Microbiome-Friendly Formulations for Skin Health

A composition for regulating skin microecological balance that promotes healthy skin by improving skin microbiome diversity. The composition contains five ingredients: lactobacillus/soybean milk fermentation product filtrate, inulin, alpha-glucan oligosaccharides, red pine leaf extract, and lactobacillus fermentation product. The ingredients synergistically promote probiotic growth, inhibit harmful bacteria, eliminate biofilms, and reduce quorum sensing to achieve overall skin microbiome balance. The composition is useful in skin care products to enhance skin barrier, control oil, relieve irritation, and repair skin.

Source

Compositions containing human milk oligosaccharides (HMOs) for reducing inflammation, irritation, and improving skin health. The compositions can be used as pharmaceuticals to treat skin conditions like psoriasis, acne, rosacea, eczema, or UV radiation-induced inflammation, or as cosmetics to enhance skin appearance, reduce wrinkles, increase firmness, elasticity, hydration, and anti-aging effects. The HMOs can be formulated with squalane, carboxymethyl cellulose, lecithin, glyceride, etc.

Source

A composition for regulating skin microecology and repairing skin barrier that effectively inhibits Propionibacterium acnes and Staphylococcus aureus while maintaining skin health. The composition contains specific synergistic amounts of Streptococcus mitis fermentation product, α-glucan oligosaccharide, isomaltooligosaccharide, oat β-glucan, and inulin. This combination provides potent antimicrobial activity against acne-causing bacteria while preserving the skin's natural barrier function.

Source

Composition that regulates specific skin microorganisms to achieve anti-inflammatory effects through fermentation. The composition comprises lactate, sugars, and nitrogen sources as fermentation substrates, which inhibit inflammatory cytokines like IL-1β and TLR4 in the skin microbiome. The composition is engineered to selectively target and modulate skin microorganisms while maintaining a balance of beneficial microbiota, providing sustained anti-inflammatory effects.

Source

A skin care composition that promotes skin health by maintaining the natural balance of bacteria on the skin. The composition contains 1,3-propanediol as an active ingredient. It can also contain boosting ingredients like fructan and yeast extract. Applying this composition topically to the skin increases beneficial bacteria like Staphylococcus epidermidis while reducing harmful bacteria like Staphylococcus aureus. This helps maintain a healthy skin microbiome.

Source

Cosmetic composition for maintaining and restoring skin flora balance. It contains a combination of oligosaccharides and polysaccharides like inulin, fructooligosaccharides, glucooligosaccharides, and mannose monosaccharides. This composition reduces skin bacteria load and diversity after external attacks. It also prevents and treats dry, rough, and sensitive skin. The oligosaccharides and polysaccharides are prebiotics that selectively feed beneficial skin bacteria to maintain a healthy flora.

Source

Balancing the skin microbiota through a cosmetic composition that incorporates short-chain fructo-oligosaccharides and native starches. The composition, comprising a cosmetically acceptable carrier, contains at least one short-chain fructo-oligosaccharide and at least one native starch. The short-chain fructo-oligosaccharide is derived from sugar beet and has a degree of polymerization of 3, while the native starch is derived from corn and is a product of enzymatic hydrolysis. The composition is used to restore skin microbiota balance, particularly in cases of dysbiosis, by promoting beneficial bacterial growth and reducing pathogenic species.

Source

Using specific fatty acids and compositions containing them to promote a healthy skin microbiome. The fatty acids, like C18 to C24, are applied to skin to selectively support growth of beneficial commensal bacteria like Staphylococcus epidermidis and Staphylococcus hominis. This helps maintain a balanced microbiome to protect against harmful bacteria. The fatty acids can be used alone or in personal care products at concentrations up to 10% to enhance commensal bacterial growth.

Source

Composition for improving skin microbiota containing monopalmitin or its derivatives to selectively promote beneficial bacteria growth while inhibiting harmful bacteria growth. The composition selectively inhibits the growth of harmful bacteria while activating beneficial bacteria growth, particularly targeting Staphylococcus aureus and Staphylococcus epidermidis.

Source

Skin care composition with low osmolality that preserves skin microbiome stability. The composition has an osmolality of 4000 mOsm/kg water or less, comprising reduced amounts of solutes like NaCl, KCl, CaCl2, and MgCl2, and contains lactate as a carbon source. This formulation maintains skin microbiome balance while minimizing osmotic stress, making it suitable for therapeutic and cosmetic applications.

Source

A skin microecological supplement composition to improve skin health by balancing the skin microbiome. The composition contains extracts from rhodiola rosea, snow lotus, white birch sap, and aloe vera fermented with yeast, along with a microbial lysate. The fermented extracts provide nutrients and the lysate contains live bacteria. This combination aims to enhance skin barrier function, reduce inflammation, and promote skin repair by restoring the skin microbiome balance.

Source

Synchronic and bacterial-specific treatments for acne that reduces the risk of inflammation. The treatment includes using human specific species of bacteria that are modified to enhance one or more characteristics deemed beneficial to the skin microbiome and health of the individual, including bacteria that have been modified via a CRISPR-Cas9 and/or Cpf1 system to either repress the expression of a particular protein or lipid, or to increase the production of beneficial microbial secretions.

Source

Cosmetic composition that maintains or promotes beneficial skin microbiome without inhibiting beneficial bacteria growth. The composition comprises surfactant and oil, with the surfactant being a nonionic surfactant that does not inhibit beneficial bacteria growth. The composition is prepared by dissolving the surfactant in purified water, adding oil, and mixing to prepare a stable emulsion. This composition maintains beneficial bacteria populations without the need for prebiotics or probiotics, making it a novel approach to microbiome cosmetics.

Source

A method and system for enhancing the skin microbiome through targeted skin contact formulations containing beneficial bacteria and other microbe components. The method involves administering a specific skin formulation containing beneficial bacteria and other microbe components to a newborn's skin, specifically within the first 6 hours of birth. This targeted approach enables the establishment of a healthy skin microbiome through early exposure to beneficial microorganisms, which is critical for immune system development and preventing skin diseases. The formulation is specifically designed to address particular skin concerns, such as acne, and can be administered through various delivery methods, including lotions, ointments, and sprays.

Source

A skin care composition that promotes skin microbiome balance through growth-enhancing compounds. The composition comprises a carbon source, such as pyruvic acid, pyruvate, lactic acid, lactate, or a combination thereof, along with a nitrogen source like urea or arginine, and a lipid source like caprylic/capric triglycerides. These components are combined in a skin care formulation that supports the growth of beneficial skin microorganisms, maintaining a healthy skin microbiome balance.

Source

Chlamydomonas nivalis oligosaccharides that regulate skin microecology, obtained through biological fermentation technology, with potent anti-inflammatory and antimicrobial effects. These oligosaccharides inhibit harmful bacteria, modulate the skin barrier, and promote autophagy, making them suitable for cosmetic applications to soothe skin inflammation and restore skin health.

Source

Composition for promoting beneficial skin bacteria or suppressing harmful skin bacteria through the modulation of the skin microbiome. The composition contains an active ingredient that is excellent in promoting beneficial skin bacteria or suppressing harmful skin bacteria, and it was developed to significantly improve the effectiveness of promoting beneficial skin bacteria or suppressing harmful skin bacteria.

Source

Composition for enhancing beneficial skin bacteria or inhibiting harmful skin bacteria to regulate skin microbiome. The composition contains a skin-resident beneficial bacteria, such as Staphylococcus epidermidis, that promotes skin health by regulating the immune system and skin barrier function. The composition can be used to enhance beneficial skin bacteria or inhibit harmful skin bacteria, including Staphylococcus aureus, and to regulate beneficial skin bacteria and inhibit harmful skin bacteria.

Source

Compositions containing human-isolated or synthetic probiotic bacteria strains like Alcaligenes faecalis, Bacillus alcaligenes, Bacillus pumilus, Bacillus subtilis, and Bacillus indigo, and their metabolites, cell lysates, and postbiotics for treating, inhibiting, and preventing skin disorders caused by pathogenic microbes. The probiotics are derived from healthy human skin to improve skin health and combat skin infections. The compositions can be topical applications for treating conditions associated with skin pathogens like dermatophytes, yeasts, and fungi. They can be used as pharmaceuticals, cosmetics, or oral supplements.

Source

Cosmetic composition and method for enhancing the balance of beneficial skin bacteria in the skin microbiome. The composition comprises Nordic plant extracts, specifically birch sap, meadowsweet, roseroot, and chaga, in combination with xylitol, and a carrier. The extracts promote the growth of beneficial commensal bacteria while inhibiting harmful or pathogenic bacteria, particularly Staphylococcus epidermidis and Cutibacterium acnes. The composition can be used in cosmetic formulations to create a skin microbiome that is more resilient to environmental stressors and less prone to skin conditions.

Source

Ergothioneine, a naturally occurring antioxidant, is used to improve and maintain mammalian skin health through its anti-inflammatory and antioxidant properties. The compound has been found to inhibit skin-causing microorganisms while promoting beneficial microorganisms, thereby regulating skin microbiota balance and preventing skin problems like inflammation, dryness, and aging.

Source

Composition for protecting the skin from harmful bacteria while promoting growth of beneficial skin bacteria. The composition contains specific amino acids, such as cysteine, serine, alanine, aspartic acid, tyrosine, glycine, and threonine, in optimized amounts. The selected amino acids nourish commensal skin bacteria like Staphylococcus epidermidis while inhibiting growth of harmful bacteria like E. coli and Staphylococcus aureus. Applying this composition to the skin promotes a healthy skin microbiome balance. The composition can be used in personal care products to protect the skin from unwanted bacteria without broad spectrum antimicrobials.

Source

A composition that improves skin microecology through the addition of microecological regulators, specifically breast milk oligosaccharides. The composition enhances skin microbiota balance by regulating the growth of beneficial and pathogenic microorganisms, particularly beneficial bacteria, while maintaining the skin's natural barrier function. The regulators, present in breast milk oligosaccharides, promote beneficial microflora growth while suppressing pathogenic microbial populations, thereby restoring skin health and preventing skin diseases.

Source

Composition for external application containing a mixed extract of Houttuynia cordata extract and octagonal fennel extract as an active ingredient for maintaining skin microbiome balance. The composition enhances skin immunity by increasing the expression of human-derived beta-defensin, thereby enhancing skin beneficial bacteria and controlling the balance of microorganisms in the skin that suppress harmful bacteria, thereby balancing the skin microbiome.

Source

A method for enhancing skin microbiome health through targeted application of beneficial bacteria to newborn skin. The method involves administering a specific bacterial formulation to newborn skin within the first 6 hours of birth, specifically targeting beneficial bacteria like Propionibacterium acnes and Lactobacillus species. The formulation is designed to establish immune tolerance to commensal skin flora, preventing the development of skin infections and promoting a balanced skin microbiome. The approach leverages CRISPR-Cas9 and Cpf1 gene editing to modify beneficial skin bacteria, providing a novel, non-antibiotic approach to skin health.

Source

Lipopeptide sodium subtilisin for regulating skin flora distribution, particularly in maintaining skin barrier function and preventing skin infections. The lipopeptide sodium subtilisin is a naturally occurring surfactant produced by Bacillus subtilis, exhibiting potent antimicrobial activity against both pathogenic and beneficial skin bacteria. It selectively inhibits the survival of pathogenic bacteria while maintaining the viability of beneficial skin flora, thereby preserving the skin barrier and promoting wound healing.

Source

Cosmetic and therapeutic formulations containing genetically modified bacteria that can ameliorate the harmful effects of pathogenic bacteria while enhancing the skin's natural microbiome. The formulations contain a genetically engineered strain of Cutibacterium acnes with growth arrest capabilities, combined with an anhydrous formulation of the bacteria in an inactive state. The formulation maintains the growth-arrested bacteria for at least six months and up to two years, while maintaining a balance of beneficial and pathogenic microorganisms in the skin.

Source

Skin prebiotics that can be used for in vitro growth of Escherichia coli, staphylocus aureus, trichophyton mentagrophytes and Candida albicans, micrococcus lactis, neurospora alternata and Aspergillus fumigatus, and has effects of promoting the growth of probiotics on the surface of skin and inhibiting and controlling germs, and has a wide application prospect in related products such as skin prebiotics and the like. The skin prebiotics is prepared by fermenting lactobacillus lysate and a cubilose extract by using a yeast schizolysis agent and separating and purifying the fermentation product.

Source

Composition for improving skin microbiome by selectively inhibiting harmful bacteria while promoting beneficial bacteria growth. The composition contains watercress extract, which contains bioactive compounds that inhibit the growth of skin pathogenic bacteria while promoting the growth of beneficial skin flora. This composition can be used in cosmetic formulations to create a balanced skin microbiome that prevents skin diseases.

Source

A composition that selectively promotes beneficial skin bacteria while inhibiting harmful bacteria, enhancing skin microbiome balance. The composition comprises a citron extract, which is obtained through solvent extraction of citron peel, and is used to modulate the skin microbiome. The citron extract selectively inhibits pathogenic bacteria while promoting beneficial bacteria growth, thereby improving skin health and preventing disease.

Source

Composition for improving skin microbiome comprising a sandalwood extract as an active ingredient. The composition comprises a sandalwood extract as an active ingredient.

Source

Composition for improving skin microbiome by selectively inhibiting harmful bacteria while promoting beneficial bacteria growth. The composition utilizes an extract from the skin of the P. moss plant, which contains compounds that inhibit the growth of skin pathogenic bacteria while promoting the growth of beneficial skin bacteria. The extract can be used in cosmetic formulations to enhance skin microbiome balance and prevent skin diseases.

Source

Composition for improving skin microbiome comprising Daesan extract, which selectively suppresses harmful bacteria growth while promoting beneficial bacteria growth. The Daesan extract contains Daesan, a traditional Korean medicinal herb, and is used to enhance beneficial skin bacteria while inhibiting pathogenic bacteria growth. The composition can be formulated into various cosmetic products, including cleansers, moisturizers, and serums, to promote skin health through targeted microbiome balance.

Source

A skin prebiotic extract derived from honeysuckle contains acylated apigenin-7-O-glucoside, quercetin-3-O-glucopyranose, and other bioactive compounds. The extract is prepared through a combination of enzymatic modification and solvent extraction, resulting in a potent prebiotic that supports skin health by modulating the skin microbiome.

Source

Galacto-oligosaccharides support the growth of beneficial commensal Streptococcus species in the human cutaneous microbiome, particularly in infants. The galacto-oligosaccharides, particularly those from the salivarius group, are used in topical skin care compositions to promote the growth of Streptococcus thermophilus, a lactic acid bacterium that enhances ceramide production and barrier function in the skin. This composition addresses skin barrier deficiencies and inflammatory conditions in infants by supporting the natural microbiome.

Source

Using a combination of saccharide and glycerol to protect skin from harmful bacteria by nourishing commensal bacteria. The saccharide provides short-term inhibition of harmful bacteria, while glycerol provides sustained inhibition. This combination feeds commensal skin bacteria like Staphylococcus epidermidis, which produce beneficial metabolites like lactic acid that inhibit harmful bacteria. The saccharide and glycerol can be used in skin care compositions to selectively eliminate non-commensal bacteria while maintaining a healthy skin microbiome.

Source

Balancing the skin microbiota through a cosmetic composition that incorporates a specific short-chain fructo-oligosaccharide. The composition, comprising the short-chain fructo-oligosaccharide, is formulated into a cosmetic product that can be applied to the skin, body, or mucous membranes. This composition selectively promotes beneficial skin microbiota while limiting pathogenic bacteria, restoring skin microbiome diversity and promoting healthy skin conditions.

Source

Skin care composition that improves the barrier function of the skin and the distribution of microorganisms on the skin surface. The composition contains inulin/yogurt powder, rose extract, peptide, bacillus ferment, lactic acid bacterium culture lysate, and lactic acid bacterium/eriodicthione calihornicum ferment. It is a unique blend of skin-absorbable ingredients that synergistically improves skin barrier and microbiome. Adding this composition to cosmetics enhances their microbiome benefits.

Source

Composition for promoting skin microbiome balance through a synergistic blend of probiotics, antimicrobial agents, and natural stabilizers. The formulation combines rice fermented filtrate with lactobacillus fermentation product, xanthan gum, sodium benzoate, potassium sorbate, and purified water, creating a stable probiotic complex that suppresses harmful bacteria while maintaining beneficial microbial populations.

Source

Using human-derived strain of Janthinobacterium lividum bacteria, as well as its metabolites and cell lysates, to inhibit, treat, or prevent pathogenic microorganisms like fungi and bacteria. The compositions can be formulated as pharmaceuticals, cosmetics, or topical applications. The human-derived Janthinobacterium lividum provides benefits over non-human strains due to better persistence in human environments and higher metabolite production. Prebiotics can also be added to enhance probiotic growth.

Source

A dendrimer-based treatment for acne-prone skin that promotes microbiota balance and reduces inflammation. The treatment involves administering a polylysine dendrimer, specifically a G2 dendrimer, to the skin. This dendrimer selectively targets and modulates the microbiota composition in acne-prone skin, particularly by reducing the prevalence of pathogenic C. acnes strains while enhancing the populations of beneficial non-acneic strains. The treatment can be applied topically to improve skin appearance, reduce inflammation, and prevent acne lesions.

Source

A method for enhancing skin microbiome health through targeted microbial colonization. The method employs a novel formulation of beneficial skin microorganisms, specifically tailored to address skin-specific microbial imbalances, to establish a balanced skin microbiome. The formulation is administered to the skin in a specific concentration and timing, with the critical window of colonization occurring within the first 24 hours after birth. This early colonization window is critical for establishing immune tolerance to commensal skin microorganisms, preventing allergic reactions and chronic skin conditions. The formulation comprises a combination of beneficial bacteria, including Propionibacterium, Lactobacillus, and Bacteroides, that are specifically adapted to the skin environment. The formulation is delivered through a topical application, such as a lotion or ointment, and is designed to promote a healthy balance of skin microbiota, while preventing pathogenic colonization.

Source

Cosmetic composition for preventing skin irritation, allergy, and infection through the modulation of the skin microbiome. The composition comprises chitosan, a naturally occurring polysaccharide derived from chitin, which forms a protective barrier on the skin's surface. The chitosan barrier prevents pathogens from entering the skin while allowing beneficial microorganisms to colonize and thrive. The composition is delivered through a topical application, forming a physical barrier that maintains the skin's natural microbiome balance.

Source

Composition for external application to the skin containing probiotics in an active state. The composition comprises a probiotic powder, an oil phase comprising a cationic oil; and an aqueous phase comprising an anionic thickener. The probiotic powder is supported in the oil phase, where the probiotics are protected from water by encapsulating them and protecting them from aqueous phase.

Source

Composition for improving skin microbial flora comprising a ginseng extract, ginseng-derived antibacterial agent, and alkanediol. The composition enhances beneficial skin flora while inhibiting harmful bacteria through synergistic action of ginseng-derived antibacterial agent and alkanediol.

Source

A composition for treating skin disorders through the use of microbes and microbial-derived materials. The composition comprises an active drug substance comprising lyophilized coagulase-negative Staphylococcus bacteria, an inert particle, and an oil. The composition maintains long-term viability and stability during storage through the use of anhydrous excipients, specifically vegetable oils, which prevent cell membrane damage and metabolic activity. This formulation enables effective treatment of skin conditions like atopic dermatitis through targeted antimicrobial action and skin barrier modulation.

Source

A composition containing a combination of three strains of lactic acid bacteria - Lactobacillus fermentum, Lactobacillus rhamnosus, and Lactobacillus reuteri - as an active ingredient. The composition exhibits antibacterial, skin moisturizing, anti-atopic, skin barrier strengthening, and wrinkle improvement activities. The bacteria strains are isolated from the vagina of healthy women. The composition can be used for vaginitis treatment, as well as for improving skin conditions like inflammation, moisture retention, barrier function, and wrinkles.

Source

Composition for improving skin by reducing inflammation and moisturizing using a culture of specific strains of Lactobacillus lactis and Lactobacillus helveticus bacteria. The composition can be used to treat skin conditions like acne and atopic dermatitis by reducing bacterial counts of Propionibacterium acnes and Staphylococcus aureus. It also reduces inflammation markers like IL-8 and improves hyaluronan content for moisturization. The composition can be in liquid, powder, or emulsion form. The strains are Lactococcus lactis HY449 (accession KFCC-10842) and Lactobacillus helveticus HY7801 (accession KCTC 11315BP).

Source

Composition for improving skin microbiome balance and acne comprising extract of Centella asiatica grown using desalted lava seawater. The composition reduces harmful skin bacteria like Cutibacterium acnes and Staphylococcus aureus while promoting beneficial bacteria. It improves skin microbiome balance to prevent acne and inflammation. The Centella asiatica extract can be used in cosmetics, health supplements, and food products to improve skin health by balancing the skin microbiome.

Source

Composition for maintaining skin microbiome balance through synergistic action of Spiraea extract, Lactobacillus/rye flour fermentation filtrate, and European plum seed extract. The composition regulates skin microecological balance by promoting beneficial bacterial growth while inhibiting harmful bacteria, improving skin barrier function, and enhancing skin hydration.

Source