Probiotic Integration in Skincare Formulations

A composition for regulating skin microecological balance that promotes healthy skin by improving skin microbiome diversity. The composition contains five ingredients: lactobacillus/soybean milk fermentation product filtrate, inulin, alpha-glucan oligosaccharides, red pine leaf extract, and lactobacillus fermentation product. The ingredients synergistically promote probiotic growth, inhibit harmful bacteria, eliminate biofilms, and reduce quorum sensing to achieve overall skin microbiome balance. The composition is useful in skin care products to enhance skin barrier, control oil, relieve irritation, and repair skin.

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Composition for improving skin elasticity, skin regeneration, and pore shrinkage through the synergistic effects of three strains of lactic acid bacteria (Lactobacillus subtilis TIMMAY, Lactobacillus rhamnosus PINKBLAC, and Leuconostoc mesenteroid ELASTIC) that exhibit enhanced skin conditions. The composition combines these strains in a complex extract to deliver a potent combination of skin elasticity enhancement, wound regeneration, and pore contraction properties.

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Lactobacillus composition for skin care products that inhibits Staphylococcus aureus adhesion and prevents skin infections. The composition contains specific strains of Lactobacillus, particularly Lactobacillus reuteri and Lactobacillus salivarius, which exhibit enhanced adhesion inhibition capabilities compared to other strains. These strains can prevent S. aureus colonization and reduce its virulence factors, including coagulase, PVL, and exfoliative toxins, thereby protecting the skin barrier and preventing skin conditions like atopic dermatitis.

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Lactobacillus plantarum TWK10 improves skin health through its anti-aging properties. The probiotic strain, which is a new taxonomy designation for Lactobacillus plantarum TWK10, has been found to prevent skin aging by reducing oxidative stress and inflammation. It achieves this through its ability to regulate skin oxidative stress, inflammatory response, and signaling pathways, particularly by inhibiting key enzymes involved in collagen degradation and cell membrane damage. The probiotic can be used in food and cosmetic formulations to prevent and treat skin aging, while also having potential applications in preventing and treating skin diseases like eczema and psoriasis.

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Combining extracts of the plant Polygonum aviculare with synbiotics (probiotics and prebiotics) in specific ratios for dermatological and cosmetic applications. The compositions provide improved skin health benefits compared to using Polygonum extracts or synbiotics alone. The ratios of Polygonum extract to synbiotics range from 10,000:1 to 1:10,000. The compositions can be formulated into creams, gels, lotions, sprays, patches, etc. for skin conditions like eczema, acne, atopy, inflammation, aging, etc. The Polygonum extract and synbiotics synergy provides benefits beyond what each component alone could achieve.

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A topical skin composition for maintaining healthy skin microbiota through direct application of beneficial bacteria. The composition comprises live Lactobacillus strains, specifically Lactobacillus plantarum with at least 97% sequence similarity in its 16S rRNA gene to 5F, which is particularly effective in restoring and maintaining a healthy skin microbiota. The composition is particularly suited for treating skin conditions associated with microbial imbalances, such as acne, athlete's foot, and fungal infections.

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A probiotic postbiotic composition that enhances skin barrier function and reduces allergic reactions through synergistic action of probiotic metabolites. The composition combines inactivated probiotic cells with their metabolites, which are rich in bioactive compounds like organic acids and short-chain fatty acids. This formulation enhances barrier repair, reduces inflammation, and promotes immune tolerance, making it particularly effective in treating skin allergies.

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Cosmetic composition containing a culture of the skin-derived lactic acid bacterium Lactobacillus plantarum HDB (Lactobacillus plantarum HDB, KCCM13182P) strain. The composition enhances skin moisture density and reduces transepidermal water loss by selectively regulating the moisture-friendly skin microbiome. The culture increases expression of proteins responsible for skin barrier and moisturization. It strengthens the skin barrier, increasing skin moisture content, and activates only moisture-friendly microbes. The composition can be used in creams, essences, lotions, and infusion waters to improve skin condition.

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A ternary probiotic factor composition for regulating skin microecological balance and its preparation method and use. The composition contains probiotics, prebiotics, and postbiotics. It aims to promote beneficial skin flora, improve skin health, and maintain a balanced microbiome. The probiotics are grown using prebiotics as nutrients. The composition can be used in cosmetics to regulate skin microbiota.

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A method and system for enhancing the skin microbiome through targeted skin contact formulations containing beneficial bacteria and other microbe components. The method involves administering a specific skin formulation containing beneficial bacteria and other microbe components to a newborn's skin, specifically within the first 6 hours of birth. This targeted approach enables the establishment of a healthy skin microbiome through early exposure to beneficial microorganisms, which is critical for immune system development and preventing skin diseases. The formulation is specifically designed to address particular skin concerns, such as acne, and can be administered through various delivery methods, including lotions, ointments, and sprays.

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Composition containing probiotics, particularly Lactobacillus, for preventing and treating inflammatory skin diseases like atopic dermatitis through modulating the skin microbiome. The composition, which can be used in topical formulations, employs a combination of probiotic strains that exhibit immunomodulatory effects on keratinocytes, particularly those involved in inflammation. The probiotics enhance the skin's natural barrier function and promote the restoration of the skin microbiota balance, thereby mitigating disease progression.

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Enhancing the health of an individual's skin microbiome to improve skin health through the use of modified bacteria and other skin contacting formulations. The method involves administering modified bacteria with desirable characteristics to specific skin regions, like newborns within hours of birth. The bacteria may be human-specific strains modified to reduce pathogenicity or enhance beneficial functions. Prebiotics and extracts are also applied to support the modified bacteria. The goal is to balance skin microbes for better skin health and disease prevention.

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A skin care composition that promotes skin microbiome balance through growth-enhancing compounds. The composition comprises a carbon source, such as pyruvic acid, pyruvate, lactic acid, lactate, or a combination thereof, along with a nitrogen source like urea or arginine, and a lipid source like caprylic/capric triglycerides. These components are combined in a skin care formulation that supports the growth of beneficial skin microorganisms, maintaining a healthy skin microbiome balance.

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A cosmetic treatment that utilizes Lactobacillus crispatus to reduce skin and mucous membrane pigmentation and prevent hyperpigmentation. The treatment involves applying a strain of Lactobacillus crispatus, specifically CNCM 1-5579, to the affected areas of the skin and mucous membranes. This strain has been found to inhibit melanin synthesis and prevent excessive melanin deposition, thereby reducing the appearance of hyperpigmentation and preventing its progression. The treatment can be applied topically in various forms, including powders, sticks, and lip balms, and can be used to treat phototype IV to VI skin.

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A probiotic composition comprising Lactobacillus plantarum, Lactobacillus rhamnosus, and Lactobacillus reuteri, which is effective in preventing and treating inflammatory, autoimmune, and allergic skin diseases. The composition combines these three probiotic strains in a synergistic manner, with Lactobacillus plantarum providing a broad-spectrum probiotic effect, Lactobacillus rhamnosus enhancing immune modulation, and Lactobacillus reuteri addressing specific skin barrier and immune system challenges. The composition is particularly beneficial for conditions like atopic dermatitis and acne, where these strains have been shown to exhibit potent anti-inflammatory and antimicrobial effects.

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Compositions containing probiotics for preventing and treating skin disorders like atopic dermatitis. The compositions contain specific strains of lactic acid bacteria like Lactobacillus paracasei and Lactobacillus acidophilus. These probiotics have anti-inflammatory and immunomodulatory effects on skin cells. The compositions can also contain amino acids, vitamins, minerals, enzymes, and prebiotics to support skin health.

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A probiotic composition that selectively targets and inhibits pathogenic bacteria while promoting beneficial microbial growth, enhancing skin barrier function, and regulating inflammation. The composition contains a specific strain of Lactobacillus plantarum and Lactobacillus fermentum, which exhibit enhanced antimicrobial activity against Staphylococcus aureus and Propionibacterium acnes compared to their single bacterial counterparts. The composition also exhibits potent antioxidant activity, up-regulates barrier repair genes, and modulates inflammatory responses.

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A composition comprising a lactic acid bacteria complex strain as an active ingredient, and more specifically, Bacillus (Bacillus sp.) pfbarrier 01 (KCTC 14628BP), Lactobacillus Pentosus (Lactobacillus pentosus) pfbio035 (KCTC 14684BP) and Lactobacillus sake (Lactobacillus sakei subsp.sakei) It relates to a composition comprising three complex strains of pfbio005 (KCTC 14130BP), a culture thereof, or a complex extract thereof as an active ingredient, and showing skin wrinkle improvement, moisturizing, skin barrier strengthening, and skin wound regeneration activity.

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Antioxidant, anti-inflammatory and whitening cosmetic composition that can be used for the production of functional cosmetics and functional foods. The composition includes lactic acid bacteria derived from human skin having antioxidant, anti-inflammatory or whitening activities.

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A skin care composition that promotes the development of a healthy skin microbiome through targeted application of growth-enhancing compounds that support the growth of beneficial microorganisms in the skin microbiome. The composition contains a carbon source, such as glucose, fructose, or pyruvic acid, and a nitrogen source, such as arginine, that are metabolized by microorganisms in the skin microbiome, thereby supporting their growth. The composition also contains a lipid source, such as caprylic/capric triglycerides, to support the growth of microorganisms. The composition maintains a low osmolality of 4000 mOsm/kg of water or less, which is crucial for bacterial metabolism and viability.

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Combined oral probiotic and topical ectoine treatment for gut-skin dysbiosis and related skin diseases. The oral probiotic composition contains specific strains like Lactobacillus plantarum, Lactobacillus rhamnosus, and Lactobacillus reuteri. The topical ectoine composition is applied to the skin. Administering the probiotic orally and ectoine topically together addresses gut-skin dysbiosis to improve skin appearance by reducing sebum, inflammation, and acne.

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Composition containing Lactobacillus and its use for preventing and/or improving skin aging, particularly wrinkles, fine lines, spots, or sagging on the skin caused by glycation stress that increases with aging. The composition comprises Lactobacillus plantarum (Lactobacillus plantarum), Bifidobacterium lactis (Bifidobacterium lactis) or a combination thereof, for preventing and/or improving anti-aging of skin.

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Probiotic postbiotic product that can improve skin condition and an application thereof in promoting skin health. The product includes inactivated thallus and metabolite thereof after fermentation of probiotics, the probiotics at least comprise lactobacillus paracasei Probiosci-101 and lactobacillus fermentum ProSci-602; the preservation number of the lactobacillus paracasei Probiosci-101 is CGMCC No.25085, and the preservation number of the lactobacillus fermenti ProSci-602 is CGMCC No.25451.

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Cosmetic and therapeutic formulations containing genetically modified bacteria that can ameliorate the harmful effects of pathogenic bacteria while enhancing the skin's natural microbiome. The formulations contain a genetically engineered strain of Cutibacterium acnes with growth arrest capabilities, combined with an anhydrous formulation of the bacteria in an inactive state. The formulation maintains the growth-arrested bacteria for at least six months and up to two years, while maintaining a balance of beneficial and pathogenic microorganisms in the skin.

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A skin quality improving agent containing Lactobacillus rhamnosus cells or extracts, and an external preparation for skin containing the agent. The Lactobacillus rhamnosus cells improve skin barrier function, resistance to bacteria, and suppress trans-epidermal water loss (TEWL). It does this by promoting expression of genes like HBEGF (growth factor), HAS3 (hyaluronic acid synthase), and CLDN1 (tight junction protein) in the skin. The agent can be used to improve skin functions like barrier, bacteria resistance, and TEWL suppression.

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A composition containing lactobacillus plantarum and/or bifidobacterium lactis to prevent and improve skin aging. The composition can be a food, cosmetic, or pharmaceutical product. The lactobacillus and/or bifidobacterium are cultured in a medium and then freeze-dried. The composition can also contain plant extracts or compounds that improve skin turnover and inhibit glycation.

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Composition for improving skin conditions, particularly acne, through the beneficial effects of Lactobacillus plantarum CJLP55, which exhibits enhanced growth inhibition and skin barrier repair capabilities compared to other strains. The composition combines Lactobacillus plantarum CJLP55 with a culture solution, demonstrating improved skin health through enhanced sebum reduction, improved skin barrier function, and reduced inflammation.

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Anti-inflammatory, anti-allergic, skin microbial control and skin soothing uses that suppresses or can be reduced. The strain inhibits or reduces the expression of inflammation-related genes (eg, COX-2, iNOS); increase skin beneficial bacteria (eg, S. epidermidis ) while decreasing skin harmful bacteria (eg P. aeruginosa, S. aureus ) by including the Lactobacillus plantarum strain, a lysate thereof, a culture solution, an extract of the culture solution, a fermentation broth, or any combination thereof, thereby suppressing or can be reduced.

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Probiotic bacteria and their lysates for topical application in treating skin conditions, including barrier repair and infection prevention. The probiotic bacteria, specifically Lactobacillus rhamnosus GG, form a therapeutic agent when used in a lysate form. This probiotic bacterium, along with its lysate, can be applied directly to the skin to enhance barrier function, prevent infections, and promote tissue repair. The probiotic bacterium's lysate can be formulated into topical preparations, including creams, ointments, and gels, for direct application to the skin.

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Cosmetic composition for preventing or improving skin aging that includes cultures of lactic acid bacteria strains Lactobacillus plantarum Wikim 125, Lactobacillus plantarum Wikim 126, and Lactobacillus plantarum Wikim 1

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Skin care composition that improves the barrier function of the skin and the distribution of microorganisms on the skin surface. The composition contains inulin/yogurt powder, rose extract, peptide, bacillus ferment, lactic acid bacterium culture lysate, and lactic acid bacterium/eriodicthione calihornicum ferment. It is a unique blend of skin-absorbable ingredients that synergistically improves skin barrier and microbiome. Adding this composition to cosmetics enhances their microbiome benefits.

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A probiotic skin care product that reduces skin sensitization and enhances skin barrier function through the synergistic action of Lactobacillus rhamnosus and Lactobacillus delbrueckii. The product combines a probiotic freeze-dried powder with recombinant human epidermal growth factor (hEGF) in a 2:1:1 ratio, providing potent anti-inflammatory and immunomodulatory effects. This formulation has been shown to inhibit skin allergy and inflammation, regulate immune responses, and improve skin barrier function, making it particularly effective in reducing skin sensitization and promoting skin health.

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A composition for anti-inflammatory, skin moisturizing, skin barrier strengthening, and skin regeneration promotion that contains a Lactobacillus rhamnosus strain, culture medium, or extract thereof. The strain, identified as Lactobacillus rhamnosus mesopharm001 (Accession No. KCTC 14350BP), was found to have anti-inflammatory, skin moisturizing, skin barrier strengthening, and skin regeneration properties. The composition can be used in cosmetics to improve skin condition by addressing issues like inflammation, dryness, barrier function, and wound healing. The strain's extracts can be used in cosmetics to provide these skin benefits.

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Composition for soothing and repairing sensitive skin. The composition contains synbiotics (prebiotic bacteria and fermentation products), irritation inhibitors, sebum mimics, and damaged repair components. The synbiotics promote a healthy skin microbiome. The irritation inhibitors soothe sensitive skin. The sebum mimics replenish skin lipids. The damaged repair components help repair skin barriers. The composition is intended to address the root causes of sensitive skin by balancing the skin microbiome and restoring barrier function.

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Lactobacillus Fermentum subspecies Seva-101 strain is a novel lactic acid bacteria that can be used in the manufacture of functional cosmetics and functional foods having skin barrier strengthening and anti-wrinkle activity. The strain has excellent skin barrier improvement and anti-wrinkle activity.

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Lactobacillus plantarum subspecies seba-202 strain having skin barrier strengthening and anti-wrinkle activity. The strain isolates a novel lactic acid bacteria that can be used in the production of functional cosmetics and functional foods. The strain isolates a novel lactic acid bacteria that has skin barrier strengthening and anti-wrinkle activity.

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A method for enhancing skin microbiome health through targeted microbial colonization. The method employs a novel formulation of beneficial skin microorganisms, specifically tailored to address skin-specific microbial imbalances, to establish a balanced skin microbiome. The formulation is administered to the skin in a specific concentration and timing, with the critical window of colonization occurring within the first 24 hours after birth. This early colonization window is critical for establishing immune tolerance to commensal skin microorganisms, preventing allergic reactions and chronic skin conditions. The formulation comprises a combination of beneficial bacteria, including Propionibacterium, Lactobacillus, and Bacteroides, that are specifically adapted to the skin environment. The formulation is delivered through a topical application, such as a lotion or ointment, and is designed to promote a healthy balance of skin microbiota, while preventing pathogenic colonization.

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Composition for external application to the skin containing probiotics in an active state. The composition comprises a probiotic powder, an oil phase comprising a cationic oil; and an aqueous phase comprising an anionic thickener. The probiotic powder is supported in the oil phase, where the probiotics are protected from water by encapsulating them and protecting them from aqueous phase.

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Moisturizing and repairing composition for improving dry and aging skin. The composition contains fermentation products of bifidobacteria and lactic acid bacteria, vitamin E derivatives, and other ingredients like glycerin and butanediol. It intensively moisturizes, improves dryness, fine lines, roughness, and firmness of dry and aging skin. The fermentation products provide beneficial skin care compounds like amino acids, peptides, vitamins, and polysaccharides.

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Composition for preventing, attenuating, or treating skin aging, immune defense reduction, and inflammation using probiotics and hyaluronic acid. The composition contains probiotic bacteria like Lactobacillus paracasei and hyaluronic acid to promote skin health and defense. It can be used to prevent natural aging, aging from UV exposure, reduce immune defense deficiencies, and treat inflammation and skin conditions caused by pathogens.

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A skin care composition containing a strain of Lactobacillus plantarum GMNL-6 that promotes collagen secretion and ceramide synthesis in human skin fibroblasts. The composition is a topical emulsion or lotion that can be applied to the skin to improve its condition and appearance. The Lactobacillus strain is dead, and its application promotes collagen production and ceramide synthesis in the skin.

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Probiotic composition for personal care products like shampoo and conditioner that provides antidandruff and antipruritic benefits. The composition contains lactic acid bacteria powder, bacterial ferment lysate, plant extracts, corn starch, and water. The lactic acid bacteria produce organic acids to lower pH, inhibit pathogens, and boost immunity. The plant extracts provide antibacterial and anti-inflammatory effects. The composition balances scalp microbiota and soothes itch.

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A composition containing a combination of three strains of lactic acid bacteria - Lactobacillus fermentum, Lactobacillus rhamnosus, and Lactobacillus reuteri - as an active ingredient. The composition exhibits antibacterial, skin moisturizing, anti-atopic, skin barrier strengthening, and wrinkle improvement activities. The bacteria strains are isolated from the vagina of healthy women. The composition can be used for vaginitis treatment, as well as for improving skin conditions like inflammation, moisture retention, barrier function, and wrinkles.

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A composition containing a specific Lactobacillus sakei strain, its culture medium, or extract for improving skin elasticity, reducing wrinkles, promoting wound healing, and strengthening the skin barrier. The strain, identified as Lactobacillus sakei blanc001 (Accession No. KCTC 14206BP), increases collagen synthesis and inhibits collagen-degrading enzymes. It also promotes wound healing and enhances filaggrin gene expression for skin barrier strengthening. The strain extract has no skin irritation.

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A product for regulating the skin microbiome to improve skin health and reduce body odor by using probiotics. The product contains probiotics like Lactobacillus, olive oil, glycerin, and water. The probiotics compete with harmful bacteria on the skin to improve the microbiome balance and reduce odor-causing bacteria like Staphylococcus aureus. The product can be used in soap, shampoo, conditioner, gel, cleanser, and perfume to regulate skin microbiomes for improved skin health and reduced body odor.

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Composition for improving sensitive skin that combines internal probiotics and external skincare products. The composition includes an oral probiotic composition and an external skin care composition. The oral probiotic composition contains strains like Lactobacillus paracasei, Lactobacillus rhamnosus, and Lactobacillus retortoides, along with polysaccharides like maltodextrin. The external skin care composition contains probiotic fermentation products, ceramide-like components, polysaccharides, and plant extracts. The internal probiotics and external skincare products work together to improve sensitive skin by regulating intestinal health and protecting the skin barrier.

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An active probiotic facial mask liquid that can improve skin health and appearance. The mask liquid contains active probiotic bacteria, along with other ingredients like hyaluronic acid, allantoin, and biotin. The probiotics help soften and decompose skin cutin, while the other ingredients lock in moisture and protect against oxidation. The mask liquid is applied to the skin for 15-20 minutes, then washed off.

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A composition comprising a Lactobacillus crustorum strain, its extract, or culture that enhances skin health through its beneficial effects on ceramide synthesis, skin barrier function, and regeneration. The composition can be used for skin regeneration, texture improvement, moisturizing, elasticity enhancement, and barrier strengthening. The strain, identified as Lactobacillus crustorum JTA, has been found to promote ceramide synthesis and improve skin barrier function, making it a valuable ingredient for skin care applications.

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A composition for controlling microorganisms on the skin that balances the growth of beneficial and harmful bacteria. The composition combines nisin, lysozyme, and a fermented lactobacillus strain (Lactobacillus paraplantarum) in a synergistic blend. The lactobacillus strain enhances beneficial skin bacteria while inhibiting harmful bacteria, creating a balanced ecosystem that supports skin health.

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A probiotic composition for repairing skin that can be added to cosmetics to improve skin health. The composition contains lactobacillus fermentation product, schizosaccharomyces fermentation product lysate, rice fermentation product filtrate, pear juice fermentation product filtrate, humectant, emollient, emulsifier and deionized water. The composition is prepared by mixing these components in a specific ratio and sterilizing the mixture. The composition can be added to cosmetics like cream, essence, toner and emulsion to improve skin health.

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