Transdermal Delivery Systems for Anti-Aging Compositions

Composition for enhancing transdermal absorption of topical cosmetics like creams, lotions, and serums. The composition contains a morpholine derivative like N-dodecyl morpholine, N-decyl morpholine, or N-tetradecyl-2-methoxy-6-hydroxymethylmorpholine, along with a transdermal absorption enhancer like laurocapram, sodium lauryl sulfate, or urea. The morpholine derivative helps fluidize the lipid layers of the skin barrier, while the enhancer further alters the barrier properties to improve absorption of active ingredients like collagen and hyaluronic acid.

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Moisturizing and anti-aging liposome emulsion for skin care that provides both hydration and anti-aging benefits. The emulsion contains ingredients like phosphatidylcholine, pomegranate sterols, grape seed oil, white pond flower seed oil, amino acid moisturizers, tocopherol, glycerin, butylene glycol, polydimethylsiloxane, evening primrose extract, red wine extract, glycolipid, olive fruit extract, European water sprout extract, acrylic acid copolymer, arginine, ergothioneine, nicotinamide mononucleotide, Sphingomonas extract, hyaluronic acid, EDTA, pentaerythritol tetrakis ester, fragrance, preservative, and water. The liposome

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Flexible liposomes containing highly delivered Centella asiatica extract and madecassic acid, which are encapsulated in a lipid matrix. The liposomes are prepared through a novel method that enables efficient delivery of these active ingredients through the skin barrier. The liposomes contain a blend of polyol, liquid lipid, phospholipid, emulsifier, and the active ingredients, with a specific ratio of ingredients that balances delivery efficiency and skin penetration. The liposomes are designed to maintain their structure and integrity during storage and use, ensuring sustained delivery of the active ingredients.

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Microneedle patches that deliver dual therapeutic effects through controlled transdermal delivery of natural compounds. The microneedles contain a matrix of chitosan, which slowly releases dihydromyricetin and hesperetin, a pair of natural polyphenols derived from traditional Chinese medicine. These compounds inhibit melanin production and prevent glycation, respectively, providing comprehensive anti-aging and whitening benefits. The microneedle patches can be used for sustained release of these natural compounds, offering a minimally invasive and painless delivery system for skin care products.

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Carrier composition for transdermal delivery of active substances that enables enhanced skin penetration through pH-dependent particle size changes. The composition comprises hyaluronic acid nanoparticles that exhibit pH-dependent particle size reduction, allowing them to form stable, controlled delivery systems. By maintaining a stable formulation even at high temperatures, the composition ensures consistent delivery of active substances through transdermal absorption. The pH-sensitive hyaluronic acid particles can be engineered to release their active substance in response to skin pH, facilitating targeted delivery.

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Retinol encapsulation for skin care products that addresses the challenges of retinol stability and skin irritation. The encapsulation method involves using a surfactant like Solulan 16 to stabilize retinol, which is then encapsulated in liposomes. The encapsulation process involves high-pressure homogenization to create stable liposomes that retain retinol's anti-aging benefits while minimizing skin irritation. The encapsulation method enables controlled release of retinol, improving skin penetration and efficacy.

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Double-layer lipid microsphere emulsion for targeted transdermal delivery of skin care actives. The emulsion has an outer layer of large lipid microsphere vesicles that penetrate the stratum corneum and granular layer, and an inner layer of nanolipid microsphere vesicles. The large vesicles carry water-based actives to the spinous layer, where they release the nanolipid microsphere cargo of oily actives. This allows both oil and water soluble actives to reach the deeper epidermis layers. The double-layer structure prevents premature release in the outer layers.

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Liposomes that enhance skin absorption and efficacy through enhanced adhesion and improved penetration. The liposomes contain collagen with an optimal content that optimizes skin penetration of skin active ingredients, including collagen, while maintaining skin adhesion. This formulation enables more effective delivery of skin rejuvenating agents to the skin surface, thereby improving skin texture and appearance.

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Supramolecular lipid vesicles containing retinol derivatives for stable, low irritant, and effective topical skincare products. The vesicles are prepared by dissolving retinol derivatives like hydroxypinacolone retinoate and retinol propionate in supramolecular solvents along with degradable polymers, phospholipids, emulsifiers, and oils. The vesicles provide stabilized, controlled release of the retinol derivatives for anti-aging benefits with reduced irritation compared to free retinol.

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Anti-aging composition containing retinyl palmitate with enhanced stability and transdermal delivery. The composition comprises retinyl palmitate, aminobutyric acid, and arginine/lysine peptides, formulated with a combination of emulsifiers and solvents to achieve superior skin penetration and efficacy. The formulation is particularly effective in cosmetics formulations, particularly in creams, lotions, and gels, where skin penetration is critical.

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Lipid vesicles for intradermal delivery of anionic polymeric materials, such as hyaluronic acid, that enable below-surface skin penetration. The vesicles contain an anionic polymeric material encapsulated within a lipid bilayer, with an entrapped oil-in-water emulsion. This unique composition allows the anionic polymeric material to distribute below the skin surface while maintaining its beneficial skin properties.

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A water-soluble ceramide nano-microemulsion composition and its preparation method for enhancing skin hydration and barrier function. The composition comprises ceramide 2 and ceramide 3, encapsulated in a nano-microemulsion matrix formed by a combination of surfactants and polyols. The emulsion maintains its water-oil balance and enhances skin protection while promoting epidermal hydration and cell regeneration. The nano-microemulsion has a unique particle size and morphology that enables effective skin penetration and stability.

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A liposome-based anti-aging treatment that enhances skin elasticity and reduces wrinkles through targeted delivery of natural ingredients. The composition utilizes liposomes to encapsulate sturgeon caviar extract, Terminalia fadifolia extract, and wild soybean peptide, which are combined in a phosphate buffer solution at a concentration of 10 mg/mL. The liposomes are prepared using a membrane material that selectively dissolves in ethanol, allowing the encapsulated active ingredients to penetrate the skin barrier. The liposomes deliver these natural ingredients to the dermis, where they exert their anti-aging effects through enhanced absorption and tissue repair. The composition demonstrates improved penetration and efficacy compared to conventional anti-aging treatments.

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Green natural supramolecular liposome emulsion for skin care products that combines the benefits of natural emulsifiers and supramolecular stabilization with the advantages of supramolecular liposomes. The emulsion comprises a water-soluble phase and an oil-soluble phase, with natural emulsifiers and supramolecular materials incorporated into the oil phase. This formulation enables effective delivery of active ingredients through the skin barrier while maintaining skin health and preventing irritation. The emulsion is prepared through a simple and environmentally friendly process that replaces traditional emulsifiers with natural components.

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A liposome composition encapsulating oligopeptides for improved skin care and repair. The liposome composition contains oligopeptides like collagen and umbilical cord extract, tocopherol, ceramide, lecithin, and distilled water. The oligopeptides are encapsulated using a layered protection technique. First, tocopherol is wrapped around oligopeptide-1 to prevent water deactivation. Then ceramide and lecithin surround the tocopherol layer. This protects the oligopeptides from water contact during preparation. The layered encapsulation minimizes oligopeptide inactivation and enhances biological activity. The liposome composition is applied to skin for repair and anti-aging benefits.

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A dermal elasticity improving agent that promotes the production of LTBP2 and/or fibrillin 1, thereby increasing and/or stabilizing the dermal papillary layer fibers. The agent contains 1-(2-hydroxyethyl)-2-imidazolidinone or its derivatives as an active ingredient. These compounds enhance the expression of LTBP2 and/or fibrillin 1 in fibroblasts, leading to increased dermal papillary fiber growth and stabilization. This agent can be used in non-therapeutic cosmetic formulations to improve skin elasticity and wrinkle appearance.

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A nanostructured DHA-based anti-aging and anti-inflammatory agent that enhances skin penetration and efficacy through a novel encapsulation method. The nano-encapsulated DHA, combined with natural antioxidants like ergothioneine and bosine, is stabilized by a surfactant blend of phospholipids, cholesterol, and polyhydric alcohols. The formulation achieves improved skin penetration through its unique phospholipid bilayer structure, which closely mimics the skin's natural barrier function. The nano-encapsulated DHA formulation demonstrates enhanced anti-aging and anti-inflammatory effects compared to traditional DHA formulations, with superior skin penetration and bioavailability.

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Skin barrier repair and cell repair anti-wrinkle composition for cosmetics that combines ingredients to simultaneously repair skin barrier function and promote cell repair. The composition contains surfactants, skin conditioners, fatty acids, fatty alcohols, antioxidants, humectants, ceramides, phospholipids, flaxseed extract, medicinal sage extract, and grape flower extract. The ingredients are mixed in specific ratios to form a stable liposome structure that repairs damaged skin cells, stimulates ceramide production, accelerates metabolism, and differentiates basal layer cells.

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Formulations for topical delivery of active agents that enhance skin penetration while maintaining high saturation of the active ingredient and diffusion coefficient enhancer. The formulations incorporate a co-enhancer active ingredient delivery system with the aesthetics of cosmetic and cosmeceutical technology. The system includes a cosmetic active agent, a skin barrier repair combination, and a partition coefficient enhancer with a diffusion coefficient enhancer. The formulation utilizes a hydrocarbon-based silicone emollient excipient that maintains high saturation of both the active ingredient and diffusion coefficient enhancer, ensuring optimal skin penetration while preventing adverse effects typically associated with emollients.

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A face cream composition containing liposomes with anti-aging benefits. The liposomes contain specific active ingredients like hexapeptide-11, Dunaliella salina extract, Fletcher's willow leaf extract, and Gynostemma pentaphyllum extract. These ingredients when encapsulated in liposomes enhance their transdermal delivery and residence time in the skin. This allows slow release and increased utilization of the active ingredients to combat skin aging and relaxation. The cream also contains other ingredients like hyaluronic acid, xylitol, trehalose, and isohexadecane.

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A novel anti-aging composition for skin care products that combines the benefits of soybean lecithin, glycerin, caprylic/capric triglyceride, and Dendrobium officinale stem extract to enhance collagen renewal and skin tightening. The composition achieves superior skin absorption and penetration through optimized formulation parameters, including the addition of glycerin, caprylic/capric triglyceride, and polysorbate-80. The Dendrobium officinale stem extract, derived from a traditional Chinese medicinal plant, provides additional anti-aging benefits through its unique bioactive compounds. The formulation is particularly effective in repairing skin tissue morphology and accelerating collagen fiber renewal, making it suitable for anti-aging cosmetics and skin care products.

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A hydroxy pinacolone retinoate supramolecular liposome preparation for improved cosmetic absorption and effectiveness. The liposome contains specific ratios of hydroxy pinacolone retinoate, isosorbide tincture dimethyl ether, polysorbate-60, poloxamer, sucrose laurate, and modified ceramide. The liposome is prepared by dissolving the components, mixing them, micronizing, and then nanometerizing to form the supramolecular liposome. This provides increased solubility, oil-water partitioning, and reduced skin barrier penetration resistance compared to conventional hydroxy pinacolone retinoate alone.

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A cosmetic composition that combines anti-aging and moisturizing properties with transdermal delivery capabilities. The formulation comprises a combination of ingredients including elastin, p-hydroxyacetophenone, fullerene, glycerin, glycerin glucose shake, xanthan gum, arginine, arginine/lysine peptide, soluble collagen, sodium chloride, hydroxypropyltetrahydropyrantriol, and gentian extract. The composition is formulated with a wetting agent, propylene glycol, and butylene glycol, and is designed to deliver active ingredients through the skin's dermal layer. The composition addresses skin aging by promoting collagen synthesis, improving skin elasticity, and enhancing cell vitality, while also addressing water loss through its moisturizing properties.

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Cosmetic composition for enhancing skin absorption of active ingredients through interaction with intercellular lipids in the stratum corneum. The composition comprises a nanoparticle delivery system containing a cholesterol derivative, along with ceramide, fatty acids, and hydrogenated lecithin. The delivery system forms a lamellar structure similar to skin lipids, enhances skin barrier function, and promotes absorption of bioactive substances through interaction with intercellular lipids.

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A cosmetic composition containing lipoic acid encapsulated within fullerene liposomes, which enhances skin hydration and firmness through targeted delivery of antioxidants and skin-protective agents. The composition comprises lipoic acid, fullerene liposomes, and a combination of humectants, emollients, and preservatives. The liposomes encapsulate the active ingredients in a stable, water-soluble form that penetrates deep into the skin, delivering sustained benefits through enhanced skin permeability.

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Melatonin encapsulated in flexible liposomes for transdermal delivery of the hormone, with enhanced penetration and bioavailability compared to conventional oral formulations. The liposomes contain melatonin encapsulated in a lipid bilayer with sodium deoxycholate as a surfactant, and are prepared through a film dispersion method. The liposomes exhibit improved penetration characteristics through the skin barrier, with enhanced transdermal delivery of melatonin compared to conventional liposomes. The liposomes maintain their structure and biocompatibility even after penetration through the skin, with improved skin penetration and efficacy in treating photoaging skin lesions.

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A liposomal formulation containing recombinant humanized collagen, carnosine, and carrageenan that provides anti-wrinkle and firming effects through targeted skin penetration. The formulation combines these natural ingredients with lecithin in a liposomal matrix, which enables controlled release and sustained delivery of the active ingredients to the skin. The liposomes are prepared using a deionized water process, ensuring minimal environmental impact and purity. The formulation demonstrates improved skin hydration, firmness, and wrinkle reduction compared to conventional anti-aging treatments, with a unique combination of natural, biocompatible ingredients that addresses both intrinsic and extrinsic aging factors.

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Cosmetic composition with enhanced stabilization and skin penetration of poorly soluble ingredients. The composition comprises a hydrotrope, a poorly soluble substance, and a carrier system. The hydrotrope stabilizes the poorly soluble substance, while the carrier system enhances its skin penetration. The composition contains a quantitative extract of Centella asiatica, including asiatic acid, ceramide, retinoid, coenzyme Q-10, ursolic acid, oleanolic acid, lipoic acid, etc.

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A nano-composition for repairing skin barrier function, comprising a combination of palmitoamide ethanolamine, oleoylethanolamine, and anandamide, delivered through a proprietary lipid matrix. The composition is formulated to maintain optimal delivery and repair efficacy through precise lipid composition and delivery system. The matrix is optimized for barrier repair through its precise fatty acid amide and ceramide content, while maintaining the skin's natural barrier function.

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Cosmetic composition containing nanoliposomes that improves stability and absorption of retinol and peptides for anti-aging benefits. The composition contains liposomes, co-surfactants, shea butter, alcohol, glyceryl stearate, cetostearyl alcohol, water, and other ingredients like hyaluronic acid, panthenol, trehalose, thickeners, neutralizers, antioxidants. The nanoliposomes encapsulate retinol and peptides for better solubility and absorption. The composition aims to reduce fine lines, wrinkles, and improve skin elasticity using retinol and peptides.

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A transdermal delivery system for efficiently delivering molecules through the skin using nanoparticles with a lipophilic exterior and a hydrophilic core. The particles have a diameter of 10-200 nanometers and are prepared by polymerizing a hydrophilic monomer in water while dispersing oil-soluble agents in oil. This creates particles with a hydrophilic core surrounded by lipophilic side chains that allow penetration through the lipid-rich stratum corneum layer of skin. The hydrophilic molecules in the core pass through the water channels between cells while the lipophilic exterior is compatible with the lipids in skin. This enables transdermal delivery of hydrophilic molecules like drugs and nutrients through the skin barrier.

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A method for transdermally delivering dual therapeutic and cosmetic agents through a single device. The method employs a microneedle array with a high-aspect-ratio structure that enables controlled penetration of both therapeutic and cosmetic agents into the skin. The array's precise micropillars are designed to facilitate both drug delivery and cosmetic application simultaneously, allowing the same device to be used for both therapeutic and cosmetic purposes.

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A multi-dimensional synergistic solution for skin aging treatment that combines multiple active ingredients to address oxidative stress, inflammation, pigmentation, and moisture loss. The solution comprises a transfer body gel formulation containing B-arbutin, tranexamic acid, sodium hyaluronate, allantoin, vitamin B12, and hydroxyethyl urea. The transfer body encapsulates these ingredients in a lipid vesicle matrix, utilizing the transfer body's elastic deformation to penetrate the skin barrier. The formulation combines plant extracts, vitamins, and chemical high-purity substances to synergistically address skin aging from multiple dimensions.

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Liposomal compositions containing tocopherol phosphate mixtures for improving skin health. The liposomal compositions have a pH of 4.5-5 and contain a liposome made of tocopherol phosphate derivatives, a polar solvent system, water soluble phase, and a neutralizing base. Topical formulations with these liposomal compositions can be used to improve skin appearance, reduce signs of aging, and enhance extracellular matrix proteins like decorin. The liposomes entrap lipophilic ingredients and dissolve water-soluble ones. The formulations have 0.1-40% liposomal content.

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A novel anti-aging composition and preparation method that harnesses the synergistic effects of bioactive compounds to promote dermal cell proliferation and collagen production. The composition comprises nano-liposomes encapsulating bioactive ingredients such as diglucosylglycolic acid, glucosyl hesperidin, spilanthol extract, biotin, and caffeine. The liposomes are loaded with these bioactive compounds, which work together to stimulate collagen synthesis and improve skin elasticity, while also enhancing cell proliferation and reducing fine lines and wrinkles. The composition can be formulated into various cosmetic products, including toners, masks, essences, eye creams, and moisturizers, offering a targeted and sustained anti-aging solution.

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Supramolecular liposomes encapsulating vitamin C, matrine, and ferulic acid deliver synergistic skin benefits through controlled release. The liposomes encapsulate these active ingredients in a lipophilic matrix, protecting them from environmental degradation while facilitating penetration through the skin barrier. The liposomes' aqueous core contains water-soluble ingredients like hyaluronic acid and glycerin, while the lipophilic outer layer contains the active ingredients. This dual encapsulation strategy enables sustained release of the active ingredients, enhancing their skin-whitening, anti-aging, and antiviral effects.

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An anti-aging cosmetic composition that has improved permeability and efficacy compared to traditional anti-aging products. The composition contains a vesicle material made from nonionic surfactants, which improves permeability. The vesicle material wraps other active ingredients like extracts of seaweed, acerola, and alfalfa. The combination of these ingredients has anti-aging effects like antioxidation, wrinkle reduction, and skin elasticity improvement.

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A cosmetic composition and preparation method that combines multiple anti-aging components through synergistic liposome delivery. The composition comprises anti-aging liposomes containing Bacillus licheniformis/glutamic acid fermentation filtrate, bird's nest acid, and proanthocyanidin, which form stable liposomes that encapsulate anti-aging agents. The liposomes enhance skin hydration, barrier function, and collagen production, while the encapsulated anti-aging agents deliver their anti-aging effects through targeted delivery.

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Anti-aging cosmetic composition using cationic nanoliposomes to improve the stability and efficacy of active ingredients like astaxanthin, flax lignans, bakuchiol, and retinoic acid esters for anti-aging benefits. The nanoliposomes are made by a specific preparation method involving lipids like DDCTMA and DMAPA-CHEMS, a biosugar gum-PEG copolymer, and cosolvents. The lipid ratio, composition, and polymer are optimized to encapsulate and deliver the anti-aging actives more efficiently.

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Cream composition containing liposomes that increases skin collagen density through a synergistic combination of natural ingredients. The composition comprises liposomes encapsulating bird's nest acid, myrrh leaf extract, and Pseudochlorococcum eye-shaped veins, which work together to replenish skin moisture, provide essential nutrients, prevent collagen degradation, and stabilize skin structure. The liposomes enhance skin collagen density by promoting cell metabolism, preventing elastin oxidation, and maintaining skin elasticity.

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A cream composition containing liposomes that improves skin elasticity through the delivery of bioactive ingredients. The composition comprises liposomes encapsulating bioactive ingredients like Fucus serrata extract and bird's nest acid, which are delivered through a freeze-drying process. The liposomes enhance the transdermal delivery of these bioactive ingredients, particularly in the skin's dermis, where they support collagen and elastin synthesis, inhibit glycosylation, and restore skin elasticity.

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Multifunctional liposome containing hyaluronic acid with three different molecular weights and natural extracts for skincare applications. The liposome uses hyaluronic acid with molecular weights of 2000-5000 kDa, 500-1000 kDa, and 10-500 kDa. It also contains extracts like lycium barbarum polysaccharide, yeast essence, chamomile extract, ginsenoside, and plant active polypeptide. The liposome delivers the hyaluronic acid and extracts to the skin layers for moisturization, anti-aging, whitening, antioxidant, and eye health benefits. The liposome stability is enhanced by using hyaluronic acid with different sizes.

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An anti-aging cosmetic composition containing specific ingredients like giant salamander polypeptide, Dendrobium officinale polysaccharide, tea polyphenols, hyaluronic acid, Ophiopogon japonicus polysaccharide, wolfberry polysaccharide, and grape seed oil. The composition can be encapsulated in lipid vesicles for better efficacy. The ingredients work synergistically to delay skin aging by reducing wrinkles, increasing elasticity, and improving skin texture.

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A liposome-containing anti-aging skin care matrix that improves stability and effectiveness of astaxanthin, a key anti-aging ingredient, in cosmetics. The matrix includes liposomes of astaxanthin, ceramide, collagen, and peptides. The liposome encapsulation stabilizes astaxanthin, preventing degradation. The liposomes also enhance the skin benefits of the other ingredients, like ceramide for barrier repair and peptides for collagen synthesis. The liposome-containing matrix provides a stable, potent anti-aging skin care formula.

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A skin care product containing liposomes that tightens the skin through targeted delivery of skin-rejuvenating ingredients. The product combines liposomes with skin tightening agents to deliver these benefits through transdermal absorption, enhancing skin firmness and elasticity. The liposomes encapsulate skin-rejuvenating ingredients such as peptides, hyaluronic acid, and collagen, which are delivered to the skin's dermal layer to stimulate collagen synthesis and improve skin texture. The liposomes protect the skin from environmental stressors while facilitating the absorption of these beneficial ingredients. This formulation addresses the challenges of delivering effective skin rejuvenation through topical treatments.

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A transdermal delivery system for enhanced skin penetration and therapeutic efficacy. The system utilizes a temperature-sensitive polymer as a skin barrier, with a liposome encapsulating the active ingredient. The liposome encapsulates the active ingredient in a hydrophobic environment, while the temperature-sensitive polymer maintains the liposome's integrity at body temperature. This combination enables rapid and sustained delivery of therapeutic agents through the skin, with enhanced permeation compared to traditional delivery methods.

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Anti-aging composition and method for skin rejuvenation that addresses the complex mechanisms of skin aging through targeted delivery of bioactive ingredients. The composition comprises a unique blend of okra polysaccharide and lecithin, which is formulated into a stable, water-soluble matrix. This matrix is then processed through controlled heat treatment to create a stable, bioactive delivery system. The composition is formulated to deliver specific anti-aging benefits, including the inhibition of MMPs and inflammatory cytokines, while maintaining optimal skin hydration. The composition is designed to provide sustained, long-lasting anti-aging effects through controlled transdermal absorption.

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Liposome-based compositions for delivering skin bioactive substances to improve skin health and beauty. The compositions contain liposomes made with a phospholipid and an edge activator to enhance skin penetration of hydrophilic active ingredients. The liposomes provide stable, effective delivery of skin bioactives like antioxidants, anti-aging compounds, and wrinkle fighters compared to conventional topical applications. This improves skin conditions by addressing issues like aging, damage, and wrinkles.

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A lyophilized Rhodiola rosea liposome powder for skin care that enhances transdermal delivery and bioavailability. The powder is prepared through a freeze-drying process that incorporates Rhodiola rosea liposomes into a stable emulsion with moisturizing and antioxidant properties. The liposomes facilitate localized penetration into the skin's stratum corneum, while the emulsion formulation ensures effective delivery to the dermal layers. This formulation provides improved skin care benefits compared to traditional Rhodiola extracts, particularly in enhancing skin rejuvenation and anti-aging effects.

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Composition with anti-aging and moisturizing effects that addresses skin aging through a synergistic blend of hyaluronic acid microcapsules and active liposomes. The composition combines hyaluronic acid microcapsules with liposomes that contain active ingredients, such as retinol, vitamin C, or peptides, while maintaining the stability of both microcapsules and liposomes. This formulation provides sustained delivery of active ingredients to the skin, selectively targeting skin concerns while minimizing irritation. The composition effectively addresses skin aging by repairing damaged skin barriers, promoting collagen production, and reducing the appearance of fine lines and wrinkles.

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