Transdermal Delivery Systems for Anti-Aging Compositions

Composition for enhancing transdermal absorption of topical cosmetics like creams, lotions, and serums. The composition contains a morpholine derivative like N-dodecyl morpholine, N-decyl morpholine, or N-tetradecyl-2-methoxy-6-hydroxymethylmorpholine, along with a transdermal absorption enhancer like laurocapram, sodium lauryl sulfate, or urea. The morpholine derivative helps fluidize the lipid layers of the skin barrier, while the enhancer further alters the barrier properties to improve absorption of active ingredients like collagen and hyaluronic acid.

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Moisturizing and anti-aging liposome emulsion for skin care that provides both hydration and anti-aging benefits. The emulsion contains ingredients like phosphatidylcholine, pomegranate sterols, grape seed oil, white pond flower seed oil, amino acid moisturizers, tocopherol, glycerin, butylene glycol, polydimethylsiloxane, evening primrose extract, red wine extract, glycolipid, olive fruit extract, European water sprout extract, acrylic acid copolymer, arginine, ergothioneine, nicotinamide mononucleotide, Sphingomonas extract, hyaluronic acid, EDTA, pentaerythritol tetrakis ester, fragrance, preservative, and water. The liposome

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Flexible liposomes containing highly delivered Centella asiatica extract and madecassic acid, which are encapsulated in a lipid matrix. The liposomes are prepared through a novel method that enables efficient delivery of these active ingredients through the skin barrier. The liposomes contain a blend of polyol, liquid lipid, phospholipid, emulsifier, and the active ingredients, with a specific ratio of ingredients that balances delivery efficiency and skin penetration. The liposomes are designed to maintain their structure and integrity during storage and use, ensuring sustained delivery of the active ingredients.

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Microneedle patches that deliver dual therapeutic effects through controlled transdermal delivery of natural compounds. The microneedles contain a matrix of chitosan, which slowly releases dihydromyricetin and hesperetin, a pair of natural polyphenols derived from traditional Chinese medicine. These compounds inhibit melanin production and prevent glycation, respectively, providing comprehensive anti-aging and whitening benefits. The microneedle patches can be used for sustained release of these natural compounds, offering a minimally invasive and painless delivery system for skin care products.

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Carrier composition for transdermal delivery of active substances that enables enhanced skin penetration through pH-dependent particle size changes. The composition comprises hyaluronic acid nanoparticles that exhibit pH-dependent particle size reduction, allowing them to form stable, controlled delivery systems. By maintaining a stable formulation even at high temperatures, the composition ensures consistent delivery of active substances through transdermal absorption. The pH-sensitive hyaluronic acid particles can be engineered to release their active substance in response to skin pH, facilitating targeted delivery.

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Retinol encapsulation for skin care products that addresses the challenges of retinol stability and skin irritation. The encapsulation method involves using a surfactant like Solulan 16 to stabilize retinol, which is then encapsulated in liposomes. The encapsulation process involves high-pressure homogenization to create stable liposomes that retain retinol's anti-aging benefits while minimizing skin irritation. The encapsulation method enables controlled release of retinol, improving skin penetration and efficacy.

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Double-layer lipid microsphere emulsion for targeted transdermal delivery of skin care actives. The emulsion has an outer layer of large lipid microsphere vesicles that penetrate the stratum corneum and granular layer, and an inner layer of nanolipid microsphere vesicles. The large vesicles carry water-based actives to the spinous layer, where they release the nanolipid microsphere cargo of oily actives. This allows both oil and water soluble actives to reach the deeper epidermis layers. The double-layer structure prevents premature release in the outer layers.

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Liposomes that enhance skin absorption and efficacy through enhanced adhesion and improved penetration. The liposomes contain collagen with an optimal content that optimizes skin penetration of skin active ingredients, including collagen, while maintaining skin adhesion. This formulation enables more effective delivery of skin rejuvenating agents to the skin surface, thereby improving skin texture and appearance.

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Supramolecular lipid vesicles containing retinol derivatives for stable, low irritant, and effective topical skincare products. The vesicles are prepared by dissolving retinol derivatives like hydroxypinacolone retinoate and retinol propionate in supramolecular solvents along with degradable polymers, phospholipids, emulsifiers, and oils. The vesicles provide stabilized, controlled release of the retinol derivatives for anti-aging benefits with reduced irritation compared to free retinol.

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Anti-aging composition containing retinyl palmitate with enhanced stability and transdermal delivery. The composition comprises retinyl palmitate, aminobutyric acid, and arginine/lysine peptides, formulated with a combination of emulsifiers and solvents to achieve superior skin penetration and efficacy. The formulation is particularly effective in cosmetics formulations, particularly in creams, lotions, and gels, where skin penetration is critical.

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Lipid vesicles for intradermal delivery of anionic polymeric materials, such as hyaluronic acid, that enable below-surface skin penetration. The vesicles contain an anionic polymeric material encapsulated within a lipid bilayer, with an entrapped oil-in-water emulsion. This unique composition allows the anionic polymeric material to distribute below the skin surface while maintaining its beneficial skin properties.

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A water-soluble ceramide nano-microemulsion composition and its preparation method for enhancing skin hydration and barrier function. The composition comprises ceramide 2 and ceramide 3, encapsulated in a nano-microemulsion matrix formed by a combination of surfactants and polyols. The emulsion maintains its water-oil balance and enhances skin protection while promoting epidermal hydration and cell regeneration. The nano-microemulsion has a unique particle size and morphology that enables effective skin penetration and stability.

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A liposome-based anti-aging treatment that enhances skin elasticity and reduces wrinkles through targeted delivery of natural ingredients. The composition utilizes liposomes to encapsulate sturgeon caviar extract, Terminalia fadifolia extract, and wild soybean peptide, which are combined in a phosphate buffer solution at a concentration of 10 mg/mL. The liposomes are prepared using a membrane material that selectively dissolves in ethanol, allowing the encapsulated active ingredients to penetrate the skin barrier. The liposomes deliver these natural ingredients to the dermis, where they exert their anti-aging effects through enhanced absorption and tissue repair. The composition demonstrates improved penetration and efficacy compared to conventional anti-aging treatments.

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Green natural supramolecular liposome emulsion for skin care products that combines the benefits of natural emulsifiers and supramolecular stabilization with the advantages of supramolecular liposomes. The emulsion comprises a water-soluble phase and an oil-soluble phase, with natural emulsifiers and supramolecular materials incorporated into the oil phase. This formulation enables effective delivery of active ingredients through the skin barrier while maintaining skin health and preventing irritation. The emulsion is prepared through a simple and environmentally friendly process that replaces traditional emulsifiers with natural components.

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A liposome composition encapsulating oligopeptides for improved skin care and repair. The liposome composition contains oligopeptides like collagen and umbilical cord extract, tocopherol, ceramide, lecithin, and distilled water. The oligopeptides are encapsulated using a layered protection technique. First, tocopherol is wrapped around oligopeptide-1 to prevent water deactivation. Then ceramide and lecithin surround the tocopherol layer. This protects the oligopeptides from water contact during preparation. The layered encapsulation minimizes oligopeptide inactivation and enhances biological activity. The liposome composition is applied to skin for repair and anti-aging benefits.

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A dermal elasticity improving agent that promotes the production of LTBP2 and/or fibrillin 1, thereby increasing and/or stabilizing the dermal papillary layer fibers. The agent contains 1-(2-hydroxyethyl)-2-imidazolidinone or its derivatives as an active ingredient. These compounds enhance the expression of LTBP2 and/or fibrillin 1 in fibroblasts, leading to increased dermal papillary fiber growth and stabilization. This agent can be used in non-therapeutic cosmetic formulations to improve skin elasticity and wrinkle appearance.

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A nanostructured DHA-based anti-aging and anti-inflammatory agent that enhances skin penetration and efficacy through a novel encapsulation method. The nano-encapsulated DHA, combined with natural antioxidants like ergothioneine and bosine, is stabilized by a surfactant blend of phospholipids, cholesterol, and polyhydric alcohols. The formulation achieves improved skin penetration through its unique phospholipid bilayer structure, which closely mimics the skin's natural barrier function. The nano-encapsulated DHA formulation demonstrates enhanced anti-aging and anti-inflammatory effects compared to traditional DHA formulations, with superior skin penetration and bioavailability.

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Skin barrier repair and cell repair anti-wrinkle composition for cosmetics that combines ingredients to simultaneously repair skin barrier function and promote cell repair. The composition contains surfactants, skin conditioners, fatty acids, fatty alcohols, antioxidants, humectants, ceramides, phospholipids, flaxseed extract, medicinal sage extract, and grape flower extract. The ingredients are mixed in specific ratios to form a stable liposome structure that repairs damaged skin cells, stimulates ceramide production, accelerates metabolism, and differentiates basal layer cells.

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Formulations for topical delivery of active agents that enhance skin penetration while maintaining high saturation of the active ingredient and diffusion coefficient enhancer. The formulations incorporate a co-enhancer active ingredient delivery system with the aesthetics of cosmetic and cosmeceutical technology. The system includes a cosmetic active agent, a skin barrier repair combination, and a partition coefficient enhancer with a diffusion coefficient enhancer. The formulation utilizes a hydrocarbon-based silicone emollient excipient that maintains high saturation of both the active ingredient and diffusion coefficient enhancer, ensuring optimal skin penetration while preventing adverse effects typically associated with emollients.

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A face cream composition containing liposomes with anti-aging benefits. The liposomes contain specific active ingredients like hexapeptide-11, Dunaliella salina extract, Fletcher's willow leaf extract, and Gynostemma pentaphyllum extract. These ingredients when encapsulated in liposomes enhance their transdermal delivery and residence time in the skin. This allows slow release and increased utilization of the active ingredients to combat skin aging and relaxation. The cream also contains other ingredients like hyaluronic acid, xylitol, trehalose, and isohexadecane.

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