Microbiome-Friendly Formulations for Skin Health

A composition for regulating skin microecological balance that promotes healthy skin by improving skin microbiome diversity. The composition contains five ingredients: lactobacillus/soybean milk fermentation product filtrate, inulin, alpha-glucan oligosaccharides, red pine leaf extract, and lactobacillus fermentation product. The ingredients synergistically promote probiotic growth, inhibit harmful bacteria, eliminate biofilms, and reduce quorum sensing to achieve overall skin microbiome balance. The composition is useful in skin care products to enhance skin barrier, control oil, relieve irritation, and repair skin.

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Compositions containing human milk oligosaccharides (HMOs) for reducing inflammation, irritation, and improving skin health. The compositions can be used as pharmaceuticals to treat skin conditions like psoriasis, acne, rosacea, eczema, or UV radiation-induced inflammation, or as cosmetics to enhance skin appearance, reduce wrinkles, increase firmness, elasticity, hydration, and anti-aging effects. The HMOs can be formulated with squalane, carboxymethyl cellulose, lecithin, glyceride, etc.

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A composition for regulating skin microecology and repairing skin barrier that effectively inhibits Propionibacterium acnes and Staphylococcus aureus while maintaining skin health. The composition contains specific synergistic amounts of Streptococcus mitis fermentation product, α-glucan oligosaccharide, isomaltooligosaccharide, oat β-glucan, and inulin. This combination provides potent antimicrobial activity against acne-causing bacteria while preserving the skin's natural barrier function.

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Composition that regulates specific skin microorganisms to achieve anti-inflammatory effects through fermentation. The composition comprises lactate, sugars, and nitrogen sources as fermentation substrates, which inhibit inflammatory cytokines like IL-1β and TLR4 in the skin microbiome. The composition is engineered to selectively target and modulate skin microorganisms while maintaining a balance of beneficial microbiota, providing sustained anti-inflammatory effects.

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A method for generating a high-quality, low-latency video stream from a low-latency, high-resolution video source. The method involves processing the source video stream to remove unnecessary metadata and compression artifacts, while maintaining its original quality. This is achieved through a series of adaptive quantization and compression steps that adaptively adjust the quantization levels and compression parameters based on the video content's characteristics. The method employs a combination of quantization and compression techniques, including adaptive quantization and variable-length coding, to achieve optimal trade-offs between quality and latency.

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A skin care composition that promotes skin health by maintaining the natural balance of bacteria on the skin. The composition contains 1,3-propanediol as an active ingredient. It can also contain boosting ingredients like fructan and yeast extract. Applying this composition topically to the skin increases beneficial bacteria like Staphylococcus epidermidis while reducing harmful bacteria like Staphylococcus aureus. This helps maintain a healthy skin microbiome.

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Cosmetic composition for maintaining and restoring skin flora balance. It contains a combination of oligosaccharides and polysaccharides like inulin, fructooligosaccharides, glucooligosaccharides, and mannose monosaccharides. This composition reduces skin bacteria load and diversity after external attacks. It also prevents and treats dry, rough, and sensitive skin. The oligosaccharides and polysaccharides are prebiotics that selectively feed beneficial skin bacteria to maintain a healthy flora.

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Balancing the skin microbiota through a cosmetic composition that incorporates short-chain fructo-oligosaccharides and native starches. The composition, comprising a cosmetically acceptable carrier, contains at least one short-chain fructo-oligosaccharide and at least one native starch. The short-chain fructo-oligosaccharide is derived from sugar beet and has a degree of polymerization of 3, while the native starch is derived from corn and is a product of enzymatic hydrolysis. The composition is used to restore skin microbiota balance, particularly in cases of dysbiosis, by promoting beneficial bacterial growth and reducing pathogenic species.

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Using specific fatty acids and compositions containing them to promote a healthy skin microbiome. The fatty acids, like C18 to C24, are applied to skin to selectively support growth of beneficial commensal bacteria like Staphylococcus epidermidis and Staphylococcus hominis. This helps maintain a balanced microbiome to protect against harmful bacteria. The fatty acids can be used alone or in personal care products at concentrations up to 10% to enhance commensal bacterial growth.

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Composition for improving skin microbiota containing monopalmitin or its derivatives to selectively promote beneficial bacteria growth while inhibiting harmful bacteria growth. The composition selectively inhibits the growth of harmful bacteria while activating beneficial bacteria growth, particularly targeting Staphylococcus aureus and Staphylococcus epidermidis.

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Skin care composition with low osmolality that preserves skin microbiome stability. The composition has an osmolality of 4000 mOsm/kg water or less, comprising reduced amounts of solutes like NaCl, KCl, CaCl2, and MgCl2, and contains lactate as a carbon source. This formulation maintains skin microbiome balance while minimizing osmotic stress, making it suitable for therapeutic and cosmetic applications.

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A skin microecological supplement composition to improve skin health by balancing the skin microbiome. The composition contains extracts from rhodiola rosea, snow lotus, white birch sap, and aloe vera fermented with yeast, along with a microbial lysate. The fermented extracts provide nutrients and the lysate contains live bacteria. This combination aims to enhance skin barrier function, reduce inflammation, and promote skin repair by restoring the skin microbiome balance.

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Synchronic and bacterial-specific treatments for acne that reduces the risk of inflammation. The treatment includes using human specific species of bacteria that are modified to enhance one or more characteristics deemed beneficial to the skin microbiome and health of the individual, including bacteria that have been modified via a CRISPR-Cas9 and/or Cpf1 system to either repress the expression of a particular protein or lipid, or to increase the production of beneficial microbial secretions.

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Cosmetic composition that maintains or promotes beneficial skin microbiome without inhibiting beneficial bacteria growth. The composition comprises surfactant and oil, with the surfactant being a nonionic surfactant that does not inhibit beneficial bacteria growth. The composition is prepared by dissolving the surfactant in purified water, adding oil, and mixing to prepare a stable emulsion. This composition maintains beneficial bacteria populations without the need for prebiotics or probiotics, making it a novel approach to microbiome cosmetics.

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A method and system for enhancing the skin microbiome through targeted skin contact formulations containing beneficial bacteria and other microbe components. The method involves administering a specific skin formulation containing beneficial bacteria and other microbe components to a newborn's skin, specifically within the first 6 hours of birth. This targeted approach enables the establishment of a healthy skin microbiome through early exposure to beneficial microorganisms, which is critical for immune system development and preventing skin diseases. The formulation is specifically designed to address particular skin concerns, such as acne, and can be administered through various delivery methods, including lotions, ointments, and sprays.

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A skin care composition that promotes skin microbiome balance through growth-enhancing compounds. The composition comprises a carbon source, such as pyruvic acid, pyruvate, lactic acid, lactate, or a combination thereof, along with a nitrogen source like urea or arginine, and a lipid source like caprylic/capric triglycerides. These components are combined in a skin care formulation that supports the growth of beneficial skin microorganisms, maintaining a healthy skin microbiome balance.

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Chlamydomonas nivalis oligosaccharides that regulate skin microecology, obtained through biological fermentation technology, with potent anti-inflammatory and antimicrobial effects. These oligosaccharides inhibit harmful bacteria, modulate the skin barrier, and promote autophagy, making them suitable for cosmetic applications to soothe skin inflammation and restore skin health.

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Composition for promoting beneficial skin bacteria or suppressing harmful skin bacteria through the modulation of the skin microbiome. The composition contains an active ingredient that is excellent in promoting beneficial skin bacteria or suppressing harmful skin bacteria, and it was developed to significantly improve the effectiveness of promoting beneficial skin bacteria or suppressing harmful skin bacteria.

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Composition for enhancing beneficial skin bacteria or inhibiting harmful skin bacteria to regulate skin microbiome. The composition contains a skin-resident beneficial bacteria, such as Staphylococcus epidermidis, that promotes skin health by regulating the immune system and skin barrier function. The composition can be used to enhance beneficial skin bacteria or inhibit harmful skin bacteria, including Staphylococcus aureus, and to regulate beneficial skin bacteria and inhibit harmful skin bacteria.

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Compositions containing human-isolated or synthetic probiotic bacteria strains like Alcaligenes faecalis, Bacillus alcaligenes, Bacillus pumilus, Bacillus subtilis, and Bacillus indigo, and their metabolites, cell lysates, and postbiotics for treating, inhibiting, and preventing skin disorders caused by pathogenic microbes. The probiotics are derived from healthy human skin to improve skin health and combat skin infections. The compositions can be topical applications for treating conditions associated with skin pathogens like dermatophytes, yeasts, and fungi. They can be used as pharmaceuticals, cosmetics, or oral supplements.

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