Formulations for Vesicular Phospholipid Transepidermal Penetration

Elastic liposomes for skin care that enhance water-soluble penetration through the skin barrier. The liposomes contain a water-soluble active ingredient, such as a whitening agent, which is dispersed within a polyol component and a lecithin component. The lecithin component, particularly hydrogenated lecithin, enhances the liposomes' stability and deformation properties, while the polyol component facilitates water-soluble penetration through the skin barrier. The liposomes can be prepared with specific weight ratios of lecithin to polyol to achieve optimal penetration characteristics.

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Cosmetic formulations using advanced liposomal constructs to enhance topical delivery of lipophilic and non-lipophilic actives. The formulations incorporate liposomes encapsulating the TXA-CTAC complex, which is a zwitterionic compound that forms a complex with TXA. The liposomes are produced using a multi-layered structure with a hydrophilic core and an outer surface, maintaining a positive charge despite the complex's negative charge. This formulation enables effective delivery of lipophilic and non-lipophilic actives through controlled release, improved skin hydration, and enhanced skin firming properties.

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Liposomes that enhance penetration of oil-soluble plant extracts through their improved membrane properties. The liposomes contain unsaturated lecithin as the lipid component, which enables better solubility and stability of the encapsulated plant extract compared to traditional saturated lecithin-based liposomes. The unsaturated lecithin formulation also enhances the liposome's membrane softness and wrapping activity, allowing the liposomes to penetrate the skin's stratum corneum more effectively. The liposomes' stability in water and skin environment is also improved, making them suitable for cosmetic applications.

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Anionic liposomes with repair properties that enhance skin barrier function and moisturization. The liposomes contain ceramide microemulsions and sodium acetylated hyaluronate, which are incorporated into the liposome structure through a combination of emulsification and microemulsification processes. The liposomes exhibit improved stability compared to conventional liposomes, with fine particle size and minimal particle size change, and demonstrate enhanced skin barrier repair capabilities through their incorporation of ceramide and hyaluronate.

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Liposomes with enhanced transdermal delivery capabilities through the incorporation of tetraspanin CD63. The CD63 protein, which regulates lipid organization and membrane structure, is incorporated into the liposome bilayer to improve the stability and efficacy of liposomes in transdermal delivery systems. By maintaining the structural integrity of the liposome membrane, CD63 enables controlled release of therapeutic agents through the skin's stratum corneum, overcoming the limitations of conventional liposomes.

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Liposomes for cosmetics that achieve sustained release, skin nutrition, and enhanced penetration through controlled osmotic pressure management. The liposomes contain a balanced ratio of hydrogenated lecithin, diol compounds, and liquid oil, with stabilizers and pH regulators added to maintain stability under various conditions. This formulation enables precise control of the osmotic pressure environment within the liposomes, allowing them to maintain their integrity and release active ingredients while maintaining skin health.

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Liposome-containing composition for cosmetics containing liposomes with high content of monolayer structure, which improves the ratio of liposomes with monolayer structure and enhances the content rate of inclusions. The composition contains liposomes with a monolamellar structure, stearyl glycyrrhetinate, polyoxyethylene phytosol, cholesterol, and lecithin, and includes liposomes with a monolayer structure.

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Liposomes encapsulating active ingredients for improved skin delivery and stability. The liposomes contain a combination of surfactant, polyol, and co-emulsifier components, with specific ratios optimized for enhanced encapsulation efficiency and controlled release characteristics. The liposomes are prepared through a multi-step process involving emulsification, lipidization, and encapsulation, resulting in nano-sized particles with improved skin penetration and stability compared to conventional liposomes.

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A stable liposome formulation for skin care products that maintains their encapsulated active ingredients. The formulation comprises liposomes containing phospholipids and sterols, with an additional component of polyoxyethylene phytosterols and polyglycerin fatty acid esters. The formulation is prepared by combining the liposomes with the selected components in a specific ratio, typically between 0.01 to 5% by mass of the liposomes, and then forming the liposomes through high-pressure dispersion. The formulation maintains the liposomes' integrity and encapsulates active ingredients while preventing degradation through controlled dispersion and stabilization.

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Liposome complex that can stabilize active ingredients such as vitamin F and ceramide are stabilized in a high content in a liposome structure, and a cosmetic composition for skin improvement. The complex comprises a lipid bilayer comprising a lipid, an encapsulated vitamin F and ceramide are stabilized in a high content in a liposome structure, and a cosmetic composition for skin improvement comprising a number of active ingredients such as vitamin F and ceramide.

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Submicron liposomes for targeted skin delivery of active ingredients. The liposomes contain a unique composition of lecithin, cholesterol, polyglycerol-3 methyl glucose distearate, methyl glucose sesquistearate, polyol, and oily components, with precise mass ratios. The liposomes are prepared through a controlled emulsification process involving heating and homogenization of the components, followed by high-pressure homogenization to create the final vesicles. These liposomes exhibit enhanced skin penetration compared to conventional liposomes due to their optimized composition and structure.

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Long-circulating liposomes that mimic the skin cell membrane structure, providing enhanced moisturizing and protective barrier benefits. The liposomes contain a unique blend of phosphatidylcholine, malto-oligosaccharide glucoside, glycerin, ceramide, sodium hyaluronate, and polysiloxane quaternary ammonium salt-16, which together form a skin-like membrane structure. The formulation is prepared through a specialized process involving precise lipid composition and buffer addition, followed by high-pressure homogenization to produce long-circulating liposomes.

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Retinol liposomes that enhance skin penetration and stability through a novel formulation combining retinol palmitate with lecithin, hydrogenated phosphatidylcholine, and a stabilizer. The formulation incorporates a specific ratio of these components, along with an antioxidant and moisturizing agent, to create stable liposomes that maintain retinol activity over time. The liposomes are prepared through a controlled emulsion process that incorporates lecithin and hydrogenated phosphatidylcholine as film-forming agents, while retinol palmitate and stabilizer enhance stability and skin penetration.

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Easily absorbed skin repair liposomes that enhance topical delivery of ceramide and tocopherol. The liposomes contain a hydrophobic ceramide and tocopherol encapsulated in a lipid bilayer, with additional surfactants like octyldodecanol and sunflower seed oil. The formulation combines ceramide NP with DS-CERAMIDE Y30 and DS-Soya HPC90, with hydrogenated phosphatidylcholine and cholesterol. The liposomes achieve improved stability and particle size reduction through enhanced hydrophobic-hydrophilic interactions between the ceramide and surfactants.

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Cosmetic base material containing lecithin in liposome form, which provides a stable and skin-compatible emulsion for cosmetic preparations. The base material comprises liposomes encapsulating lecithin and oryzanol, with a water-alcohol ratio optimized for stability and skin compatibility. The liposomes maintain their lecithin content while maintaining the aqueous medium, creating a stable emulsion that delivers the lecithin and oryzanol to the skin.

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A method for creating stable liposomes through a novel molecular clustering process that eliminates the need for organic solvents. The process involves dissolving a mixture of phospholipids, surfactants, and other components in carbon dioxide gas at low temperatures, forming a molecularly dispersed state. This state is then stabilized by passing the mixture through a microfluidizer to create multi-layered liposomes. The resulting liposomes retain their stability and encapsulation properties, enabling the encapsulation of active ingredients without the need for traditional organic solvents.

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Cationic liposomes for enhanced skin absorption that combine the benefits of cationic lipids with the skin's natural barrier function. The liposomes contain a cationic lipid that interacts with the skin's negatively charged surface, while incorporating ceramide and cholesterol components that mimic the skin's natural lipid barrier. This multi-component formulation enables effective delivery of active ingredients through the skin's natural barrier while maintaining biocompatibility and stability.

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Liposomal nanoparticles encapsulating fat-soluble anti-aging ingredients through a novel surfactant-aided formulation. The nanoparticles achieve enhanced encapsulation efficiency by incorporating cholesterol, which surrounds the encapsulated ingredients and stabilizes the liposomes. The phospholipid surfactant enhances the liposomes' stability and biocompatibility, while the cholesterol-encapsulated ingredients improve skin penetration and delivery. This formulation enables the delivery of poorly soluble anti-aging compounds through the skin, with enhanced solubility and stability compared to conventional formulations.

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Liposome-based compositions for delivering skin bioactive substances to improve skin health and beauty. The compositions contain liposomes made with a phospholipid and an edge activator to enhance skin penetration of hydrophilic active ingredients. The liposomes provide stable, effective delivery of skin bioactives like antioxidants, anti-aging compounds, and wrinkle fighters compared to conventional topical applications. This improves skin conditions by addressing issues like aging, damage, and wrinkles.

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Nano liposomes encapsulating cosmetic active ingredients for enhanced skin care delivery. The liposomes contain hydrophobic active ingredients in their lipid bilayer membrane and water-soluble ingredients in their inner aqueous cavity. This dual encapsulation enables controlled release of active ingredients while maintaining stability through lipid bilayer protection. The liposomes can be prepared through a simple mixing process, eliminating the need for complex laboratory equipment and multiple processing steps.

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A liposome formulation for skin care products that enhances skin penetration and stability through targeted delivery of active ingredients. The formulation combines a liposome-based delivery system with a novel skin-boosting composition containing a vitamin C derivative, rice fermented liquid extract, and a polysaccharide extract. The liposomes encapsulate the skin-boosting ingredients, while the rice fermented liquid extract enhances skin texture and firmness, and the polysaccharide extract provides moisturizing properties. The vitamin C derivative enhances skin brightness and collagen production, while the rice fermented liquid extract improves skin elasticity. The liposomes deliver these skin-boosting ingredients to the skin surface, enhancing their penetration and efficacy.

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Liposomes for skin cleansing and anti-aging that enhance efficacy through synergistic delivery of active ingredients. The liposomes contain two distinct particle sizes, with one encapsulating skin cleansing agents and the other delivering anti-aging compounds. The multilayer structure of liposome A prevents degradation and maintains stability, while the nano-scale liposome B facilitates penetration through the stratum corneum. This dual-action delivery system enables targeted action at both the surface and deep dermal layers, delivering sustained release and enhanced penetration of skin cleansing and anti-aging ingredients.

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A skin care composition with improved penetration and efficacy of active ingredients like humus extracts through liposome encapsulation. The composition consists of a liposome group and a separate matrix group. The liposome group contains phospholipids, cholesterol, and humus extract. The liposomes are dispersed in the matrix. The liposome weight is 10-15% of the total composition for daily moisturizers and 24-40% for medical products. This allows the liposomes to encapsulate and deliver the humus extracts through the skin. The matrix holds the liposomes and provides other skin benefits.

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Liposomes containing lauric acid for topical dermatological, cosmetic, and veterinary applications, with complementary anti-inflammatory and antioxidant action. The liposomes are prepared through a novel process that maintains their lamellar structure while incorporating lauric acid, which is a single compound with anti-inflammatory properties. The formulation enables effective delivery of lauric acid in liposomes, minimizing lipid content in the galenic formulation while maintaining its antimicrobial activity against Cutibacterium acnes.

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Elastic liposomes for enhanced skin delivery of active ingredients like antioxidants. The liposomes are prepared using natural surfactants like polyglyceryl-2 caprate and polyglyceryl-10 stearate as edge activators instead of conventional synthetic surfactants. This improves liposome stability and enables efficient skin penetration. The elastic liposomes have small size, high entrapment efficiency, and low variability compared to conventional liposomes. Loading antioxidants like taxifolin and its derivative into these liposomes showed enhanced skin permeation. The elastic liposomes can be used as a delivery system for active ingredients to improve skin absorption.

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A method for producing liposomes of poorly soluble sphingolipid that can be used in cosmetic formulations. The method involves combining hydrogenated lysophosphatidylcholine and sophorolipids to form liposomes that can be used to stabilize poorly soluble sphingolipid components. The liposomes can be produced through high-speed emulsification and high-pressure emulsification to achieve stable and transparent formulations. The combination of hydrogenated lysophosphatidylcholine and sophorolipids enables the production of liposomes that can be used as a natural emulsifier for poorly soluble sphingolipid components, eliminating the need for polyols and surfactants.

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Emulsified liposome composition with enhanced skin penetration and moisturizing properties, comprising a lipophilic phospholipid formulation. The composition combines a phospholipid with a specific phosphatidyl ethanol amine to choline ratio, along with additional ingredients like red quinoa extract, anti-allergic plant complex, saccharide isomerate, and glycosyl trehalose. The formulation achieves stable liposome structure after high-temperature sterilization, making it suitable for skin care products.

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Ceramide liposomes with liquid crystal structure that improve skin penetration and utilization of ceramide, a key barrier component in the skin. These liposomes have uniform diameter, high water solubility, and stability, overcoming common issues with ceramide formulations. The liposomes maintain their liquid crystal state even at elevated temperatures, enhancing skin penetration and barrier function. This composition enables effective delivery of ceramide to the skin's stratum corneum, addressing skin barrier function and moisture retention concerns associated with aging.

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Elastic liposomes that enhance skin penetration of camellia oil through improved stratum corneum permeability. The liposomes contain camellia oil, phospholipids, an emulsifier, and a water-soluble solvent. The phospholipid composition includes phosphatidylcholine, phosphatidylethanolamine, and other phospholipids. The emulsifier is a polyoxyethylene sorbitan monolaurate. The water-soluble solvent is added in a controlled dropwise manner. The liposomes have a core-shell structure with an elasticizing agent attached to the shell interface, allowing them to deform and penetrate the stratum corneum. The liposomes are prepared through a modified emulsification process that incorporates the camellia oil and other active ingredients into the liposome core.

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Liposome composition for enhanced transdermal delivery of active ingredients through improved skin penetration. The composition comprises hydrogenated lecithin, phosphatidylcholine, polysorbate 80, and lysolecithin, which form stable liposomes that exhibit enhanced water absorption rates compared to conventional emulsions. These liposomes are engineered to facilitate sustained skin penetration through their unique composition and structure, enabling more effective delivery of active ingredients across the skin barrier.

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Anti-wrinkle liposomes that combine superoxide dismutase, hyaluronic acid, and ceramide to deliver potent anti-aging benefits. The liposomes encapsulate these three components in a lipid bilayer, creating a stable, biocompatible delivery system for these active ingredients. The liposomes achieve superior stability and efficacy compared to traditional formulations, with enhanced skin penetration and sustained release properties. This innovative delivery system enables targeted anti-wrinkle treatment while maintaining natural skin moisture levels.

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Natural liposomes containing ceramide and hyaluronic acid that selectively deliver active ingredients into the skin while maintaining barrier function. The liposomes are prepared through a novel emulsification process that incorporates natural emulsifiers, fatty acids, and preservatives, followed by controlled sonic treatment to form stable vesicles. These liposomes selectively capture and transport active ingredients while maintaining skin barrier integrity, offering a novel delivery system for topical treatments.

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Liposomes for skin care that achieve enhanced penetration and skin familiarity through their unique composition. The liposomes contain a natural lecithin and hydrogenated lecithin blend, which provides improved skin compatibility and stability compared to conventional lecithin-based liposomes. The blend enables enhanced penetration into the skin while maintaining the liposome's morphology, resulting in a skin-identical experience. This formulation enables effective delivery of skin-care ingredients through the skin, addressing the challenges of conventional liposomes.

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