Minoxidil Nanocarrier Development for Enhanced Follicular Penetration

Minoxidil loaded on porous titanium dioxide nanoparticles for preventing hair loss and promoting hair growth. The nanoparticles protect and deliver minoxidil to the hair follicles more effectively than free minoxidil, reducing side effects and increasing efficacy. The nanoparticles are synthesized using a templating method where a polymer is coated with titanium dioxide particles, then sintered to remove the template. Minoxidil is loaded onto the resulting hollow porous nanoparticles.

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Composition for treating hair loss containing minoxidil with enhanced skin penetration. The composition employs a skin penetration enhancer, specifically a propylene glycol fatty acid ester, to improve minoxidil delivery through the skin. This formulation combines minoxidil with surfactants, humectants, pH adjusters, and antioxidants to create a stable and effective hair loss treatment. The composition can be formulated as a liquid or foam aerosol, providing a convenient and efficient solution for hair loss treatment.

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A pharmaceutical composition for treating androgenic alopecia that combines minoxidil with tocopherol acetate. The composition, comprising minoxidil and tocopherol acetate, delivers enhanced bioavailability and local efficacy through a synergistic mechanism. The tocopherol acetate component, known for its antioxidant properties, specifically promotes the expression of sulfotransferase, the enzyme responsible for converting minoxidil into its active form. This targeted delivery system enhances penetration and retention of minoxidil in the hair follicle, overcoming common limitations of minoxidil formulations. The composition is particularly effective for patients with androgenetic alopecia, where minoxidil's efficacy is often compromised by low bioavailability and poor penetration.

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A minoxidil nanocrystal suspension for hair growth that addresses the limitations of conventional formulations. The nanocrystal suspension comprises minoxidil, vitamin E polyethylene glycol succinate, D-trehalose, and water, with a specific composition optimized for enhanced solubility, bioavailability, and safety. The formulation achieves a stable, clinically relevant concentration of minoxidil while maintaining the suspension's physical properties and preventing skin irritation.

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A minoxidil nanocrystal suspension composition and method that enables the preparation of minoxidil-based hair growth treatments with improved solubility and bioavailability. The composition comprises minoxidil, vitamin E polyethylene glycol succinate, D-trehalose, and water, with the latter serving as a stabilizing agent. The nanocrystal suspension is prepared through a controlled mixing process that incorporates the stabilizing agent with the minoxidil and vitamin E polyethylene glycol succinate, followed by ultrasonic treatment and bead milling. This formulation achieves the desired nanocrystal size and particle size distribution, enabling effective topical application of minoxidil for hair growth.

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An anti-hair loss nanocomposition containing modified starch, minoxidil-like compounds, emulsifiers, stabilizers, organic solvents, and water. The modified starch like amylose-g-DEAEMA or amylose-g-MPC is used to encapsulate the hydrophobic minoxidil-like compounds. The nanocomposition has improved solubility, encapsulation efficiency, and skin compatibility compared to traditional formulations. The modified starch provides a hydrophilic matrix for the minoxidil-like compounds to reduce irritation and improve scalp repair when applied topically for hair loss treatment.

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A method for preparing a stable and effective minoxidil-based topical solution for hair growth. The preparation involves dissolving minoxidil with a glacial acetic acid aqueous solution, followed by the addition of lecithin and homogenization. The resulting solution is then formulated into a topical product with improved stability, penetration, and bioavailability compared to conventional minoxidil preparations. The formulation achieves a particle size of 72.45-78.37 nm, a particle size distribution (PDI) of 0.24-0.26, and a zeta potential of -51.42-50.68 mV, while maintaining a loading capacity of 92.36-94.62% minoxidil.

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Nanostructured lipid carriers (NLCs) for minoxidil delivery that achieve stable, non-toxic, and effective drug delivery. The NLCs contain minoxidil, which is stored in their nanoparticles, with a size range of 100-500 nm. The carriers are prepared using a novel lipid composition that balances stability, non-toxicity to skin cells, and drug loading capacity. The NLCs retain their drug potency over extended periods and exhibit controlled release characteristics, making them suitable for treating hair loss conditions.

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A novel approach for enhancing topical delivery of retinoid drugs like tretinoin through gel formulation. The method involves creating nanocrystals of tretinoin that are loaded into a gel matrix. The nanocrystals are prepared through a controlled precipitation process that optimizes their size, polydispersity index, and drug content. The gel matrix is formulated with a stabilizer and anti-solvent system to maintain the nanocrystals' integrity during storage and delivery. The nanocrystals' enhanced solubility and stability in the gel matrix significantly improve their topical penetration compared to conventional formulations.

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A topical composition for promoting hair growth through enhanced activation of hair follicle epithelial stem cells. The composition comprises minoxidil microparticles at concentrations of 2-10 w/v%, dispersed in a cellulose-based polymer matrix, with average particle size of 50-200 nm. The microparticles contain a cellulosic polymer that facilitates their controlled release and stability in the scalp environment. The composition enables superior minoxidil delivery and activation of stem cells in the upper hair follicle, particularly in the bulge region, resulting in enhanced hair growth compared to conventional minoxidil formulations.

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Tretinoin-loaded nanostructured delivery system for topical application, which enhances bioavailability and skin penetration by overcoming the limitations of conventional formulations. The system comprises a nanostructured matrix of tretinoin-loaded nanoparticles, which are prepared through a low-energy anti-solvent precipitation method. The nanoparticles are formulated using a solvent that selectively precipitates the tretinoin while maintaining its high drug loading capacity, resulting in improved drug retention and bioavailability compared to conventional formulations. The nanostructured matrix is characterized by its high drug loading, uniform particle size, and improved solubility, enabling enhanced skin penetration and improved therapeutic efficacy.

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A topical treatment for alopecia that simultaneously addresses hair loss through minoxidil, cyclosporine A, and a compound that binds FK506 binding protein 4 (FKBP4). The treatment combines a potent anti-hair loss agent with immunosuppressive properties and a hair growth promoter, providing a comprehensive solution for both alopecia and hair growth enhancement. The treatment formulation enables targeted delivery of these active ingredients to the scalp, potentially preventing alopecia while promoting hair growth.

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Nanoemulsion formulation for hair growth that combines flavone and emodin to promote hair follicle health. The formulation is prepared through a precise emulsification process that creates a stable nanoemulsion with a size range of 100nm. The emulsion is optimized to enhance skin penetration and bioavailability of the active ingredients, while maintaining their therapeutic efficacy. The nanoemulsion formulation is particularly effective for promoting hair growth through targeted delivery of flavone and emodin to the hair follicle.

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A nano-composite for preventing hair loss, promoting hair growth, and fixing black hair through synergistic action of hair growth promoters, hair-fixing peptides, and black hair peptides. The nano-composite is a combination of diaminopyridine oxide, pyrrolidinyl diaminopyridine oxide, hair-growth peptides, hair-fixing peptides, and black hair peptides, which form a lipid bilayer structure that penetrates the skin's stratum corneum, interacts with keratin, and promotes active substance penetration into the hair follicle. The nano-composite provides enhanced anti-hair loss, anti-hair growth, and anti-black hair effects compared to conventional treatments, with a low content of active ingredients.

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Hair growth agent containing sponge spicules for promoting hair growth through targeted delivery of therapeutic agents to hair follicles. The agent comprises a hair growth agent encapsulated within sponge spicules, which are engineered to selectively penetrate the hair follicle environment while maintaining their structural integrity. This innovative delivery system enables controlled release of therapeutic agents to the hair follicle, bypassing the skin barrier and promoting hair growth through targeted action on hair follicle function.

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Preparation of a stem cell growth factor for protecting and inducing hair follicle regeneration through enhanced expansion and specific stimulation of human adipose-derived mesenchymal stem cells. The method involves optimizing stem cell expansion through controlled ascorbic acid treatment, followed by targeted minoxidil treatment to enhance paracrine secretion of growth factors and cytokines that promote hair follicle regeneration. This approach enables the rapid secretion of potent hair growth factors that can be used to treat androgenetic alopecia.

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Composition and method for enhancing topical delivery of active agents through a novel particle structure that combines a liquid core with a hydrophobic shell. The core contains an alkaline solubility-enhancing agent and acid-stabilizing agent, while the shell comprises hydrophobic particles that form a stable liquid droplet upon mechanical stress. This unique particle structure enables controlled release of the active agent as a liquid or gel, while maintaining stability and preventing premature separation.

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A topical treatment for alopecia that combines a potent anti-hair loss agent with a novel delivery system. The treatment comprises a 5% solution of a potent anti-hair loss agent, which is formulated with a proprietary delivery system that enhances its penetration into the hair follicle. The solution is prepared by combining the anti-hair loss agent with a delivery system that includes a combination of propylene glycol, diethylene glycol monoethyl ether, and hyaluronate. The solution is then formulated into a 50ml clear solution that is free of bacteria and other contaminants.

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A topical formulation of 5% minoxidil for treating male pattern baldness that combines enhanced skin penetration with improved bioequivalence. The formulation incorporates propylene glycol, diethylene glycol monoethyl ether, and sodium hyaluronate to enhance solubility and stability, while maintaining the potent vasodilatory effects of minoxidil. The formulation achieves a consistent concentration of minoxidil (90-110%) through precise formulation control, with microbiological testing confirming sterility and safety.

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Nanoemulsion for promoting hair growth containing pyrrolidinyl diamino pyrimidine oxide and bacoside, with a specific mass ratio of 5:2. This emulsion improves hair growth through two distinct mechanisms: pyrrolidinyl diamino pyrimidine oxide, which antagonizes potassium ion channel switch inhibitors, and bacoside, a potent androgen receptor antagonist. The emulsion combines with lecithin, polyoxyethylene castor oil, ethyl oleate ester, glutathione, ethanol, pyrrolidinyl diamino pyrimidine oxide, bacoside, phenoxyethanol, and water to create a stable and effective cosmetic product for promoting hair growth.

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