Malassezia Growth Inhibition Using Medium-Chain Fatty Acid Derivatives
Malassezia species colonize human skin at densities of 104-106 cells/cm2, with particularly high concentrations in sebum-rich areas. The lipophilic nature of these fungi enables them to metabolize medium-chain fatty acids (C8-C14), producing byproducts that can trigger inflammatory cascades and disrupt skin barrier function when fungal populations exceed normal thresholds.
The challenge lies in selectively controlling Malassezia proliferation while preserving beneficial microflora and maintaining the skin's natural lipid balance.
This page brings together solutions from recent research—including plant extract formulations containing phenolic acids and flavonoids, specialized surfactant systems with caprylic derivatives, scalp microecology stabilizers, and azelaic acid/zinc salt combinations. These and other approaches offer practical strategies for formulating personal care products that effectively manage Malassezia-associated conditions without compromising scalp health.
1. Scalp and Hair Care Composition with Sulfur, Piroctone Olamine, Caprylylglycine, and Zinc Gluconate
GUANGZHOU BEAVER COSMETIC CO LTD, 2021
Anti-dandruff and oil-controlling composition for scalp and hair care products. The composition contains sulfur, piroctone olamine salt, caprylylglycine, zinc gluconate, moisturizers, anti-allergic agents, preservatives, and solvents. The sulfur and piroctone olamine salt control dandruff by regulating the Malassezia fungus and sebum balance. Caprylylglycine and zinc gluconate reduce oiliness by inhibiting sebum production. The composition also contains moisturizers to prevent dryness. The anti-allergic agents and preservatives prevent irritation and spoilage. The solvents dissolve the ingredients.
2. Shampoo Composition with PCA Sodium, Nicotinamide, Potassium Undecylenyl Hydrolyzed Wheat Protein, and Cinnamic Aldehyde Sulfate Sodium
GUANGZHOU KENENG COSMETIC RESEARCH CO LTD, 2020
A shampoo composition that addresses dandruff through a novel combination of ingredients. The composition comprises PCA sodium, nicotinamide, potassium undecylenyl hydrolyzed wheat protein, and Cinnamic Aldehyde Sulfate Sodium, which work synergistically to maintain the scalp's natural barrier function while preventing Malassezia overgrowth. The formulation is enhanced with a preservative system that prevents irritation and maintains the scalp's microenvironment.
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