Minoxidil Solubilization in Alcohol-Free Hair Growth Formulations

A topical minoxidil formulation that prevents precipitation without glycol-based solvents. The composition contains minoxidil, dibutylhydroxytoluene, and pantothenyl ethyl ether, with concentrations of 3-10% minoxidil. The dibutylhydroxytoluene and pantothenyl ethyl ether inhibit precipitation, while maintaining therapeutic efficacy. The formulation is pH-balanced and filled in a polyethylene terephthalate container.

Source

Composition for preventing minoxidil precipitation in external hair growth treatments. The composition contains minoxidil, dibutylhydroxytoluene, and pantothenyl ethyl ether, with concentrations between 3-10 w/v%, to suppress precipitation of minoxidil crystals. The composition is formulated in a container made of a resin containing polyethylene terephthalate, with a pH range of 5.0-8.0. The dibutylhydroxytoluene and pantothenyl ethyl ether components effectively prevent precipitation of minoxidil crystals, maintaining the composition's effectiveness in external hair growth treatments.

Source

A topical minoxidil formulation that prevents precipitation upon application, particularly when used in minoxidil-based hair treatments. The composition comprises minoxidil, menthol, phosphoric acid, citric acid, lactic acid, hydrochloric acid, acetic acid, sulfuric acid, nitric acid, tartaric acid, gluconic acid, and maleic acid. The formulation maintains a minimum concentration of 5% minoxidil while preventing precipitation through the synergistic effects of these components.

Source

A topical minoxidil formulation that prevents pantothenyl ethyl ether and panthenol degradation and crystal formation during storage. The composition contains minoxidil, pantothenyl ethyl ether and/or panthenol, and glycerin, with a pH above 6.5. The formulation maintains a consistent pH environment, inhibiting the degradation of these active ingredients and preventing crystal formation, even when stored at low temperatures.

Source

A minoxidil topical solution that maintains stability and prevents oxidation during storage and use. The solution contains an antioxidant and metal ion chelating agent, which are incorporated into the formulation during preparation. This combination prevents the formation of reactive oxygen species and metal ions that can cause discoloration and degradation of the minoxidil. The solution maintains its pH and maintains a stable concentration of these key components throughout its shelf life, ensuring consistent quality and efficacy.

Source

A foamable topical pharmaceutical composition that prevents Minoxidil crystal formation during storage and application. The composition contains a water-miscible organic solvent, an organic acid, at least one co-solvent, at least one amphoteric surfactant, at least one non-ionic surfactant, at least one antioxidant, and water. The surfactant system inhibits crystal formation while maintaining a pleasant tactile sensation. The composition is formulated as a foamable solution, suitable for topical application in an aerosol spray format.

Source

A topical minoxidil solution that prevents coloration and crystal formation over time. The composition contains minoxidil, ethanol as a solvent, dibutylhydroxytoluene as an antioxidant, and tartaric acid as a pH adjuster. The solution maintains a pH of 6.0-6.5 and contains 5 g of minoxidil per 100 mL, with a lower alcohol concentration of 20 g of water and 0.5 g of dibutylhydroxytoluene.

Source

Hair growth agent formulation that suppresses crystallization of active ingredients through controlled pH management. The formulation comprises minoxidil, pantothenyl ethyl ether, glycerin, 1,3-butylene glycol, and lactic acid, with a pH range of 6.0 to 6.5. The lactic acid maintains optimal conditions for maintaining the crystalline structure of pantothenyl ethyl ether while preventing precipitation of minoxidil. This formulation provides stable and consistent performance of the active ingredients, particularly in formulations containing pantothenyl ethyl ether.

Source

A composition containing minoxidil that prevents crystal formation and color degradation during storage. The composition contains minoxidil in a controlled concentration range (4-10% by weight) and maintains crystal stability through a unique formulation that suppresses precipitation and color shift. This composition is particularly suitable for commercial minoxidil products that require long-term stability for efficacy.

Source

A topical formulation of 5% minoxidil for treating male pattern baldness that combines enhanced skin penetration with improved bioequivalence. The formulation incorporates propylene glycol, diethylene glycol monoethyl ether, and sodium hyaluronate to enhance solubility and stability, while maintaining the potent vasodilatory effects of minoxidil. The formulation achieves a consistent concentration of minoxidil (90-110%) through precise formulation control, with microbiological testing confirming sterility and safety.

Source

External composition containing minoxidil for hair growth and scalp health, with improved solubility and stability. The composition comprises minoxidil, dibutylhydroxytoluene, and pantothenyl ethyl ether, with a concentration of 3-10% minoxidil. The dibutylhydroxytoluene and pantothenyl ethyl ether components enhance solubility and prevent precipitation of minoxidil, while maintaining a pH range of 5.0-8.0. The composition is filled in a container made of a resin containing polyethylene terephthalate.

Source

External preparation containing minoxidil that enhances skin penetration and reduces discomfort through synergistic action of lauromacrogol and glycerin. The preparation combines minoxidil with a specific composition of lauromacrogol and glycerin that together achieve superior penetration into the dermis. The glycerin enhances skin permeability, while the lauromacrogol facilitates penetration through its solubilizing properties. The combination provides enhanced penetration and reduced discomfort compared to conventional formulations.

Source

A composition for hair growth containing minoxidil that prevents crystal formation and color degradation. The composition contains minoxidil in a formulation that maintains its solubility and stability when applied to the scalp, preventing precipitation and discoloration. The formulation maintains optimal minoxidil concentrations for hair growth while addressing the common issues of minoxidil crystals and coloration.

Source

A composition for external use containing minoxidil that suppresses crystal precipitation and coloring over time, making it suitable for hair growth applications. The composition contains minoxidil in a concentration between 4-10% by weight, with a propylene glycol concentration of 3-9% by weight. The formulation maintains optimal solubility and stability of minoxidil, preventing crystal formation and discoloration, while maintaining excellent usability.

Source

A composition for external use containing minoxidil that prevents crystal formation and coloring over time. The composition contains minoxidil in a concentration range of 3-10% by weight, with crystal precipitation and coloration suppressed through controlled formulation. The formulation can be applied multiple times a day, with a typical application volume of 0.5-2g, and can be used for hair growth or hair growth. The composition maintains efficacy over extended periods, typically 6-12 months, while maintaining stability and preventing unwanted coloration.

Source

A composition for external use containing minoxidil, which is used as an external preparation for medicine, a quasi-drug, or a cosmetic product. The composition contains minoxidil, in a weight ratio of 1:3 to 1:9, in an external composition containing 3 to 10% by weight of minoxidil. The composition has a pH between 6.5 and 7.5, and is formulated with propylene glycol to prevent crystal formation and coloration. The formulation maintains its usability even when exposed to heat or light.

Source

A composition for topical application containing minoxidil, which provides improved solubility and stability for minoxidil formulations. The composition comprises minoxidil, a potent hair growth agent, in a water-based formulation, with a pH adjusted to 6.6-8. This formulation formulation suppresses crystal formation and color degradation of minoxidil, ensuring consistent efficacy and stability over time.

Source

A topical minoxidil formulation that maintains solubility and suppresses crystal formation through the controlled blending of tartrate acid and/or its salt with water. The formulation achieves optimal minoxidil solubility while preventing crystal precipitation, making it suitable for topical treatments.

Source

Cream formulation for minoxidil with improved stability and usability. The formulation contains a combination of isostearic acid, carboxyvinyl polymer, polyoxyethylene sorbitan monooleate, and purified water. The isostearic acid enhances stability, while the carboxyvinyl polymer improves solubility. The polyoxyethylene sorbitan monooleate acts as a stabilizer, and the purified water maintains the formulation's stability. The formulation is hypoallergenic and does not contain alcohol, making it suitable for sensitive skin.

Source

Clear liquid preparation containing minoxidil and eucalyptus oil that maintains crystal-free stability during storage. The preparation combines a polyhydric alcohol like glycerin with a lower alcohol and water mixture, ensuring uniform dissolution of the active ingredient. The solution is then mixed with eucalyptus oil and solid minoxidil, resulting in a clear liquid agent that maintains crystal-free stability during storage.

Source