Nanoliposomes for peptide delivery to hair follicles present significant technical challenges in stability, permeation, and bioavailability. Current formulations achieve encapsulation efficiencies between 60-85% for active peptides, but face rapid degradation in scalp environments where pH variations (4.5-5.5) and sebaceous secretions compromise vesicle integrity. Transdermal penetration measurements show that conventional liposomes deliver only 12-18% of encapsulated peptides to the hair follicle bulge region where stem cells reside.

The fundamental challenge lies in engineering nanoliposomal structures that maintain stability in topical formulations while achieving targeted delivery to hair follicle depths without triggering immune responses or premature payload release.

This page brings together solutions from recent research—including hybrid liposome-niosome particles for enhanced follicular penetration, engineered nanovesicles derived from induced pluripotent stem cells for siRNA delivery, lipid bilayer nano-composites incorporating diaminopyridine oxide, and peptide nanocapsules with specialized lipid matrices for stem cell regeneration. These and other approaches demonstrate how advanced formulation techniques are addressing the barriers to effective peptide delivery for hair growth applications.

1. Liposomal Blue Copper Peptide Formulation with Platycladus Orientalis Extract Encapsulation

HANGZHOU PEPTIDE BIOCHEM CO LTD, SHANGHAI NEIJIANHUI BIOLOGICAL TECH CO LTD, SHANGHAI NEIJIANHUI BIOLOGICAL TECHNOLOGY CO LTD, 2024

A liposomal formulation of blue copper peptide for hair growth enhancement. The formulation combines blue copper peptide encapsulated in liposomes with Platycladus orientalis extract, which enhances hair growth by promoting angiogenesis, reducing scalp Propionibacterium acnes and Malassezia, and regulating scalp oil secretion. The liposomes facilitate transdermal delivery of the extract components into the hair follicle, where they stimulate hair growth while inhibiting excessive oil production.

2. Nanoliposome Comprising Diaminopyrimidine Oxide and Plant Extracts with Lecithin and Cholesterol

YANGZHUANGYUAN NETWORK TECHNOLOGY CO LTD, Yangzhuangyuan Network Technology Co., Ltd., 2024

Nanoliposome for hair loss prevention and strengthening that contains a blend of ingredients like diaminopyrimidine oxide, plant extracts, lecithin, emulsifiers, antioxidants, and cholesterol. The liposome has anti-hair loss and hair solidifying properties due to the synergistic effects of the ingredients. The plant extracts like Platycladus orientalis, Radix Dipsaci, Radix Ophiopogonis, Rhodiola rosea, Laminaria japonica, Artemisia capillaris, Goldenseal fruit, and green tea improve scalp health, reduce inflammation, inhibit fungal growth, enhance blood circulation, and nourish hair follicles to prevent hair loss and promote hair growth.

3. Nanovesicles from Human Induced Pluripotent Stem Cells with siRNA Encapsulation Targeting Hair Growth Regulatory Genes

SHANGHAI MILIANG BIOTECHNOLOGY CO LTD, 2024

Engineered nanovesicles derived from human induced pluripotent stem cells (hiPSCs) that promote hair regeneration through targeted delivery of small interfering RNA (siRNA) against specific hair growth regulatory genes. The nanovesicles, encapsulated in uniform vesicles, contain siRNA targeting TGF-β1, Lats1, and SFRP1, which inhibit key pathways involved in hair follicle growth and maintenance. These nanovesicles can be engineered to target specific hair growth stages and are administered via microneedle injection to promote hair growth in conditions like androgenetic alopecia.

4. Nanoscale Delivery System with Liposome-Niosome Hybrid Particles for Black Galangal and Gotu Kola Extracts

NATIONAL SCIENCE AND TECHNOLOGY DEVELOPMENT AGENCY, 2023

A system for delivering black galangal extract and Gotu Kola extract in the form of nanoscale particles that combine the advantages of liposomes and niosomes. The particles are engineered to retain these bioactive compounds while maintaining their structural integrity. The system enables controlled release of these extracts through cell culture systems, providing a stable and sustained delivery of bioactive compounds for various applications, including wound healing, skin care, and hair growth promotion.

TH21519U-patent-drawing

5. Topical Hydrogel Matrix with Nanostructured Lipid Carriers and Zinc Oxide Nanoparticles for Finasteride and Arginine Delivery

PREETI K SURESH, 2023

A topical hydrogel matrix formulation for hair growth and alopecia treatment that combines Finasteride and Arginine with zinc oxide nanoparticles. The formulation delivers the active ingredients through a synergistic combination of nanostructured lipid carriers (NLCs) and zinc oxide nanoparticles, enabling targeted delivery to the scalp and systemic circulation. The NLCs facilitate skin penetration, while the zinc oxide nanoparticles enhance hair follicle penetration and promote hair growth. The formulation provides sustained release of Finasteride and Arginine, significantly reducing systemic side effects compared to conventional oral administration.

IN202321000192A-patent-drawing

6. Growth Hormone Delivery System with Liposome-Encapsulated Formulation in Cream Base

NATIONAL INSTITUTE OF GENETIC ENGINEERING, Biotechnology, BIOTECHNOLOGY, 2022

A growth hormone delivery system for skin care products that enables effective penetration through the skin barrier. The system comprises growth hormone encapsulated in liposomes, which are encapsulated in a cream base. The liposomes are formulated to maintain their stability and structure during cream formulation, while the growth hormone maintains its biological activity. This combination enables rapid and sustained delivery of growth hormone to the skin, addressing its limitations in penetrating the skin barrier. The liposomes protect the growth hormone from degradation and facilitate its absorption through the skin, while the cream base provides a suitable environment for the liposomes to interact with the skin.

7. Nano-Composite with Lipid Bilayer Structure Incorporating Diaminopyridine Oxide and Peptides for Keratin Interaction and Follicular Penetration

WUHAN BEST CARRIER BIOTECHNOLOGY CO LTD, 2021

A nano-composite for preventing hair loss, promoting hair growth, and fixing black hair through synergistic action of hair growth promoters, hair-fixing peptides, and black hair peptides. The nano-composite is a combination of diaminopyridine oxide, pyrrolidinyl diaminopyridine oxide, hair-growth peptides, hair-fixing peptides, and black hair peptides, which form a lipid bilayer structure that penetrates the skin's stratum corneum, interacts with keratin, and promotes active substance penetration into the hair follicle. The nano-composite provides enhanced anti-hair loss, anti-hair growth, and anti-black hair effects compared to conventional treatments, with a low content of active ingredients.

8. Hair Growth Liquid with Pyrrolidinyl Diaminopyridine Oxide and Botanical Extracts for Enhanced Scalp Absorption

SICHUAN PIONEER HUIMEI BIOTECHNOLOGY CO LTD, 2020

Anti-dropping hair growth liquid that prevents hair loss while enhancing scalp nutrition and reducing sensitivity. The formula combines pyrrolidinyl diaminopyridine oxide, biotin, vitamin B3, vitamin B6, ginseng, safflower, ginger, and arborvitae extract to promote blood circulation and hair growth. The liquid is formulated with butanediol to reduce inflammation and improve transdermal absorption. The combination of these ingredients addresses the underlying causes of hair loss, particularly excessive hair follicle miniaturization, while maintaining a gentle and non-irritating formulation.

CN111759782A-patent-drawing

9. Peptide Nanocapsules with Lipid Matrix Encapsulation for Hair Follicle Stem Cell Regeneration

SHANGHAI RUISIDE BIOTECHNOLOGY CO LTD, 2020

Hair follicle stem cell regeneration peptide nanocapsules for promoting hair growth through targeted delivery of active peptides. The nanocapsules contain a peptide complex derived from hair follicle stem cells, encapsulated in a lipid matrix that enables precise penetration through the skin barrier. The peptide complex is purified from human hair follicle stem cells and processed into nano-lipid vesicles using a proprietary method. These nanocapsules deliver the active peptide to the hair follicle, where they stimulate hair growth through self-renewal and differentiation mechanisms.

CN110974769A-patent-drawing

10. Composition with Plant Extracts, Peptides, and Antioxidants for Scalp Health and Hair Follicle Support

SHANGHAI NEW GAOZI COMESTICS CO LTD, 2020

Hair growth prevention and nourishment composition that addresses the root causes of hair loss through synergistic action of natural ingredients. The composition combines a blend of plant extracts, peptides, and antioxidants to restore scalp health and promote hair growth. The formulation targets the underlying imbalances in the scalp environment, including inflammation, oxidative stress, and bacterial imbalances, to prevent hair loss and promote healthy hair follicle development. The composition is formulated into a shampoo that provides both cleansing and nourishment, addressing the specific needs of hair growth and scalp health.

CN110693743A-patent-drawing

11. Topical Hair Growth Composition Comprising Adenosine, Glycyrrhetinic Acid, Apple Polyphenols, Astragaloside, and Alcohol

SHANGHAI TANGMEI BIOLOGICAL TECH CO LTD, 2019

A topical hair growth treatment that utilizes a novel combination of natural compounds to prevent hair loss and promote hair growth. The composition contains adenosine, glycyrrhetinic acid, apple polyphenols, astragaloside, and alcohol, with a synergistic effect that extends hair growth duration beyond traditional treatments like minoxidil and finasteride. The treatment promotes hair follicle maturation and maintains the resting phase, leading to sustained hair growth.

CN110368397A-patent-drawing

12. Composite Polypeptide Nanovesicle Formulation with Encapsulated Hair Growth-Promoting, Anti-Inflammatory, and Anti-Androgenic Peptides

WUHAN BEST CARRIER BIOTECHNOLOGY CO LTD, 2019

A composite polypeptide nanovesicle formulation for hair growth and prevention of hair loss, comprising a synergistic blend of hair growth-promoting peptides, anti-inflammatory peptides, and anti-androgenic peptides encapsulated in a biocompatible nanocarrier. The formulation combines multiple anti-hair loss mechanisms into a single delivery system, achieving enhanced efficacy through controlled release and penetration into the hair follicle. The nanovesicles have been demonstrated to significantly improve hair growth and prevent hair loss through their synergistic anti-hair loss mechanisms.

13. Multi-Phase Emulsification Solution with Specific Component Phases and Active Ingredients for Hair Follicle Treatment

SHIJIAZHUANG JIANLUOTE NETWORK TECHNOLOGY CO LTD, 2019

Hair growth prevention solution for preventing hair loss and promoting hair growth. The solution contains a combination of emulsification components, including a phase A component, phase B component, phase C component, phase D component, phase E component, phase F component, phase G component, and phase H component. The components are formulated with specific ingredients like adenosine, nicotinamide, and biotin, along with emulsifying agents like sodium hydroxide and glycerin. The solution is prepared through a multi-step process involving phase formation, phase blending, and phase stabilization.

CN110192995A-patent-drawing

14. Composition Comprising Cholesterol, Biological Response Modifiers, Vasodilators, Peptides, White Birch Extract, Dextran, Butanediol, and Water

SHANGHAI LONGXI INVESTMENT CO LTD, 2019

A composition for preventing hair loss and promoting hair growth that contains cholesterol, biological response modifiers, vasodilators, biologically active peptides, white birch extract, dextran, butanediol, and water. The composition aims to improve scalp environment, stimulate collagen synthesis, strengthen hair, and prevent keratin loss to prevent hair loss and promote hair growth.

15. Composition with Cholangio-3,5-Diene, Peptides, and White Birch Extract for Hair Follicle Stimulation

SHANGHAI LONGXI INVESTMENT CO LTD, 2019

Hair loss prevention and hair growth composition containing cholangio-3,5-diene, hair growth agents, antiandrogens, biologically active peptides, white birch extract, dextran, butylene glycol, and water. The composition improves hair growth, reduces hair loss, and enhances scalp health. The active ingredients work synergistically to promote hair follicle growth, repair, and anchoring, moisturize the scalp, and inhibit hair loss factors like DHT. The composition can be applied to hair products like oil, conditioner, lotion, shampoo, mask, etc.

CN110123734A-patent-drawing

16. Composition of Plant Extracts with Bioactive Compounds for Hair Treatment

DONGGUAN NATURAL SALUTEM HEALTH TECHNOLOGY CO LTD, 2019

Natural plant extracts for preventing hair loss and promoting hair growth through enhanced blood circulation and anti-hormonal regulation. The formula combines Platycladus orientalis extract, Angelica extract, Panax notoginseng extract, Sophora flavescens extract, Portulaca oleracea extract, Peppermint extract, Huang's extract, resveratrol, and other bioactive compounds. These extracts work synergistically to prevent hair loss by activating blood vessels, regulating hormone activity, and promoting scalp health.

17. Composition of Inosine, Lupin Hydrolyzed Protein, Caffeine, Arginine, Ornithine, Chitosan, and Polygonum Cuspidatum Extract for Hair Follicle Stimulation and Support

MINGCHEN HEALTH CO LTD, 2019

A hair loss treatment that addresses the underlying causes of hair loss through a multi-faceted approach. The treatment combines inosine, lupin hydrolyzed protein, and caffeine to stimulate hair follicle cells in both the anagen and telogen phases, promoting hair growth and strengthening hair follicle cells. The treatment also contains arginine, ornithine, chitosan, and Polygonum cuspidatum extract to address oxidative stress, inflammation, and nutrient deficiencies. This comprehensive approach provides both hair growth and prevention, addressing the root causes of hair loss and promoting healthy hair follicle function.

18. Topical Hair Growth Agent with Potassium Channel Opener and Biologically Active Peptides

SHANGHAI LONGXI INVESTMENT CO LTD, 2019

A topical hair growth agent containing a hair stromal cell activator that combines potassium channel opener activity with biologically active peptides to stimulate hair follicle activity and promote hair growth. The agent balances the potassium channel opener with biologically active peptides to enhance hair growth while minimizing irritation. The formulation can be applied to various hair care products including shampoos, conditioners, and hair growth treatments.

19. Peptide Composition with Nano-Inclusion Encapsulation for Enhanced Transdermal Delivery and Controlled Release

YUTAI BIOLOGICAL DONGGUAN CO LTD, 2019

An active peptide for hair growth that enhances keratin expression through targeted delivery. The peptide composition includes biotin tripeptide-1, myristoyl pentapeptide-17, myristoyl hexapeptide-16, tripeptide-1 copper, and acetyl tetrapeptide-3, with a concentration range of 0.0001-5%. These peptides, when encapsulated in a nano-inclusion system, exhibit superior stability, safety, and transdermal absorption compared to conventional peptides. The peptide formulation enables controlled release of the active compounds, promoting hair growth by stimulating keratin expression and supporting hair follicle health.

CN109568169A-patent-drawing

20. Nutrient Solution with Peptides and Antioxidants for Hair Follicle Fortification and Texture Enhancement

NANJING XINSHENG MEDICAL TECH CO LTD, 2019

A hair growth, fixation, and care nutrient solution that addresses the root causes of hair loss. The solution combines a proprietary blend of nutrients, peptides, and antioxidants to promote hair growth, strengthen hair follicles, and improve hair texture. The formulation is specifically designed to address the underlying causes of hair loss, including androgenetic alopecia and neuropathic hair loss, while also addressing the common issues of dryness and split ends.

21. Hair Growth Composition with Ligustrazine and Liposome Formulation via Supercritical CO2 Method

22. Cosmetic Composition with Pyrrolidinyl Diaminopyrimidine Oxide, Azelamide Myelin, and Seaweed Extract in Equimolar Ratio

23. Sophorolipid Composition with Surfactant Properties for Hair Follicle Cell Growth

24. Concentrated Hair Spray with Chinese Herbal Extracts, Polyphenols, and Caffeine in Stable Saturated Formulation

25. Small Molecule Inhibitors Targeting JAK-STAT Pathway Components for Hair Follicle Modulation

Get Full Report

Access our comprehensive collection of 27 documents related to this technology