Minoxidil-Botanical Extract Compatibility in Hair Growth Formulations

A minoxidil gel for treating hair loss that avoids the issues of traditional minoxidil preparations. The gel uses a deep eutectic solvent made from minoxidil, a hydrogen bond donor, and a hydrogen bond acceptor. This solvent is then emulsified with water using nanoparticles as stabilizers. The resulting Pickering emulsion is then mixed with a gel matrix to form a stable gel. This deep eutectic solvent-based Pickering emulsion gel provides improved drug delivery and absorption compared to traditional minoxidil preparations that use volatile organic solvents.

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Composition containing minoxidil for hair growth improvement, specifically formulated to prevent crystal precipitation. The composition comprises minoxidil, panthenols, and polyhydric alcohol. The polyhydric alcohol, particularly when combined with panthenols, effectively suppresses crystal formation of minoxidil in liquid or semi-solid formulations, maintaining its therapeutic efficacy.

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A method for preparing a stable and effective minoxidil-based topical solution for hair growth. The preparation involves dissolving minoxidil with a glacial acetic acid aqueous solution, followed by the addition of lecithin and homogenization. The resulting solution is then formulated into a topical product with improved stability, penetration, and bioavailability compared to conventional minoxidil preparations. The formulation achieves a particle size of 72.45-78.37 nm, a particle size distribution (PDI) of 0.24-0.26, and a zeta potential of -51.42-50.68 mV, while maintaining a loading capacity of 92.36-94.62% minoxidil.

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A foaming solution for solubilizing minoxidil base with low alcohol concentration, used as a vehicle for solubilizing minoxidil base, particularly in cold concentrations up to 7%. The solution comprises a combination of natural ingredients including eucalyptus leaf essential oil, polyquaternium 10, glycerin, PEG-14m, lactic acid, PEG-40 castor oil, polysorbate 80, phenoxyethanol, and sodium benzoate. This solution maintains the therapeutic efficacy of minoxidil while minimizing skin irritation typically associated with conventional hydroalcoholic vehicles.

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A composition containing minoxidil (6-(1-piperidinyl)-2,4-pyrimidinediamine-3-oxide) that prevents crystal formation. The composition includes minoxidil, panthenol, and a higher aliphatic compound, with the higher aliphatic compound exhibiting crystal-stabilizing properties. The formulation can be used in hair care products to prevent minoxidil crystal formation and maintain its efficacy.

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A minoxidil-based hair restoration treatment that prevents coloration of the formulation over time. The treatment combines minoxidil with tocopherol and/or its derivatives, propylene glycol, lower alcohol, and acid, in a specific concentration ratio. The formulation is prepared through a stepwise process involving mixing the active ingredients with a solvent, followed by adding water and lower alcohol to achieve the final formulation.

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A composition containing minoxidil and the like to improve stability in liquid or semi-solid formulations. The composition contains minoxidil, panthenol, and pyridoxine, along with a higher aliphatic compound, which can be incorporated into the formulation in any order. The method involves incorporating these components in the formulation in any order, with the higher aliphatic compound being added first. The combination provides enhanced stability against crystal precipitation of minoxidil in liquid or semi-solid formulations.

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Compositions and methods for promoting hair growth, preventing hair loss, and treating baldness using a specific combination of a hair growth stimulant and a carboxylic acid. The compositions can be applied topically to the scalp to accelerate hair growth, increase hair thickness, and reduce hair loss. The hair growth stimulant can be any compound that promotes hair growth, such as caffeine, minoxidil, or finasteride. The carboxylic acid can be any compound with 8-24 carbon atoms, like oleic acid. The ratio of the stimulant to acid is 10:1 to 1:1. Additional active ingredients like antibiotics, antifungals, and anti-inflammatories can be added. The compositions can also contain nonionic lipids, emulsifiers, and admixtures like Kreb cycle intermediates

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A composition containing minoxidil and other pharmaceutical components for hair growth that improves stability through the incorporation of specific higher aliphatic compounds. The composition, preferably in a pharmaceutical preparation, contains minoxidil, panthenol and pyridoxine, and a higher aliphatic compound. The method for stabilizing minoxidil involves incorporating one or more selected from the group; (C) a higher aliphatic compound.

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A water-soluble vehicle for solubilizing minoxidil base that maintains its active concentration while preventing irritation. The vehicle comprises water, lavender hydrolate, essential oils from rosemary, juniper, eucalyptus, and other plant extracts, lactic acid, and sodium benzoate. This formulation enables the effective solubilization of minoxidil base at concentrations up to 7% without compromising its therapeutic efficacy, while avoiding the skin irritation associated with traditional hydroalcoholic vehicles.

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A minoxidil-containing external liquid preparation that suppresses coloration resulting from minoxidil degradation. The preparation contains lactic acid, citric acid, or their salts, and a lower alcohol concentration compared to conventional minoxidil preparations. The formulation prevents the formation of colored compounds that can arise during minoxidil dissolution.

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A topical composition containing minoxidil that prevents coloration when dissolved. The composition comprises lactic acid and/or a salt thereof, in addition to minoxidil, to suppress color development in minoxidil-containing solutions. This composition can be used in minoxidil-based treatments for hair growth, particularly for those containing minoxidil in dissolved form.

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A topical treatment for preventing hair loss and promoting hair growth that combines a 5α-reductase inhibitor with minoxidil. The formulation achieves superior efficacy compared to conventional treatments by utilizing a 5α-reductase inhibitor that is less than a quarter of the standard oral dose, while also containing minoxidil. This combination provides sustained hair growth effects through enhanced blood flow to the hair follicles, with the 5α-reductase inhibitor specifically targeting dihydrotestosterone production. The formulation can be administered topically, with dosages ranging from 0.5 to 5 mg of 5α-reductase inhibitor and 0.5 to 5 g of minoxidil.

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Clear liquid preparation containing minoxidil and eucalyptus oil that maintains crystal-free stability during storage. The preparation combines a polyhydric alcohol like glycerin with a lower alcohol and water mixture, ensuring uniform dissolution of the active ingredient. The solution is then mixed with eucalyptus oil and solid minoxidil, resulting in a clear liquid agent that maintains crystal-free stability during storage.

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Retarding hair loss and facilitating hair growth using compositions containing a hair growth stimulator like minoxidil and a specific ester of a carboxylic acid called Cg-C24 alcohol ester. The compositions can be topical formulations for applying to the skin to reduce hair thinning and promote hair regrowth. The ester compound enhances the effects of the hair growth stimulator.

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