Malassezia Growth Inhibition Using Medium-Chain Fatty Acid Derivatives
Malassezia species colonize human skin at densities of 104-106 cells/cm2, with particularly high concentrations in sebum-rich areas. The lipophilic nature of these fungi enables them to metabolize medium-chain fatty acids (C8-C14), producing byproducts that can trigger inflammatory cascades and disrupt skin barrier function when fungal populations exceed normal thresholds.
The challenge lies in selectively controlling Malassezia proliferation while preserving beneficial microflora and maintaining the skin's natural lipid balance.
This page brings together solutions from recent research—including plant extract formulations containing phenolic acids and flavonoids, specialized surfactant systems with caprylic derivatives, scalp microecology stabilizers, and azelaic acid/zinc salt combinations. These and other approaches offer practical strategies for formulating personal care products that effectively manage Malassezia-associated conditions without compromising scalp health.
1. Scalp and Hair Care Composition with Plant Extract Blend Containing Phenolic Acids and Flavonoids
SHANGHAI SONGHAO BIOTECHNOLOGY CO LTD, 2024
Oil controlling, soothing, antibacterial and antioxidant composition for scalp and hair care. The composition contains a plant extract blend, water, antibacterial agent, and auxiliary agent. The plant extracts are from Tremella, Taraxacum Herba, Sophora Flavescentis, Cirsium japonicum, Semen Cassiae, and Herba Oleraceae. The extracts contain phenolic acids and flavonoids with antioxidant and scalp benefits. The composition provides oil control, scalp soothing, antibacterial, and antioxidant properties for scalp and hair care.
2. Shampoo Formulation with Surfactant Blend, Glycosides, Soapberry Peel Extract, Essential Oils, GENTIANA SCABRA Root Extract, Zinc, Salicylic Acid, and Keratin
GUANGZHOU BIROU BIOTECHNOLOGY CO LTD, 2024
Shampoo formulation for dandruff, itchiness, and oil control that combines natural ingredients to address the underlying causes of these scalp conditions. The formulation comprises a surfactant blend, glycosides, soapberry peel extract, essential oils, salt, GENTIANA SCABRA root extract, zinc, salicylic acid, and keratin. The surfactant blend provides cleansing properties, while the glycosides enhance moisturizing and anti-inflammatory effects. The soapberry peel extract and GENTIANA SCABRA root extract contribute to the shampoo's anti-dandruff and itchiness properties, respectively. The zinc and salicylic acid components help control fungal growth and promote scalp health. The formulation balances pH, moisture, and surfactant levels for optimal hair care.
3. Scalp Microecology Stabilizer with Hydrolyzed Chitin, Hydrolyzed Corn Starch, Quaternary Ammonium Salt, Bifid Yeast Fermentation Product, Panthenol, and Zanthoxylum Fruit Extract
Dongping Jiuxin Biochemical Co., Ltd., South China Institute of Collaborative Innovation, Shandong Jiuxin Daily Chemical Co., Ltd., 2024
Scalp microecology stabilizer for hair care products that improves scalp health and reduces issues like dandruff, itching, redness, and pimples. The stabilizer contains specific ingredients like hydrolyzed chitin, hydrolyzed corn starch, quaternary ammonium salt, bifid yeast fermentation product, panthenol, and Zanthoxylum fruit extract. These ingredients promote a balanced scalp microbiome to prevent imbalances that lead to scalp problems. The stabilizer is added to hair care formulations to enhance scalp health and reduce scalp issues compared to regular products.
4. Scalp Care Composition with Azelaic Acid, Zinc Salt, and Pyridoxine in Specific Ratio
LAF JAHWA CO LTD, 2024
A low-dose oil-controlling and allergy-relieving composition for scalp care that balances oil regulation with gentle irritation control. The composition combines azelaic acid, zinc salt, and pyridoxine in a specific ratio, with concentrations optimized for effective oil reduction while minimizing scalp irritation. This formulation addresses the complex balance of scalp oil production and maintenance through a synergistic combination of anti-inflammatory and anti-sebum-regulating agents.
5. Cosmetic Composition with Tiantai Wuyao, Albizia Julibrissin, and Japanese Chestnut Extracts
Derma Skin Research Company, Cosmax Co., Ltd., COSMECCA KOREA CO LTD, 2024
Cosmetic composition for improving scalp condition, comprising Tiantai Wuyao, Albizia Julibrissin, and Japanese Chestnut composite extracts as active ingredients. The composition demonstrates antibacterial, antioxidant, and anti-sebum secretion properties, while maintaining scalp pH and reducing scalp heat. The extracts exhibit synergistic antibacterial activity against Malassezia furfur, while their antioxidant properties protect against oxidative stress and damage. This composition provides effective scalp health benefits through its natural extracts, making it suitable for shampoos, conditioners, and skin lotions.
6. Scalp Care Composition with Plant Extracts and Chelating Agent Featuring Variable Amplitude Depth Profile
WANXIANG ZENG, 2023
A scalp care composition and preparation method that enhances scalp microecology through the synergistic action of plant extracts and a specific chelating agent. The composition comprises a combination of plant extracts, including Lactobacillus casei/Moringa seed fermentation product and tea extract, and a chelating agent like disodium EDTA. The composition is formulated with a humectant, emulsifier, and other ingredients to create a balanced scalp environment that promotes healthy hair growth and reduces scalp irritation. The composition's ability to regulate the scalp microbiome is demonstrated through its capacity to inhibit pathogenic bacteria while maintaining the natural balance of Propionibacterium acnes and Staphylococcus epidermidis.
7. Plant Extract Composition with Specific Proportions of Camellia Oleifera Seed, Tea Bran Polysaccharide, Citrus Peel, Eucalyptus Leaf, and Sophora Flavescens
Guangzhou Degoo Personal Care Products Co., Ltd., GUANGZHOU DEGU PERSONAL-CARE SUPPLY CO LTD, 2022
A plant extract composition for scalp care that combines multiple anti-dandruff and oil-controlling mechanisms. The composition comprises 20-40% Camellia oleifera seed extract, 15-25% tea bran polysaccharide, 10-30% citrus peel extract, 10-30% eucalyptus leaf extract, and 1-20% Sophora flavescens extract. The composition is formulated with 5% ethanol, 3% butanediol, 2% glycerin, and 10% of the extract, with additional ingredients like panthenol, niacinamide, allantoin, lactic acid, peppermint oil, menthol, biotin, and sodium benzoate. The composition provides effective oil control and anti-dandruff benefits through its unique combination of natural compounds.
8. Shampoo Composition with Hydrolyzed Chitin, Matrine, and Pyridoxine Hydrochloride
GUANGZHOU KEEN COSMETIC SCIENT RESEARCH CO, 2022
A shampoo composition that combines anti-dandruff and antipruritic properties with enhanced scalp health. The composition comprises a synergistic blend of hydrolyzed chitin, matrine, and pyridoxine hydrochloride, which work together to inhibit Malassezia furfur while maintaining the scalp's natural barrier function. The formulation is formulated with a balanced ratio of these ingredients, along with preservatives, essence, and pH adjuster, and is suitable for daily use.
9. Scalp Formula Comprising Plant Extracts, Ceramides, Phytosterol Esters, and Specific Emulsifiers
BEIJING DONGFANG MIAOMIAO BIOTECHNOLOGY CO LTD, 2021
Scalp health improvement formula containing plant extracts, ceramides, phytosterol esters, sunflower oil, caprylic/capric triglycerides, phospholipid, beeswax, rosemary extract, and ethanol. The formula is designed to enhance scalp health by regulating microbial balance, repairing barrier function, and reducing oil accumulation. The preparation method involves extracting plant materials at specific temperatures to avoid deterioration. The formula contains ingredients like cationic conditioners, alkyl sugar shakes, polyether emulsifiers, and disodium EDTA to optimize scalp benefits.
10. Scalp and Hair Care Composition with Sulfur, Piroctone Olamine, Caprylylglycine, and Zinc Gluconate
GUANGZHOU BEAVER COSMETIC CO LTD, 2021
Anti-dandruff and oil-controlling composition for scalp and hair care products. The composition contains sulfur, piroctone olamine salt, caprylylglycine, zinc gluconate, moisturizers, anti-allergic agents, preservatives, and solvents. The sulfur and piroctone olamine salt control dandruff by regulating the Malassezia fungus and sebum balance. Caprylylglycine and zinc gluconate reduce oiliness by inhibiting sebum production. The composition also contains moisturizers to prevent dryness. The anti-allergic agents and preservatives prevent irritation and spoilage. The solvents dissolve the ingredients.
11. Scalp Care Composition with Zinc Pyrithione, Witch Hazel Extract, Polyethylene Glycol-14M, Dipotassium Glycyrrhizinate, and Lactobacillus Fermentation Product
GUANGZHOU UNIASIA COSMETICS TECHNOLOGY CO LTD, 2021
Scalp care composition with the function of regulating scalp microecological balance, containing zinc pyrithione, North American witch hazel extract, polyethylene glycol-14M, dipotassium glycyrrhizinate, and Lactobacillus fermentation product. The composition helps balance the scalp microbiota to address scalp issues like dandruff by regulating oil production, barrier function, and microbial populations.
12. Shampoo Composition with PCA Sodium, Nicotinamide, Potassium Undecylenyl Hydrolyzed Wheat Protein, and Cinnamic Aldehyde Sulfate Sodium
GUANGZHOU KENENG COSMETIC RESEARCH CO LTD, 2020
A shampoo composition that addresses dandruff through a novel combination of ingredients. The composition comprises PCA sodium, nicotinamide, potassium undecylenyl hydrolyzed wheat protein, and Cinnamic Aldehyde Sulfate Sodium, which work synergistically to maintain the scalp's natural barrier function while preventing Malassezia overgrowth. The formulation is enhanced with a preservative system that prevents irritation and maintains the scalp's microenvironment.
13. Scalp Care Composition with Synergistic Blend of Propylene Glycol Laurate, Plant Sphingosine, and Botanical Extracts
GUANGZHOU DEGU PERSONAL-CARE SUPPLY CO LTD, 2020
A scalp care composition that enhances the diversity of scalp microorganisms through a synergistic blend of natural ingredients. The composition combines propylene glycol laurate, plant sphingosine, Sophora flavescens extract, tea saponin, ginseng saponin, lactic acid, peppermint oil, and menthol to create a balanced formula that promotes a healthy scalp ecosystem. The composition addresses the imbalance of microbial populations in the scalp, particularly Propionibacterium acnes and Staphylococcus epidermidis, while maintaining a delicate balance of the skin's natural flora.
14. Non-Foaming Surfactant System with Polyglyceryl Laurate and Sodium Cocoyl Methyl Taurate for Selective Sebum Component Removal
YUNNAN BAIYAO GROUP HEALTH PRODUCTS CO LTD, 2020
Selective cleaning composition for scalp hair care that effectively removes high-risk components of sebum while maintaining scalp barrier function. The composition combines polyglyceryl laurate and sodium cocoyl methyl taurate, which form a mild, non-foaming surfactant system. This surfactant system gently cleans sebum components without compromising the protective barrier function of the scalp, while reducing inflammation caused by unsaturated fatty acids. The composition demonstrates enhanced cleaning efficiency for sebum compared to traditional surfactants, with a lower cleaning rate index for oleic acid.
15. Silicone-Free Shampoo Composition with Zinc Gluconate, Turmeric Extract, Ceramide, Amino Acids, and Natural Surfactants
GUANGZHOU BOYA COSMETICS CO LTD, 2020
An oil control and anti-dandruff shampoo composition that provides effective scalp care without silicone and with improved conditioning properties compared to traditional silicone-free shampoos. The composition contains zinc gluconate, turmeric extract, ceramide, amino acids, and natural surfactants to control oil, prevent dandruff, and improve scalp health. It aims to address issues like excessive sebum production, dandruff, scalp irritation, and poor combing performance of some silicone-free shampoos.
16. Shampoo Composition with Rice Water, Zinc Compounds, and Hydrolyzed Rice Protein
XINFANG BIOTECHNOLOGY CO LTD, 2020
Shampoo formulation for controlling dandruff and itchiness through a unique combination of natural ingredients. The formulation incorporates rice water, which is rich in alkaloids and other beneficial compounds, along with key active ingredients like zinc chloride, zinc pyrithione, and keratin. The formulation also contains hydrolyzed rice protein, caprylyl glycine, and magnesium chloride, which work synergistically to address scalp conditions while providing moisturizing and strengthening benefits. The shampoo's unique composition enables effective dandruff control, itch relief, and improved hair quality through its balanced blend of natural and synthetic ingredients.
17. Scalp Microecology Regulating Composition with Lactobacillus/Soy Milk Fermentation Filtrate, Chicory Extract, and Agave Leaf Extract
TIANJIN NIQU BIOTECHNOLOGY CO LTD, 2020
Composition for regulating scalp microecology to improve dandruff, oil control, and itchiness. The composition contains lactobacillus/soy milk fermentation filtrate, chicory extract, and agave leaf extract. It also has surfactants, thickeners, pH regulators, conditioning agents, chelating agents, and anti-dandruff agents.
18. Shampoo Composition with Zinc Pyrrolidone Carboxylate, Piroctone Ethanolamine Salt, and Climbazole
GUANGZHOU BAIYUN LIANJIA FINE CHEMICAL FACTORY, 2020
A shampoo composition that combines effective dandruff treatment with moisturizing properties to address scalp issues. The composition incorporates a combination of surfactants and active ingredients, including zinc pyrrolidone carboxylate, piroctone ethanolamine salt, and Climbazole, to provide both anti-dandruff and moisturizing benefits. The surfactants help control oil production, while the active ingredients address dandruff and scalp irritation. The formulation maintains moisture levels, making it suitable for sensitive scalps.
19. Shampoo Composition with Zinc Pyridinethione, Piroctone Ethanolamine, and Botanical Extracts for Microbial Flora Balance
FOSHAN LYUYOU NETWORK TECH CO LTD, 2019
Anti-dandruff shampoo that improves scalp health by balancing the microbial flora. The shampoo contains zinc pyridinethione and piroctone ethanolamine salt for bactericide action, but also celery seed extract, silk hydrolysate, and bilberry berry extract to inhibit bacteria and improve scalp environment. This synergistic combination sterilizes and inhibits bacteria to improve scalp microbiome, increase resistance, and prevent dandruff recurrence.
20. Scalp Care Composition with Piroctone Ethanolamine Salt, Hydrolyzed Corn Starch, Ginkgo Biloba Extract, and Dipotassium Glycyrrhizinate
GUANGZHOU UNIASIA COSMETICS TECHNOLOGY CO LTD, 2019
Scalp care composition for treating dandruff and itching that contains piroctone ethanolamine salt, hydrolyzed corn starch, ginkgo biloba extract, and dipotassium glycyrrhizinate. These components cooperate to effectively remove scalp scales, improve moisture, and reduce itching. The composition can be used in shampoos to provide less irritating, more effective anti-dandruff and anti-itch treatment compared to using individual components.
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