Plasma-Rich Platelet Applications for Hair Growth

Decomposed platelet concentrate containing up to 50% intact platelets and at least 200 pg/ml RANTES, for preventing or treating hair loss and promoting hair growth. The decomposed platelet concentrate can also be used as a composition with body fat cells for cosmetic, reconstructive, and regenerative surgeries, pain relief treatments, and wound healing. The decomposed platelet concentrate is stored resuspended in liquid medium like plasma to prevent platelet lysis. It provides benefits like angiogenesis, collagen formation, and cell division for tissue regeneration when used in surgeries and wound healing.

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Hair regeneration solution for hair follicle microcomponents grafting that enables effective treatment of hair loss through a novel extraction and processing method. The solution combines trypsin, collagenase, and EDTA enzymes with autologous platelet-rich plasma (PRP) and serum to extract hair follicle microfibrils from collected scalp tissue. The extracted microfibrils are then processed in an enzymatic mixture while maintaining their viability and microenvironmental properties. This enzymatic extraction and processing method enables the creation of a hair regeneration solution that can be administered directly to the affected area, bypassing the need for mechanical disruption of hair follicles.

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A hair growth treatment paste containing concentrated growth factors that promotes hair regeneration through enhanced follicular microenvironmental support. The paste combines CGF solution extracted from human blood with white petroleum jelly, creating a synergistic delivery system that maintains cell viability and promotes hair growth. The treatment addresses the limitations of traditional hair loss treatments by delivering growth factors directly to the scalp, while also supporting blood supply and follicular differentiation.

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Composition and method for promoting hair follicle regeneration and growth through a synergistic blend of platelet-rich fibrin, acellular fat-activated protein, human collagen, and plant extracts. The composition contains platelet-rich fibrin, acellular lipoactive protein, human collagen, plant extracts, and physiological saline, which together support hair follicle regeneration and promote hair growth. The composition can be used to prevent hair loss and stimulate hair follicles to enter the growth phase, particularly in conditions of hormonal alopecia, congenital alopecia, and nutritional alopecia.

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Concentrated growth factor gel preparation for hair growth that combines autologous concentrated growth factors with a proprietary rheological modification. The gel formulation combines low molecular weight sodium hyaluronate and carbomer 940, which inhibit inflammation and promote tissue repair. The gel is prepared through a process that incorporates these components into a matrix, providing sustained delivery of growth factors while maintaining the gel's rheological properties. This formulation addresses the limitations of traditional growth factor treatments for hair loss by delivering potent growth factors directly to the site of hair follicle damage.

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Biological preparation for hair regeneration that combines platelet-rich plasma (PRP) with exosomes. The preparation contains high concentrations of platelets and exosomes derived from platelet activation, which are then combined to enhance hair growth. The platelets release growth factors that promote hair follicle regeneration, while the exosomes facilitate cell signaling and tissue repair. This preparation has been found to improve hair density, root diameter, and hair follicle distance compared to traditional PRP alone.

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A composition that promotes hair growth and/or hair restoration through the activation of AMPK and VEGF pathways in hair follicle stem cells. The composition, derived from a specific type of phospholipid called plasmalogen, enhances hair growth by promoting phosphorylation of AMPK and expression of VEGF in hair follicle stem cells. This leads to increased hair follicle activity and vascularization, resulting in improved hair growth and restoration.

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Composition for promoting hair regeneration, comprising platelet-rich plasma (PRP), adipose-derived stem cells, and autologous scalp hair follicle tissue fragments. The composition is prepared by centrifugation of autologous blood, fat-derived stem cells, and microtissue fragments from scalp hair follicles. The PRP component contains growth factors and cytokines that promote cell differentiation and tissue repair, while the stem cells and microtissue fragments enhance hair follicle regeneration through increased microvessel formation and cell proliferation.

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Platelet-rich plasma (PRP) derived from platelet-derived growth factor (PDGF)-secreting cells (PLCs) can be used to accelerate tissue repair and regeneration through localized application. The PLCs are cultured in a bioreactor environment to produce a concentrated source of PDGF, which is then isolated and purified. This concentrated PDGF can be administered directly to injured tissues, including musculoskeletal injuries, skin, and hair, to promote healing and regeneration. The PLC-derived PRP contains growth factors, cytokines, and other bioactive molecules that stimulate cellular proliferation, differentiation, and tissue repair processes. The composition can be formulated with additional therapeutic agents for enhanced efficacy.

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A stem cell complex for improving hair loss through targeted delivery of mesenchymal stem cells and platelet-rich plasma. The complex combines mesenchymal stem cells with platelet-rich plasma, which are then administered through microneedle injection into the scalp. The stem cells secrete growth factors and cytokines that promote hair follicle regeneration, while the platelet-rich plasma enhances angiogenesis and tissue repair. The treatment addresses hair loss by improving follicular nutrition and promoting hair cycle regulation, with systemic effects on inflammation and tissue balance.

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A method to enhance platelet-derived growth factors (PDGF) release from platelets, particularly in the preparation of hair growth promoters. The method involves removing red blood cells from umbilical cord blood, separating platelets from plasma, and then processing the platelets with thrombin to enhance their release of PDGF. This processing step, combined with repeated freezing and thawing, significantly increases the concentration of active PDGF in the final product. The resulting product is a concentrated solution of PDGF that can be used to promote hair growth.

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Modulating hair growth and activating hair follicle stem cells to treat hair loss conditions by targeting the Gas6-Tyro3/Axl/Mertk (TAM) signaling pathway. The method involves administering agents that increase Gas6 expression or activation, inhibit BMP signaling, or activate AXL to stimulate hair growth and stem cell activation. Alternatively, agents that decrease Gas6 expression, activate BMP signaling, or inhibit AXL can be used to decrease hair growth and stem cell activation. This provides a way to enhance or inhibit hair growth and stem cell activity as a therapy for hair loss conditions like telogen effluvium.

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Compositions, kits, and methods for increasing angiogenesis within the dermis and/or epidermis to treat hair loss. The compositions contain a peptide like GHK and a fullerene like C60. They can be sequentially applied topically to the scalp. The peptide stimulates angiogenesis and the fullerene enhances delivery. The kits provide separate containers of the peptide and fullerene compositions.

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Preparation method and application of exosome freeze-dried powder for hair growth. The method involves extracting platelet-rich plasma, purifying platelet-rich exosomes, and then freeze-drying the exosomes to create a stable, clinically relevant hair growth treatment. The exosomes retain their growth factor activity and can be easily stored and transported, making them a promising alternative to traditional hair growth treatments.

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A peptide that promotes hair growth by enhancing the proliferation of dermal papilla stem cells and their cytokine expression. The peptide, derived from erythropoietin, specifically targets the hair follicle growth phase by stimulating the proliferation of dermal papilla cells and their associated cytokines, thereby promoting hair growth. This peptide has been shown to be effective in promoting hair growth and has potential therapeutic applications for hair loss conditions.

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Composition for promoting hair growth or hair follicle regeneration and preventing or treating hair loss through the expression of basic fibroblast growth factor (bFGF) in a cost-effective manner. The composition comprises an effective amount of bFGF, preferably human bFGF, and any physiologically acceptable carrier, with no additional cell growth factors. The composition can be formulated for topical application or direct contact with the skin surface, and results in significant and rapid hair regeneration.

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Cosmetic composition for improving hair loss or promoting hair growth containing a cell growth promoting substance as an active ingredient. The composition comprises epidermal growth factor (EGF), basic fibroblast growth factor (bFGF), ascorbic acid, and N-acetyl-L-glutamine (NAG) in concentrations of 1-3 ng/ml, 90-110 ng/ml, 30-50 mM, and 90-110 mM, respectively. The composition enhances dermal papilla cell proliferation and collagen synthesis, thereby promoting hair growth and preventing hair loss.

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Non-thermal atmospheric plasma (NAP) treatment for hair growth and hair loss, comprising a medium selected from water, other aqueous media, and water-soluble media, and NAP generated from a plasma source. The treatment involves applying NAP to affected areas at least once a day for at least a month, using a medium that can be delivered through lipophilic or hydrophilic formulations.

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A composition for promoting hair growth or inhibiting hair loss that utilizes growth factors such as VEGF, FGFα, FGFB, TGF-β, IGF, KGF, and SCF to stimulate hair follicle regeneration and promote scalp capillary formation. The composition is administered topically to the affected scalp area for a period of 1-8 weeks, and is particularly effective in treating male pattern baldness and female pattern hair loss.

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Composition for promoting hair regeneration, comprising mitochondria and plasma, that enhances hair growth by repairing damaged hair follicle cells and promoting cell survival. The composition contains mitochondria and plasma, with the plasma containing growth factors like TGF-β1, PDGF-AA, PDGF-AB, and PDGF-BB. The plasma is prepared by separating plasma and cells from blood, then removing mitochondria from the plasma. The plasma is then mixed with the mitochondria, creating a plasma-mitochondria solution. This solution is applied directly to the scalp or injected into the hair follicles to promote hair growth.

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