Minoxidil Nanocarrier Development for Enhanced Follicular Penetration

Minoxidil loaded on porous titanium dioxide nanoparticles for preventing hair loss and promoting hair growth. The nanoparticles protect and deliver minoxidil to the hair follicles more effectively than free minoxidil, reducing side effects and increasing efficacy. The nanoparticles are synthesized using a templating method where a polymer is coated with titanium dioxide particles, then sintered to remove the template. Minoxidil is loaded onto the resulting hollow porous nanoparticles.

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Composition for treating hair loss containing minoxidil with enhanced skin penetration. The composition employs a skin penetration enhancer, specifically a propylene glycol fatty acid ester, to improve minoxidil delivery through the skin. This formulation combines minoxidil with surfactants, humectants, pH adjusters, and antioxidants to create a stable and effective hair loss treatment. The composition can be formulated as a liquid or foam aerosol, providing a convenient and efficient solution for hair loss treatment.

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A pharmaceutical composition for treating androgenic alopecia that combines minoxidil with tocopherol acetate. The composition, comprising minoxidil and tocopherol acetate, delivers enhanced bioavailability and local efficacy through a synergistic mechanism. The tocopherol acetate component, known for its antioxidant properties, specifically promotes the expression of sulfotransferase, the enzyme responsible for converting minoxidil into its active form. This targeted delivery system enhances penetration and retention of minoxidil in the hair follicle, overcoming common limitations of minoxidil formulations. The composition is particularly effective for patients with androgenetic alopecia, where minoxidil's efficacy is often compromised by low bioavailability and poor penetration.

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A minoxidil nanocrystal suspension for hair growth that addresses the limitations of conventional formulations. The nanocrystal suspension comprises minoxidil, vitamin E polyethylene glycol succinate, D-trehalose, and water, with a specific composition optimized for enhanced solubility, bioavailability, and safety. The formulation achieves a stable, clinically relevant concentration of minoxidil while maintaining the suspension's physical properties and preventing skin irritation.

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A minoxidil nanocrystal suspension composition and method that enables the preparation of minoxidil-based hair growth treatments with improved solubility and bioavailability. The composition comprises minoxidil, vitamin E polyethylene glycol succinate, D-trehalose, and water, with the latter serving as a stabilizing agent. The nanocrystal suspension is prepared through a controlled mixing process that incorporates the stabilizing agent with the minoxidil and vitamin E polyethylene glycol succinate, followed by ultrasonic treatment and bead milling. This formulation achieves the desired nanocrystal size and particle size distribution, enabling effective topical application of minoxidil for hair growth.

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An anti-hair loss nanocomposition containing modified starch, minoxidil-like compounds, emulsifiers, stabilizers, organic solvents, and water. The modified starch like amylose-g-DEAEMA or amylose-g-MPC is used to encapsulate the hydrophobic minoxidil-like compounds. The nanocomposition has improved solubility, encapsulation efficiency, and skin compatibility compared to traditional formulations. The modified starch provides a hydrophilic matrix for the minoxidil-like compounds to reduce irritation and improve scalp repair when applied topically for hair loss treatment.

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A method for preparing a stable and effective minoxidil-based topical solution for hair growth. The preparation involves dissolving minoxidil with a glacial acetic acid aqueous solution, followed by the addition of lecithin and homogenization. The resulting solution is then formulated into a topical product with improved stability, penetration, and bioavailability compared to conventional minoxidil preparations. The formulation achieves a particle size of 72.45-78.37 nm, a particle size distribution (PDI) of 0.24-0.26, and a zeta potential of -51.42-50.68 mV, while maintaining a loading capacity of 92.36-94.62% minoxidil.

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Nanostructured lipid carriers (NLCs) for minoxidil delivery that achieve stable, non-toxic, and effective drug delivery. The NLCs contain minoxidil, which is stored in their nanoparticles, with a size range of 100-500 nm. The carriers are prepared using a novel lipid composition that balances stability, non-toxicity to skin cells, and drug loading capacity. The NLCs retain their drug potency over extended periods and exhibit controlled release characteristics, making them suitable for treating hair loss conditions.

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A topical composition for promoting hair growth through enhanced activation of hair follicle epithelial stem cells. The composition comprises minoxidil microparticles at concentrations of 2-10 w/v%, dispersed in a cellulose-based polymer matrix, with average particle size of 50-200 nm. The microparticles contain a cellulosic polymer that facilitates their controlled release and stability in the scalp environment. The composition enables superior minoxidil delivery and activation of stem cells in the upper hair follicle, particularly in the bulge region, resulting in enhanced hair growth compared to conventional minoxidil formulations.

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A topical treatment for alopecia that simultaneously addresses hair loss through minoxidil, cyclosporine A, and a compound that binds FK506 binding protein 4 (FKBP4). The treatment combines a potent anti-hair loss agent with immunosuppressive properties and a hair growth promoter, providing a comprehensive solution for both alopecia and hair growth enhancement. The treatment formulation enables targeted delivery of these active ingredients to the scalp, potentially preventing alopecia while promoting hair growth.

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Nanoemulsion formulation for hair growth that combines flavone and emodin to promote hair follicle health. The formulation is prepared through a precise emulsification process that creates a stable nanoemulsion with a size range of 100nm. The emulsion is optimized to enhance skin penetration and bioavailability of the active ingredients, while maintaining their therapeutic efficacy. The nanoemulsion formulation is particularly effective for promoting hair growth through targeted delivery of flavone and emodin to the hair follicle.

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Composition and method for enhancing topical delivery of active agents through a novel particle structure that combines a liquid core with a hydrophobic shell. The core contains an alkaline solubility-enhancing agent and acid-stabilizing agent, while the shell comprises hydrophobic particles that form a stable liquid droplet upon mechanical stress. This unique particle structure enables controlled release of the active agent as a liquid or gel, while maintaining stability and preventing premature separation.

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A topical treatment for alopecia that combines a potent anti-hair loss agent with a novel delivery system. The treatment comprises a 5% solution of a potent anti-hair loss agent, which is formulated with a proprietary delivery system that enhances its penetration into the hair follicle. The solution is prepared by combining the anti-hair loss agent with a delivery system that includes a combination of propylene glycol, diethylene glycol monoethyl ether, and hyaluronate. The solution is then formulated into a 50ml clear solution that is free of bacteria and other contaminants.

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Chitosan microparticles encapsulating minoxidil for targeted, sustained release in topical formulations. The microparticles contain 25-50% minoxidil encapsulated within chitosan matrix, with chitosan used as the primary polymer. The microparticles exhibit controlled release properties, with iontophoretic delivery maintaining drug concentration in the skin. The formulation maintains its integrity upon skin penetration, with iontophoretic ion channeling facilitating drug entry while maintaining particle structure.

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A nanocomposite for treating androgenic alopecia that combines diamino pyridine oxide and pyrrolidinyl diamino pyridine oxide with enhanced hair growth properties. The nanocomposite contains a balance of water-soluble and lipid-soluble components, including diamino castanate oxide, pyrrolidinyl diamino castanate oxide, and their derivatives. The nanocomposite delivers multiple anti-hair loss mechanisms, including anti-dropping and anti-androgenic effects, through targeted penetration into hair follicles. The nanocomposite formulation achieves improved skin penetration and bioavailability compared to conventional treatments, with enhanced stability and controlled release of active ingredients.

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Topical minoxidil formulations for hair growth that enhance skin permeability without causing keratinization. The composition includes minoxidil, solubilizing agents, surfactants, and a specific oil component that improves skin penetration. This formulation addresses the conventional limitations of minoxidil formulations by targeting skin barrier function while delivering the vasodilator. The oil component specifically enhances skin permeability, allowing minoxidil to reach the hair follicles without causing keratinization. The formulation enables effective hair growth through controlled penetration of minoxidil into the scalp.

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Hair growth composition containing minoxidil, which provides localized treatment for hair loss and promotes hair growth. The composition comprises multilamellar vesicles containing a hair growth compound and an acid C8-C24 alcohol ester. The multilamellar vesicles deliver the active ingredients through targeted skin penetration, while the acid C8-C24 alcohol ester enhances the delivery process. The composition is suitable for topical application and has been shown to accelerate hair growth and increase terminal hair appearance in mammals.

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A positively charged anti-desorption composite flexible liposome for treating androgenetic alopecia, comprising a liposome formulation that combines a positively charged anti-desorption complex with a multi-target mechanism. The liposome encapsulates a combination of linoleic acid, glycyrrhizic acid, glutathione, sphingosine, and matrine, which target androgen receptor activity, 5α-reductase inhibition, and sebaceous gland function. The liposome's positive charge enhances its interaction with negatively charged human hair, facilitating penetration into the hair follicle and promoting hair growth.

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Pharmaceutical composition for treating alopecia that utilizes polymeric nanoparticles containing finasteride and minoxidil as therapeutic agents. The composition comprises polymeric nanoparticles, preferably nanocapsoids, containing finasteride and minoxidil, a pharmaceutically acceptable vehicle; and optionally additives. The polymeric nanoparticles are prepared through a controlled interfacial deposition process, specifically by forming the organic and aqueous phases through a combination of polymerization and solvent evaporation. The composition is in the form of a solution, gel, or lotion for topical administration.

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