Botulinum Toxin for Facial Rhytide Management

Using a short-acting botulinum neurotoxin called BoNT/E for treating disorders like spasticity or cosmetic applications where the effect duration is shorter than traditional botulinum toxins like BoNT/A. BoNT/E provides rapid onset of neurotransmitter inhibition, gradual recovery, and shorter duration compared to BoNT/A. Doses of 0.04-5 ng BoNT/E provide effects like ≤13 days maximal inhibition, followed by >25% recovery by day 14.

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Using high doses of botulinum toxin to treat facial wrinkles, particularly glabellar frown lines, by injecting a concentrated botulinum toxin solution in small volumes. The dosage is 50-200 U and the volume is 0.05-0.35 ml. This provides a longer duration of effect without compromising safety compared to standard doses and volumes.

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Using rapid-acting botulinum toxin, like type E, for cosmetic treatments like frown line reduction, scar prevention, and wound healing. The fast-acting neurotoxin is administered prior to procedures, concurrently, or after to minimize muscle tension and prevent scarring. The dosage is low, like 0.3-19 ng, and delivered via subcutaneous injection. The fast-acting neurotoxin can be used in combination with other cosmetic procedures like fillers and lifts.

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Treating skin disorders like acne, eczema, psoriasis, rosacea, seborrhea, and wrinkles by injecting botulinum neurotoxin into nerve ganglia. The technique involves applying a therapeutically effective amount of botulinum neurotoxin to nerve ganglia, such as the sphenopalatine ganglia, to treat skin disorders and diseases. It reduces skin inflammation, pore size, and wrinkles by targeting nerve ganglia involved in skin physiology. The botulinum neurotoxin blocks neural signaling to prevent excessive skin responses. Injecting botulinum neurotoxin into nerve ganglia like the sphenopalatine ganglia can also treat skin infections related to excessive holocrine secretions.

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Injectable botulinum toxin formulation for treating wrinkles that provides higher response rates and longer duration of effect compared to current botulinum toxin products like BOTOX. The formulation contains purified botulinum toxin type A without accessory proteins, covalently linked to positively charged polylysine chains. This modified toxin composition is injected into wrinkle areas to reduce wrinkles. It achieves higher response rates and longer duration of effect compared to standard botulinum toxin products. The formulation also reduces diffusion and systemic spread compared to standard botulinum toxin products containing albumin and accessory proteins.

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Redermaneurolifting, a medical cosmetic procedure that combines botulinum toxin and high molecular weight hyaluronic acid to rejuvenate areas with thin skin. The procedure aims to reduce wrinkles and prevent aging in areas like the neck, décolleté, forehead, and around the eyes and lips. Botulinum toxin relaxes muscle tension that contributes to wrinkles, while hyaluronic acid fills the skin to reduce wrinkle depth. It is intended as an alternative to longer, more invasive procedures for thin skin areas that are less receptive to typical anti-aging treatments.

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Neuromesolifting, a combined procedure for cosmetic enhancement that involves injecting a mix of botulinum toxin and mesotherapy agents into the skin. The procedure aims to correct age-related skin issues like wrinkles, sagging, dullness, and hyperpigmentation. Botulinum toxin is injected in diluted form into the skin using the intradermal technique, along with mesotherapy cocktails containing vitamins, amino acids, antioxidants, and minerals. This combination aims to tighten skin, improve circulation, balance sebum production, and stimulate collagen synthesis.

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Injectable botulinum toxin formulations for therapeutic, aesthetic, and cosmetic uses that reduce side effects like spread and antigenicity compared to conventional botulinum toxin injections. The formulations contain botulinum toxin, a botulinum toxin complex, or a reduced botulinum toxin complex with a positively charged carrier. The carrier enhances tissue penetration and stabilization of the toxin. The formulations are injected to provide muscle paralysis, reduce spasms, treat conditions, etc.

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A composition for treating skin wrinkles, improving aging, and neuromuscular disorders by combining fillers and botulinum toxin injections. The composition uses a filler to lift and fill wrinkles, and a botulinum toxin to paralyze muscles and prevent wrinkle formation. By combining both treatments in one injection, it reduces the number of injections needed, improves convenience, and potentially enhances effects. The filler delays absorption since muscle movement promotes filler breakdown. The botulinum toxin prolongs duration since the filler gradually releases it.

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Stable nanoparticle compositions containing botulinum toxin for delivering the toxin transdermally without injection. The compositions are prepared by subjecting a premix to high shear forces to generate uniform nanoparticles. This allows botulinum toxin to penetrate skin without irritation or erosion. The nanoparticles protect the toxin from degradation and provide improved stability compared to free toxin solutions. The compositions have applications in cosmetic wrinkle reduction, hyperhidrosis treatment, and muscle contracture relief without needles.

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Topical delivery of botulinum toxin for therapeutic, aesthetic, and cosmetic purposes by using a carrier with positively charged groups to enhance transdermal transport. The carrier has a polymeric backbone with attached positively charged branching groups like lysine or arginine. The botulinum toxin associates non-covalently with the carrier for transdermal delivery. The carrier can be a peptide or polymer like PEI. The carrier prevents aggregation and enhances transdermal transport compared to using just the botulinum toxin alone. This allows topical application of botulinum toxin for treatments like muscle paralysis, pain relief, and cosmetic effects without injection.

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An improved technique for facial rejuvenation using Botulinum toxin injections that takes into account individual anatomical and physiological features of the face. The technique involves customizing Botox dosages and injection sites based on factors like bone structure, muscle size, and facial expression patterns. This personalized approach aims to maximize effectiveness and minimize side effects compared to standardized Botox regimens.

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Transdermal delivery of botulinum toxin for therapeutic, aesthetic, and cosmetic purposes using a carrier with positively charged branching groups that non-covalently binds to the botulinum toxin. The carrier enhances transdermal transport of the botulinum toxin when applied topically instead of injecting it. The carrier has a polymeric backbone with attached positively charged groups like arginine that bind to the negatively charged botulinum toxin. This allows targeted transdermal delivery of the botulinum toxin through the skin barrier.

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Enhanced botulinum toxin drug for wrinkle reduction and lifting that also has lipolytic (fat-burning) activity. The drug contains botulinum toxin type A, aminophylline, L-carnitine, and dexamethasone. When injected into facial muscles, it improves wrinkles and lifts like regular botox, but also reduces fat in the treated area due to the lipolytic components. This provides additional benefits beyond just wrinkle reduction.

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A composition for treating skin wrinkles, aging, and neuromuscular diseases using a combination of fillers and botulinum toxin. The composition comprises a filler like hyaluronic acid to temporarily lift and fill wrinkles, and botulinum toxin like Botox to paralyze muscles and prevent wrinkle formation. The filler and Botox are mixed in varying ratios for improved effectiveness and reduced injections compared to using them separately. The filler prolongs Botox action as it slows muscle movement, and Botox reduces filler absorption as it paralyzes muscles. The combination synergistically enhances anti-wrinkle and anti-aging effects with fewer treatments.

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Prolonging the anti-aging effects of botulinum toxin injections by administering peptides derived from SNAP-25 protein and/or enkephalin to the skin. The peptides block neuronal exocytosis and when used in combination with botulinum toxin injections, reduce wrinkles and delay the need for repeat botulinum toxin treatments. The peptides can be formulated into cosmetic or pharmaceutical compositions for topical application to the skin.

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Nanoemulsion compositions containing botulinum toxin for cosmetic and medical applications. The compositions are made by microfluidization to create nanoparticles with botulinum toxin encapsulated inside or adsorbed on the surface. The nanoemulsion allows transdermal delivery of botulinum toxin without skin irritation or abrasion. It can be used to smooth wrinkles, treat hyperhidrosis, reduce muscle contracture, and improve conditions like hyperactivity. The nanoemulsion particles have sizes below 120 nm, with the majority around 90 nm.

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A method for treating skin conditions like wrinkles, laxity, texture, tone, and color irregularities using a botulinum toxin like Botox. The method involves applying small punctures to the skin and then injecting diluted botulinum toxin into the puncture sites. This allows the botulinum toxin to be absorbed into the skin instead of injecting it directly. The punctures are made until the skin bleeds, erythema, and edema are visible, and then the botulinum toxin is applied and absorbed. This is repeated multiple times to treat the area. The puncture and absorption method allows the botulinum toxin to be distributed more evenly in the skin compared to direct injection.

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Topical botulinum toxin compositions for skin applications like cosmetics and therapy that have improved safety and efficacy compared to injectable forms. The compositions contain reduced amounts of native proteins in botulinum toxin complexes, like hemagglutinin and albumin, to decrease toxicity and improve penetration through skin epithelium. Adhesion molecules that bind to botulinum toxin are added to further enhance skin adherence and penetration. This allows topical application of botulinum toxin for treating conditions like wrinkles, sweating, pain, acne, and immune response without requiring injection.

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Topical delivery of botulinum toxin for treating wrinkles, hyperhidrosis, and other conditions by applying a composition containing the toxin and a positively charged carrier to the skin. The carrier forms a non-covalent complex with the toxin to facilitate transdermal transport. The positively charged carrier can be a polypeptide or polymer with branching groups. Adding oligocrosslinks or polyanionic crosslinks further improves complex formation.

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