Peptide-Based Formulations for Skin Barrier Restoration

Bioactive peptide for repairing skin wounds and formulations containing it. The peptide sequence is ELGDCSRALKIYFPVTWNCYGMAHR. It can be used in cosmetics to promote skin wound healing and in medicines to treat skin wounds. The peptide promotes capillary formation during wound healing by increasing expression of growth factors like VEGF.

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Peptides that enhance cell-cell and cell-matrix adhesion in the epidermis, particularly in the dermal-epidermal junction. The peptides contain specific amino acid sequences that promote the formation of stable adhesion structures between keratinocytes and the basal lamina, facilitating tissue regeneration and repair. These peptides can be used to treat skin aging and other dermatological conditions by strengthening the skin's structural integrity and promoting epidermal regeneration.

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A transdermal delivery system for bioactive peptides that significantly enhances skin penetration and bioavailability. The system comprises a skin-penetrating peptide with specific amino acid sequences, which is engineered to interact with skin barriers. This peptide, when applied in a transdermal formulation, enables controlled delivery of bioactive peptides through the skin's natural barriers, bypassing the conventional limitations of low molecular weight substances. The system can be used to treat various skin conditions, including wound healing, anti-aging, and inflammatory diseases, through targeted delivery of bioactive peptides.

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New uses of pentapeptides in skin and mucous membrane care to restore function, promote regeneration, heal wounds, improve cell adhesion, increase collagen production, and enhance skin elasticity and firmness. The pentapeptides are Palm-Lys-Val-Lys-Leu-Tyr-NH2 and Palm-Lys-Val-Lys-Leu-Tyr-OH. They can be administered topically in creams, lotions, gels, or sprays to address signs of aging, tighten skin, improve elasticity, and promote wound healing.

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Polypeptides with novel structures that promote skin regeneration and repair through enhanced collagen production and skin elasticity. The peptides target key skin aging pathways, including oxidative stress, collagen degradation, and cell adhesion, to restore skin integrity and firmness. By modulating these pathways, the peptides improve skin elasticity, reduce wrinkles, and enhance skin firmness, making them suitable for skin care formulations to address aging and damage.

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A cell-penetrating peptide for delivering active ingredients into skin cells to improve their efficacy in skin health care products. The peptide sequence is NYBX1BX2BNQX3, where X1 is tryptophan, phenylalanine, tyrosine, or alanine, X2 is cysteine, and X3 is asparagine or absent. The peptide can be used alone or combined with active substances like antioxidants and collagen stimulators to enhance their uptake into skin cells. This allows deeper penetration and activity of skin care actives compared to traditional topical application methods.

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A peptide compound that enhances skin barrier function and immune regulation, particularly for repairing skin immunity. The compound, with a specific structure, specifically targets and stabilizes skin barrier proteins while modulating immune cell function. It has been shown to improve skin barrier integrity and promote immune cell function, particularly in response to environmental stressors. The compound has been evaluated for its anti-inflammatory and immunomodulatory effects, with potential applications in skin care products.

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A peptide that promotes skin barrier repair by enhancing keratinocyte proliferation, migration, and differentiation. The peptide, designated HCSP4, specifically targets the epidermal differentiation complex (EDC) and has been shown to accelerate the repair of damaged skin barriers through its ability to stimulate keratinocyte proliferation and migration. The peptide's therapeutic effects are demonstrated in both in vitro and in vivo models, particularly in the context of skin barrier damage.

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A bioactive peptide that enhances epithelial cell proliferation and accelerates skin repair through its antioxidant properties. The peptide, derived from adipose stem cells, promotes epithelial cell growth while neutralizing oxidative stress. This peptide is combined with adipose-derived exosomes, which contain stem cell secreted factors, to deliver the bioactive compound to the skin. The peptide's antioxidant activity is demonstrated through its ability to scavenge hydroxyl radicals, a key contributor to skin aging and damage. The peptide and exosomes formulation enables targeted delivery of the bioactive compound to the skin, promoting epithelial cell proliferation and skin repair while maintaining skin health.

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Peptide-based treatments for skin aging and damage, particularly in the context of epidermal junction integrity and cell-matrix adhesion. The peptides, specifically CSGLRIRATYGSGC, exhibit enhanced wound healing and tissue repair capabilities through their ability to promote cell-cell and cell-matrix adhesion. These treatments can be used in combination with conventional skin care products to address various skin conditions, including wrinkles, sagging, and loss of skin elasticity.

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Cosmetic formulations that deliver erythropoietin-derived peptides to targeted skin cells through targeted delivery systems. The formulations utilize peptide conjugates with specific targeting capabilities, enabling controlled delivery to skin cells while maintaining their biological activity. These conjugates can be formulated as lotions or creams with varying lipid content, allowing optimal skin penetration and absorption. The peptides themselves contain tissue-protective and regenerative properties, including vasodilation and anti-inflammatory effects, making them suitable for treating skin damage and imperfections.

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Skin-penetrating peptides that enhance delivery of biologically active molecules through the skin barrier. The peptides, derived from natural peptides like antennapedia homeoprotein, have improved skin penetration properties compared to conventional peptides. These peptides can be fused with therapeutic agents to enhance their delivery across the skin barrier, particularly for treatments requiring high concentrations of active ingredients. The peptides' enhanced penetration enables more effective therapeutic delivery, particularly for dermatological conditions requiring high concentrations of active ingredients.

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A biologically active peptide with enhanced skin repair properties, particularly for anti-aging and anti-inflammatory applications. The peptide, designated as EQ-9, exhibits superior efficacy compared to its precursor, LQ-17, in promoting collagen synthesis, protecting against UV-induced damage, and enhancing cellular viability. EQ-9's structural modifications enable improved stability, reduced production costs, and enhanced skin penetration compared to its precursor. The peptide's biological activity is demonstrated through cell viability assays, UVA damage repair experiments, and collagen synthesis studies.

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A novel delivery system for bioactive peptides that significantly enhances their transdermal penetration through the skin barrier. The system utilizes a skin-permeable peptide or its fragments, which are engineered to penetrate the skin barrier through specific molecular mechanisms. This peptide-based delivery system enables the controlled release of bioactive peptides across the skin surface, overcoming the limitations of conventional peptide delivery methods. The system can be formulated into various cosmetic and pharmaceutical applications, including transdermal patches, creams, and liposomes, to deliver bioactive peptides for skin health and therapeutic applications.

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Strengthening the skin barrier or inhibiting skin itchiness to improve skin aging and skin wrinkles. The peptide is released by epidermal cells and has an activity of suppressing itch-inducing factors, thus strengthening the skin barrier, inhibiting skin aging, skin wrinkles It can be usefully used for inhibiting formation or inhibiting itching.

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Polypeptide composition for anti-inflammatory, soothing, and repairing sensitive skin. The composition contains active peptides like acetyl heptapeptide-4, oligopeptide-1, palmitoyl tripeptide-8, palmitoyl tetrapeptide-7, and heptapeptide-6, along with moisturizing agents, emollients, and a thickening agent made from starch derivatives. The starch derivatives are obtained by modifying stevia starch with a cross-linking agent. Adding plant extracts like paeoniflorin and vanillin methyl ether further enhances the anti-inflammatory, allergy-relieving, and skin barrier repairing properties.

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Using cell-penetrating peptides to enhance the efficacy of skin care active ingredients like antioxidants and collagen stimulators. The peptides are designed to transport these compounds across the skin barrier into cells. This allows them to provide their intended benefits inside the cells instead of being trapped on the surface. The peptides are combined with the active ingredients to create skin care products that can deliver the actives deeper into the skin for improved efficacy.

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Short-chain peptide composition for skin protection with efficacy in promoting skin regeneration, wound healing, moisturizing, and elasticity. The composition contains short peptides with 5-10 amino acids, including serine and lysine. The peptides have molecular weight 550-1100 Da. They promote skin cell proliferation, wound repair, moisturization, and elasticity. The peptides can be used in skin care products to enhance skin health and repair.

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Peptide-based compositions and formulations for treating wounds, aging skin, and skin conditions. The compositions contain peptides derived from angiopoietin-1, such as QHREDGS. Applying these peptide formulations to the skin promotes wound healing, reduces scars, and improves skin texture and appearance. The peptides can be delivered in topical formulations, patches, scaffolds, or bandages.

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Cosmetic composition for improving skin troubles caused by mask use and other skin irritation. The composition contains peptides like copper tripeptide-1, hexapeptide-22 dimer, and acetyltetrapeptide-15. These peptides promote skin barrier recovery, wound healing, and regeneration. The composition can be used as a lotion, emulsion, gel, cream, essence, pack, ampoule, cleanser, soap, body product, oil, lipstick, or foundation to soothe and regenerate irritated skin from mask wear. The peptides are combined with conventional cosmetic ingredients like antioxidants, stabilizers, solubilizers, vitamins, pigments, fragrances, carriers, surfactants, moisturizers, preservatives, and antioxidants.

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