sequence with optimized hydrophobicity to enable uniform dispersion in both water and oil. This allows stable formulations for cosmetics and pharmaceuticals. The peptide promotes wound healing by increasing macrophage recruitment, myofibroblast activation, and collagen synthesis.

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Polypeptide composition for repairing sensitive skin, comprising tripeptide-1, palmitoyl tetrapeptide-7, palmitoyl tripeptide-8, and acetyl dipeptide-1 whale wax ester, at concentrations of 0.05-1% in a formulation that balances skin penetration and stability.

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A peptide called AEC1D, consisting of six amino acids, for promoting skin regeneration and wound healing. The peptide enhances collagen synthesis and fibroblast activation to accelerate wound healing and improve skin regeneration. It can be used as a therapeutic for acne wounds and other skin damage, as well as in cosmetics and health supplements for wound healing and skin regeneration.

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A novel cell-permeable peptide that enhances skin penetration and therapeutic delivery of active ingredients. The peptide, which has improved skin penetration properties compared to conventional cell-penetrating peptides, exhibits multifunctional skin benefits including whitening, wrinkle reduction, antioxidant activity, anti-aging, and hair growth promotion. The peptide forms stable complexes with active ingredients, enhancing their delivery and efficacy in skin treatments.

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A short peptide called Purin-WH that promotes skin repair and regeneration. The peptide sequence is Val-Val-Pro-Thr-Val-Val-Cys-Pro-Lys. It has low molecular weight, high activity, and low toxicity. Purin-WH improves wound healing, reduces scarring, and has potential applications in skin repair drugs, cosmetics, and food additives. The peptide can be synthesized using standard techniques and has low hemolytic activity.

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Peptide AESIS-1P3 for skin regeneration and wound healing, with therapeutic applications in dermatology and cosmetic treatments. The peptide is a novel growth factor with enhanced wound healing properties compared to existing treatments, particularly in cases of chronic wounds and psoriasis. The peptide's mechanism of action involves promoting cellular proliferation, differentiation, and tissue regeneration, while also inhibiting fibrosis and inflammation. Its therapeutic potential is demonstrated through in vitro and in vivo studies, with specific applications in wound care, skin rejuvenation, and cosmetic treatments.

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Peptide AES11-1 for skin regeneration and wound healing. The peptide, consisting of three amino acids, promotes fibroblast activity, collagen synthesis, and skin regeneration. It can be used in pharmaceutical compositions, cosmetics, and health foods to treat wounds, ulcers, dermatitis, and acne. The peptide may also be administered as a therapy for skin regeneration.

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A peptide TVigour A that promotes fibroblast proliferation and inhibits scar cell proliferation, with enhanced transdermal delivery. TVigour A is a naturally occurring peptide with a unique sequence that selectively targets fibroblasts while inhibiting scar cells, thereby enhancing tissue repair. The peptide achieves this through its ability to interact with specific fibroblast receptors, while also promoting the transdermal delivery of active molecules. TVigour A has been shown to enhance wound healing by promoting fibroblast proliferation and inhibiting scar cell proliferation, with enhanced transdermal delivery compared to traditional wound dressings.

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A skin permeable peptide that enables the delivery of biologically active molecules through the skin barrier. The peptide, derived from human ASTN1 protein, exhibits remarkable transdermal permeability, allowing it to penetrate the skin's stratum corneum and intercellular spaces. This peptide can be combined with biologically active substances to create effective delivery systems for therapeutic agents, particularly those with low molecular weights. The peptide's unique properties enable efficient transdermal delivery through the skin, particularly in the stratum corneum, making it an ideal candidate for topical treatments.

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Peptide exhibiting enhanced skin condition improvement and regeneration properties, comprising a polynucleotide encoding the peptide, a polynucleotide encoding the peptide, and a cosmetic and health functional food composition containing the peptide. The peptide improves skin condition and regeneration through its specific biological activity, and the composition provides improved skin condition and regeneration benefits through the peptide.

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A peptide that promotes tissue repair and regeneration through its ability to enhance cellular proliferation and migration in wound sites, particularly in skin damage and nerve damage. The peptide, derived from a phage peptide library screen, contains 4-15 amino acid sequences that interact with fibroblast growth factor receptor 2 (FGFR2) to stimulate cellular processes critical for tissue repair. This peptide has been shown to promote keratinocyte proliferation, fibroblast migration, and granulation tissue formation, while also supporting nerve regeneration and recovery. The peptide's mechanism of action involves activating FGFR2 signaling pathways, which are essential for cell proliferation, migration, and tissue repair.

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A decapeptide exhibiting enhanced skin permeability and stability, with improved skin regeneration properties compared to natural EGF. The peptide sequence, with specific amino acid substitutions and protecting groups, achieves superior stability and skin permeability through its unique structure. This peptide can be used in cosmetic formulations to enhance skin regeneration, improve skin elasticity, and prevent skin aging, while maintaining its growth factor activity.

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Peptides with skin condition improving activity and uses thereof, such as compositions for improving skin condition, pharmaceutical compositions for preventing or treating MMP-activity-related diseases, and pharmaceutical compositions for preventing or treating inflammatory diseases. The peptides have sequences SEQ ID Nos. 1 and 2 and can inhibit matrix metalloproteinase (MMP) enzymes involved in skin aging, wrinkles, inflammation, cancer invasion, and metastasis. They also promote skin cell proliferation and collagen synthesis. The peptides could be used to develop improved therapies for diseases related to MMP overactivity and inflammation.

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Peptides that enhance wound healing by promoting keratinocyte migration and proliferation. The peptides, with specific sequences such as MGRN, KMGRN, or EKMG, have been identified to specifically target the keratinocyte migration and proliferation pathways, thereby facilitating the formation of a single layer of epithelial cells over the wound site. These peptides can be administered directly to wounds, particularly those involving skin and mucosal tissues, for a duration of treatment.

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Peptides that stimulate hyaluronic acid production in human skin, particularly for improving skin appearance and health. The peptides, comprising the sequence AECK (Ala-Glu-Cys-Lys), AEC (Aspartic acid, Glutamic acid, Cysteine), or ECK (Ethyl lysine, Cysteine, Glutamic acid), promote HA synthesis when applied topically to affected skin areas. These peptides enhance skin hydration, tissue repair, and elasticity, leading to improved skin texture, reduced fine lines and wrinkles, and enhanced skin firmness. The peptides can be used in combination with retinoids and alpha-hydroxy acids to enhance their anti-aging effects.

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Peptides that promote proliferation of human skin keratinocyte stem cells for applications in cosmetics and pharmaceuticals. The peptides, Acetyl-Phe-His-Arg-NH2 (peptide 1) and Acetyl-Phe-His-Arg-Trp-NH2 (peptide 2), significantly increase proliferation of keratinocyte stem cells in vitro without toxicity. They also enhance expression of growth factors like FGF-4, FGF-6, FGF-7, IGFBP-2, IGFBP-3, and IGFBP-4. These peptides could be used as agents in cosmetics to improve skin moisturization, elasticity, wrinkles, and aging, or in pharmaceuticals to promote wound healing.

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Peptides for improving skin condition by inhibiting skin cell death, increasing collagen production, and suppressing inflammation. The peptides are sequences SEQ ID NOS: 1, 2, 3, and 4. They have antioxidant activity, prevent UV-induced skin aging, reduce wrinkles, promote wound healing, and alleviate inflammatory skin diseases. The peptides can be used in cosmetic compositions to improve skin condition.

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A skin permeable peptide that enables effective transdermal delivery of therapeutic agents through the skin barrier. The peptide, derived from human ASTN1 protein, achieves remarkable skin penetration despite its molecular weight, making it a superior candidate for delivering therapeutic agents through the skin compared to conventional low-molecular-weight compounds. The peptide enhances skin permeability through a novel mechanism involving cell membrane interactions, while the therapeutic agent can be delivered through the skin barrier. The peptide formulation can be used in various cosmetic and pharmaceutical applications to treat skin conditions.

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Peptide with enhanced skin regeneration properties, derived from natural sources, that mimics the biological activity of EGF (Epidermal Growth Factor) while maintaining stability and skin permeability. This peptide, engineered to overcome the limitations of EGF, enables sustained cell proliferation and collagen synthesis in the skin, contributing to improved skin regeneration and tissue repair.

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A cosmetic composition for skin repair that combines a proprietary blend of ingredients to promote epithelial cell proliferation, collagen synthesis, and skin barrier recovery. The composition contains a balanced ratio of water, glycerin, propylene glycol, collagen cross-linking agent, oligopeptide-1, oligopeptide-2, and oligonucleotides, which work synergistically to enhance skin regeneration and repair processes.

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A wound-healing composition comprising a specific peptide fragment derived from the epidermal growth factor (EGF) that activates the epidermal growth factor receptor, promotes keratinocyte proliferation, and enhances angiogenesis. The peptide, with its unique sequence, exhibits potent wound healing properties through its ability to stimulate keratinocyte proliferation and promote angiogenesis, while also inhibiting matrix metalloproteinases that degrade the extracellular matrix.

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Peptides with sequences SEQ ID Nos 1-4 that improve skin conditions by reducing oxidative stress, inhibiting cell death, increasing collagen production, and suppressing inflammation. Applications include skincare compositions containing these peptides for improving skin elasticity, anti-wrinkle effects, wound healing, sun protection, and inflammatory skin disease treatment. The peptides can be synthesized and used in cosmetic formulations at effective amounts.

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Peptide for cosmetic and pharmaceutical applications that activates human transglutaminase enzymes to reinforce skin barrier function, stimulate epidermal regeneration, and combat skin aging. The peptide is of general formula R1-(AA)n-X1-X2-Arg-Arg-Gly-X3-X4-(AA)p-R2. It can be used alone or in combination with other active ingredients in compositions like creams, lotions, shampoos, and oral preparations. The peptide protects skin against external stresses like UV, pollution, and irritants. It also improves skin healing and reduces signs of aging like wrinkles and rough patches.

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