Formulations for Alopecia Prevention
24 patents in this list
Updated:
Hair loss treatments face significant biological and delivery challenges. Current topical formulations struggle to penetrate the stratum corneum and reach the hair follicle bulge, where stem cells reside at depths of 1-2 mm. Even when active ingredients reach their target, maintaining therapeutic concentrations remains difficult due to sebum barriers and rapid clearance from the follicular environment.
The core challenge lies in developing delivery systems that can both penetrate to the correct tissue depth and sustain therapeutic levels of active ingredients without triggering local inflammation or systemic absorption.
This page brings together solutions from recent research—including nanoparticle-based delivery systems, biosulfur suspensions with controlled particle sizing, and novel prostaglandin/cyclosporine combinations with penetration enhancers. These and other approaches focus on improving both the targeting and sustained release of hair growth agents while maintaining safety and stability in final formulations.
1. Composition Comprising Aqueous Suspension of Biosulfur with Micron-Sized Particles for Hair Follicle Cell Proliferation
ECO BIO HOLDINGS CO LTD, 2024
Composition for preventing hair loss and promoting hair growth containing biosulfur as an active ingredient. The composition prevents hair loss and promotes hair growth by enhancing proliferation of hair follicle cells and hair growth. The biosulfur used in the composition is an aqueous suspension containing elemental sulfur produced through a biological sulfur conversion process. The biosulfur has particle size of 10 microns or less and is stable in suspension. It can be used in hair and scalp products like shampoos, tonics, gels, etc.
2. Nanoparticles with Enhanced Penetration and Sustained Release for Hair Follicle Delivery
PROTRANSIT NANOTHERAPY LLC, 2023
Nanoparticles for topical delivery of hair growth agents and repigmentation agents to improve hair regrowth and reduce graying. The nanoparticles stabilize and deliver the compounds through the skin and into hair follicles. They allow sustained release of the agents and penetration past the sebum plug. Administering the nanoparticles topically concentrates them in hair follicles. This enables targeted delivery and improved efficacy compared to traditional topical hair treatments.
3. Prostaglandin Analogue and Cyclosporine Compositions with Penetration Enhancers for Hair Follicle Stimulation
ANEIRA PHARMA INC, 2023
Compositions and methods for preventing hair loss and promoting hair growth using prostaglandin analogues like latanoprost, travoprost, bimatoprost, and cycloprost, in combination with cyclosporine. The compositions applied to the scalp, eyebrows, eyelashes, and facial hair can increase hair length, thickness, darkness, and melanin content. They convert downy hair to terminal hair, stimulate hair follicle growth, and prevent hair loss during chemotherapy. The prostaglandin analogues and cyclosporine can be used as monotherapies or in combination with minoxidil. The compositions can also contain penetration enhancers like diethylene glycol monoethyl ether and oleyl alcohol.
4. Compositions Containing Nicotinic Acid Adenine Dinucleotide Phosphate with Amino Acids and Growth Factors
Mi Gyoung Yang, 2022
Pharmaceutical and cosmetic compositions for preventing hair loss, promoting hair growth, and improving hair conditions. The compositions contain a specific compound (nicotinic acid adenine dinucleotide phosphate, NAADP) along with other ingredients like amino acids, growth factors, fatty acids, vitamins, etc. The compositions promote cell proliferation, prolong cell life, increase hair root production, density, thickness, and length.
5. Composition Containing Dermal Papilla Cell Proliferation Activator with General Formula (I)
RNS CO LTD, 2022
A composition for preventing hair loss and promoting hair growth. The composition contains a compound that activates the proliferation of dermal papilla cells, which promote hair growth. The compound has the general formula (I) or a salt thereof. It can be used in cosmetic products like lotions, creams, and packs for external application to the skin.
6. Cosmetic Composition with Andrographis Paniculata, Bilberry, and Water Lily Extracts in Specific Ratios
GENPEAU, Genpure, 2022
Cosmetic composition for preventing hair loss and promoting hair growth that contains extracts from three natural ingredients: Andrographis paniculata (Cheonsimryeon), bilberry (Vaccinium myrtillus), and water lily (Nymphaea tetragona). The extracts are used in specific weight ratios to achieve synergistic effects. The composition can contain additional active ingredients like asiaticoside and saw palmetto extract to further enhance hair growth and prevent hair loss.
7. Composition Comprising Spirulina Extract with Phycocyanin and Gamma-Linolenic Acid for Hair Treatment
MODACELL CO LTD, 2022
A composition for preventing or treating hair loss using spirulina extract. The composition contains a spirulina extract, which can alleviate or prevent hair loss, promote hair growth, and improve hair quality. The spirulina extract can be water or alcohol-extracted spirulina. It may also contain a herbal extract. The composition can be used as a pharmaceutical, food, cosmetic, or topical preparation for hair loss treatment. The spirulina extract contains compounds like phycocyanin and gamma-linolenic acid that have anti-inflammatory, antioxidant, and hair growth-promoting properties.
8. Compositions of Prostaglandin Analogues and Cyclosporine for Modulating Hair Follicle Anagen Phase and T Cell Infiltration
ANEIRA PHARMA INC, 2022
Preventing hair loss and stimulating hair growth using prostaglandin analogues like travoprost and bimatoprost in combination with cyclosporine. The compositions can be applied to the scalp or other areas of the body to prevent hair loss in patients undergoing chemotherapy or stimulate hair growth in patients with hair loss disorders like alopecia areata. The prostaglandin analogues promote longer anagen phases of hair growth. Cyclosporine inhibits T cell infiltration into hair follicles. The combination of prostaglandin analogues and cyclosporine allows hair to remain in the anagen phase longer and reduces hair loss during chemotherapy or in hair loss disorders. It also stimulates hair growth and converts vellus hairs to terminal hairs.
9. Composition of Prostaglandin Analogues and Cyclosporine for Hair Growth Stimulation
ANEIRA PHARMA INC, 2021
Using prostaglandin analogues and cyclosporine to treat hair loss and promote hair growth. The composition contains a low concentration of prostaglandin analogues like latanoprost, bimatoprost, or travoprost, and cyclosporine. Applying this combination to the scalp prevents hair loss, increases the anagen phase duration, and converts vellus hairs to terminal hairs. It also enhances hair length, thickness, pigmentation, and reduces hair fallout.
10. Topical Composition with Oil-Solvent System for Enhanced Transdermal Delivery of Active Agents
CHEMISTRYRX, 2021
Topical treatment for hair loss conditions like alopecia using a composition containing an active agent like minoxidil, finasteride, tacrolimus, etc. dissolved in an oil and an aqueous solvent like water, saline, or PBS. The oil helps improve absorption and penetration of the active agent into the scalp. The composition can be applied topically to treat hair loss conditions by improving absorption of the active agent into the scalp.
11. Composition Incorporating L-Tetrahydropalmatine and Natural Ingredient Mixture with Pharmaceutically Acceptable Salt
애경산업, AE KYUNG INDUSTRIAL CO LTD, 2021
Preventing hair loss and promoting hair growth in a manner that minimizes the risk of side effects when used for a long period of time. The preventive system includes L-tetrahydropalmatine as an active ingredient in a composition, a mixture of natural ingredients, and a pharmaceutically acceptable salt of the composition.
12. Composition with Silk Protein and Plasma Components for Topical Hair Treatment
MEDICOSBIOTECH INC, 2020
Composition for treating hair loss or promoting hair growth containing a silk protein and plasma or a component for hair loss. The composition can be used as a pharmaceutical or cosmetic product to treat alopecia or promote hair growth. The active ingredients are silk protein and plasma components like serum. Applying this composition topically to the scalp for several weeks can induce hair growth and inhibit hair loss. The silk protein is a specific type with a structure of repeated silk peptides containing glycine or serine. The composition can be an ointment, gel, shampoo, or other formulation.
13. Compositions Comprising Hair Growth Stimulant and Carboxylic Acid with Defined Ratio
JOHNSON & JOHNSON CONSUMER INC, 2020
Compositions and methods for promoting hair growth, preventing hair loss, and treating baldness using a specific combination of a hair growth stimulant and a carboxylic acid. The compositions can be applied topically to the scalp to accelerate hair growth, increase hair thickness, and reduce hair loss. The hair growth stimulant can be any compound that promotes hair growth, such as caffeine, minoxidil, or finasteride. The carboxylic acid can be any compound with 8-24 carbon atoms, like oleic acid. The ratio of the stimulant to acid is 10:1 to 1:1. Additional active ingredients like antibiotics, antifungals, and anti-inflammatories can be added. The compositions can also contain nonionic lipids, emulsifiers, and admixtures like Kreb cycle intermediates
14. Injection Composition with Keratin and Water-Soluble Polymers for Hair Follicle Stimulation
KERAMEDIX INC, 2019
Injection composition containing keratin for preventing hair loss or promoting hair growth. The composition can be used to treat hair loss and stimulate hair growth when injected into the body. The keratin can be derived from sources like human dermal papilla cells or produced synthetically. The composition can also contain other ingredients like water-soluble polymers to improve efficacy. The keratin injection composition provides an alternative to existing hair growth agents that have side effects or are only available in oral form.
15. Compositions Containing Humanein Protein with Dermal Papilla Cell Proliferation Properties
JEJU NATIONAL UNIV INDUSTRY ACADEMIC COOPERATION FOUNDATION, 2019
Compositions for preventing hair loss and promoting hair growth containing the protein humanein. Humanein is a naturally occurring protein that promotes proliferation of dermal papilla cells, which are important for hair growth. The compositions can be pharmaceuticals, cosmetics, or health supplements for preventing hair loss or promoting hair growth.
16. Composition Comprising Fat-Decomposing Lactic Acid Bacteria Strains Isolated from Kimchi
COENBIO CO LTD, 2018
Composition for preventing hair loss or promoting hair growth containing strains of lactic acid bacteria isolated from kimchi that have fat-decomposing ability. The strains, such as Leukonostoc wholejappelli, Leukonostoc mecenteroides, and Lactobacillus sakei, can degrade fat. Administering these strains or their cultures can prevent hair loss, promote hair growth, improve sexual function, lower cholesterol, and decompose fat.
17. Compositions with Krebs Cycle and Alpha-Keto Acids, Natural Antioxidants, and Olive Oil-Derived Fatty Acid Mixtures
MCNEIL-PPC INC, 2015
Reducing hair loss and facilitating hair growth using compositions containing acids, antioxidants, and specific fatty acid mixtures. The compositions can be applied topically to stimulate hair growth and prevent hair loss in mammals. The acids are from the Krebs cycle or alpha-keto acids, the antioxidants are natural compounds, and the fatty acid mixture is derived from sources like olive oil. The compositions can accelerate the onset of hair growth and increase terminal hair coverage on the skin.
18. Composition Containing Indian Strawberry Extract with 5α-Reductase Inhibition Properties
KO IN-SUN, 2011
A composition for preventing hair loss and promoting hair regrowth using an extract of Indian strawberry (Duchesnea chrysantha). The composition may contain the Indian strawberry extract alone or in combination with extracts from red ginseng or soapberry leaves. The Indian strawberry extract has been found to inhibit an enzyme involved in hair loss, 5α-reductase, as well as promote hair regrowth. The composition can be formulated as a hair tonic, shampoo, topical ointment, or food supplement.
19. Composition of Alpha-Keto Acid, Antioxidant, and Fatty Acid Mixture for Hair Growth Stimulation
MCNEIL-PPC INC, 2011
Reducing hair loss and facilitating hair growth using compositions containing specific acids, antioxidants, and fatty acids. The compositions contain an admixture of an alpha-keto acid, an antioxidant, and a fatty acid mixture. Applying these compositions to the skin can accelerate the onset of hair growth and increase the rate of terminal hair appearance. The acids, antioxidants, and fatty acids work synergistically to promote hair growth.
20. Hair Growth Composition with Anti-Androgenetic Agents and Blood-Sugar Modulating Agents
BIRNBAUM JACOB, 2007
Hair growth composition containing anti-androgenetic agents to treat hair loss and blood-sugar modulating agents to improve hair growth. The anti-androgenetic agents prevent hair loss by slowing down or stopping hair follicle atrophy and shortening. The blood-sugar modulating agents reduce hair loss side effects like scalp irritation and itchiness. Examples of anti-androgenetic agents are finasteride, minoxidil, and spironolactone. Blood-sugar modulating agents include insulin, sulfonylureas, biguanides, thiazolidinediones, and meglitinides.
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