39 patents in this list

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The loss of skin elasticity represents a significant challenge in dermatological science, with elastin fiber degradation occurring at approximately 1-2% per year after age 25. Clinical studies show that by age 60, skin can lose up to 50% of its elastic properties, leading to decreased mechanical resistance and increased susceptibility to environmental stress.

The fundamental challenge lies in developing compounds that can effectively stimulate elastin production in adult fibroblasts while ensuring these newly synthesized proteins properly assemble into functional elastic fibers.

This page brings together solutions from recent research—including demethoxypodopterin-based elastin stimulation, tetrapeptide derivatives for fibroblast activation, modified disaccharide polysulfates, and targeted molecular transport systems. These and other approaches focus on practical formulations that can be incorporated into topical treatments while maintaining stability and bioavailability.

1. Demethoxypodopterin-Induced Elastin Production in Fibroblasts

SHANGHAI JAHWA UNITED CO LTD, 2024

Using demethoxypodopterin, a natural compound found in plants, to promote elastin production in skin. Elastin is a key protein for skin elasticity and reducing wrinkles. By discovering that demethoxypodopterin increases elastin generation by fibroblasts, the invention provides a way to improve skin firmness and resist sagging using this compound. It suggests using demethoxypodopterin as an ingredient in skin care products, medicines, and health foods to help maintain skin elasticity and combat aging.

CN117982358A-patent-drawing

2. Skin Care Composition with Teprenone, Collagen, Hydroxypropyl Tetrahydropyrantriol, and Diamond Micropowder

GUANGZHOU YANZHI COSMETICS CO LTD, Guangzhou Yanzhi Cosmetics Co., Ltd., 2024

Multi-effect anti-aging skin care composition and preparation method using a specific combination of ingredients. The composition includes teprenone, collagen, hydroxypropyl tetrahydropyrantriol, and diamond micropowder. This blend of ingredients provides multiple anti-aging benefits like improving skin elasticity, reducing water loss, and boosting collagen production. The composition can be used in skin care products like creams and lotions.

3. Collagen and Elastin Biosynthesis System with Specific Amino Acid and Oligopeptide Transport and Administration

Elastic Lab Co., Ltd., ELASTIC LAB INC, 2024

Enhancing biosynthesis of collagen and elastin, which are components of dermal tissue, and are enhanced when certain amino acids and oligopeptides are properly transported and administered topically or orally. The biosynthesis includes glycine, L-proline and divalent metal ions, each having a content ratio of 1:0.9 to 1:1.1, and a variety of oligopeptides in a single component for the biosynthesis of elastin and collagen.

CN113260367B-patent-drawing

4. Anti-Aging Composition with Modified Disaccharide Polysulfates, Elastin, Collagen, and Chondroitin Sulfate

MAGELINE BIOTECHNOLOGY CO LTD, 2023

Anti-aging skin care product containing modified disaccharide polysulfates, elastin, collagen, and chondroitin sulfate to improve skin elasticity and firmness. The disaccharide polysulfate is obtained by sulfating a disaccharide. The anti-aging composition contains modified disaccharide polysulfate at 0.01-0.5% of the total product mass, collagen at 0.01-5%, and elastin at 0.01-5%. The composition promotes skin firmness, reduces wrinkles, and repairs the skin barrier.

CN117297998A-patent-drawing

5. Vermilion Chinensis Extract with Anti-Hyaluronidase Activity and Antioxidant Properties for Modulating Collagen and Elastin Production

GREENYN BIOTECHNOLOGY CO LTD, 2023

Vermilion chinensis extract improves skin condition through enhanced collagen and elastin production, particularly in the skin's dermal layer. The extract, with its anti-hyaluronidase activity, anti-inflammatory properties, and antioxidant capabilities, promotes skin elasticity and reduces wrinkle formation. By inhibiting collagen degradation and modulating inflammatory responses, the extract effectively increases skin moisture content, suppresses skin sensitivity, and improves skin tone.

6. Steroid Antibiotic with Modulated MMP-1 Expression and Collagen and Elastin Expression Enhancement

COSMAX INC, 2023

Steroid antibiotic that suppresses the expression of MMP-1 increased by ultraviolet rays and increases the expression of collagen and elastin. The antibiotic inhibits the expression of MMP-1 increased by ultraviolet rays and increases the expression of collagen and elastin.

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7. Dermal Agent with 1-(2-Hydroxyethyl)-2-Imidazolidinone Derivatives for LTBP2 and Fibrillin 1 Expression Enhancement

SHISEIDO CO LTD, 2023

A dermal elasticity improving agent that promotes the production of LTBP2 and/or fibrillin 1, thereby increasing and/or stabilizing the dermal papillary layer fibers. The agent contains 1-(2-hydroxyethyl)-2-imidazolidinone or its derivatives as an active ingredient. These compounds enhance the expression of LTBP2 and/or fibrillin 1 in fibroblasts, leading to increased dermal papillary fiber growth and stabilization. This agent can be used in non-therapeutic cosmetic formulations to improve skin elasticity and wrinkle appearance.

CN116615196A-patent-drawing

8. Skin Care Composition Incorporating Vitexin with Variable Concentration for Modulating Collagen and Elastin Synthesis

SHANGHAI JAHWA UNITED CO LTD, 2023

Using vitexin, a natural compound found in plants like chamomile and hops, to promote collagen and elastin production in the skin. Vitexin can be added to skin care products to help improve skin sagging, wrinkles, and loss of elasticity. The effect of vitexin on collagen and elastin production by human fibroblast cells was discovered. The concentration range for vitexin in skin products is 0.001-20% by weight.

9. Tetrapeptide Derivatives with NA-Pro-Lys-Glu-Lys-OH Sequence for Fibroblast Activity Enhancement and Collagen Stimulation

SHENZHEN WEIQI TECH CO LTD, 2023

Tetrapeptide derivatives for skin repair and firming that enhance fibroblast activity, promote cell proliferation, and improve skin elasticity. The derivatives, with the sequence NA-Pro-Lys-Glu-Lys-OH, are designed to stimulate collagen production and skin firmness while maintaining non-irritating safety. They can be incorporated into topical formulations for skin rejuvenation, addressing the underlying causes of aging and environmental damage.

10. Anti-Aging Composition with Natural Peptides, Alpinia Japonicus Extract, and Growth Factors in Water-Based Delivery System

GUANGZHOU YOURAN BIOLOGICAL TECH CO LTD, 2023

A novel anti-aging firming composition that combines natural peptides, plant extracts, and a proprietary blend of peptides with specific skin cell functions to improve skin elasticity and firmness. The composition contains a unique combination of peptides, including Alpinia japonicus extract, muscle factor, and specific growth factors, which work synergistically to enhance collagen production, regulate elastin levels, and suppress excessive fibroblast activity. The composition is formulated in a water-based delivery system and is suitable for sensitive skin types.

CN115919723A-patent-drawing

11. Pharmaceutical Compositions with Vitamin D and Tannic Acid for Modulating Elastin Synthesis

ELASTOGENESIS LLC, 2023

Pharmaceutical compositions that enhance elastin production in damaged tissues, particularly in skin and vascular tissues, through the combination of vitamin D and tannic acid. The compositions contain a vitamin D compound and a tannic acid compound, with concentrations ranging from 0.1 nM to 100 nM. This dual-action approach promotes elastin synthesis while counteracting the inhibitory effects of vitamin D and other elastin-degrading agents. The compositions can be administered orally or topically to improve tissue health and prevent age-related tissue damage.

12. Composition of Fermented Extract from Mixed Green Tea, Ginger, and Cypress Using Lactic Acid Bacteria

The Skins, Enbi Bio Company, DUSKINS, 2023

A composition containing a fermented extract of a mixed natural product blend for improving skin condition, reducing inflammation, and enhancing elasticity. The composition comprises a complex fermented extract obtained by fermenting a mixed extract of green tea, ginger, and cypress using lactic acid bacteria. The fermented extract has significantly higher anti-inflammatory and elastase inhibitory activity compared to the non-fermented extracts. This makes it useful for anti-inflammatory, skin elasticity enhancement, and wrinkle improvement applications.

13. Composition Comprising Cordycepin, Andrographolide, and Quercetin with Synergistic Effects on Basement Membrane Integrity

LG HOUSEHOLD & HEALTH CARE LTD, 2022

Composition for improving skin elasticity and wrinkles through enhanced basement membrane integrity. The composition incorporates a synergistic combination of cordycepin, andrographolide, and quercetin, which together strengthen the dermal layer and improve skin elasticity. This combination provides superior anti-aging effects compared to individual components alone, particularly when used together.

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14. Cosmetic Composition with Silver Fir Essential Oil and Ester-Based Actives Containing Limonene, Alpha-Pinene, Camphene, and Bornyl Acetate in Defined Molar Ratio

UNIVERSITE COTE DAZUR, 2022

A cosmetic composition that prevents skin aging by inhibiting elastase degradation of skin elastic fibers. The composition utilizes essential oil from silver fir branches, which contains limonene as its main component, with secondary components of alpha-pinene, camphene, and bornyl acetate in a specific molar ratio. The oil is combined with other anti-aging actives, including esters of acids and monoalcohols, to create a topical treatment that effectively prevents the breakdown of skin elastic fibers and maintains skin elasticity and suppleness.

15. Plant Extract with Collagen and Elastin Structure Preservation for Skin Density and Elasticity Enhancement

FUNDACION COPEC UNIV CATOLICA, 2022

Antiaging and skin regeneration properties in pharmaceutical and cosmetic applications. The extract improves skin density, improves skin elasticity and firmness, maintains the collagen and elastin structure, avoiding its degradation.

16. Composition of Elastin Peptides and Sophora Japonica Extract with Bioactive Compound Integration

SIRIO PHARMA CO LTD, 2022

A composition containing elastin peptides and Sophora japonica extract that rapidly restores skin elasticity and hydration through enhanced elastin production. The composition combines elastin peptides with Sophora japonica extract, which contains bioactive compounds like rutin and papain, to promote skin tissue regeneration and improve skin elasticity. The combination of these two natural ingredients enables accelerated skin rejuvenation compared to traditional anti-aging treatments.

17. Composition Containing Four-Leaf Clover Extract with Elastin-Promoting Properties

ICHIMARU FALCOS CO LTD, 2022

A composition and method for promoting elastin production in human skin and materials through natural extracts, particularly from the four-leaf clover. The composition contains an extract of four-leaf clover, which is a natural source of elastin-promoting activity. The extract can be used in various cosmetic formulations, including creams, serums, and topical treatments, to enhance skin elasticity and firmness. The composition can also be administered orally to promote elastin production through systemic delivery.

18. Fibroblast-Targeted Composition with Glycine, L-Proline, and Divalent Metal Ions in Specific Ratio

ELASTIC LAB INC, ELASTIC LAB INC, ILASTIC LAB INC, 2022

Composition for promoting elastin and collagen biosynthesis in fibroblasts, comprising glycine, L-proline, and divalent metal ions, with a specific ratio of glycine to L-proline of 1:0.9-1.1. The composition enhances fibroblast expression of genes involved in collagen and elastin biosynthesis, particularly through the synergistic action of glycine, L-proline, and divalent metal ions. This composition can be used to promote tissue repair and prevent skin aging and photoaging by supporting the production of elastin and collagen.

19. Topical Cosmetic Composition with Synergistic Plant Extract Blend for Enhanced Skin Structure

MARY KAY INC, 2022

A topical cosmetic composition that improves skin firmness and elasticity through a synergistic combination of plant extracts. The composition combines Argania spinosa kernel extract, dill extract, Myrciaria dubia fruit extract, Croton lechleri extract, and Morus alba fruit extract to enhance skin texture and structure. The extracts work together to increase elastin, collagen, laminin, and fibronectin production, leading to improved skin firmness, elasticity, and facial contouring. The composition can be formulated into a variety of topical products, including masks, serums, creams, and gels, and is suitable for use on the neck and facial areas.

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20. Composition of Wine Dregs Extract and Yeast Fermentation Products with Botanical Extracts and Glucans for Cosmetic Applications

GUANGDONG MARUBI BIOLOGICAL TECH CO LTD, 2022

A composition and preparation method for anti-aging and wrinkle-reducing cosmetics that combines antioxidant properties with elastin supplementation. The composition comprises a synergistic blend of wine dregs extract, yeast fermentation products, Rehmannia glutinosa extract, kapok extract, glucan, Schizophyllan, and soy isoflavones. The formulation is formulated as a cosmetic product that provides comprehensive anti-aging and wrinkle repair capabilities through its antioxidant activity, elastin replenishment, and cell metabolism regulation.

CN114848541A-patent-drawing

21. Composition Containing Collagen and Elastin Peptides with Botanical Extracts and Adjuvants

22. Skincare Composition with Putia Flower Extract for Elastin and Mitochondrial Stimulation

23. Cosmetic Composition with Rosemary, Grape Fern, Mulberry, and Porphyridium Cruentum Extracts

24. Cosmetic Composition with Syringa Extract and Synergistic Natural Ingredient Blend

25. Peptide Derivatives with Sequence H-Ala-Hyp-Arg-Arg-NH-benzyl for Fibroblast and Keratinocyte Modulation

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