Plasma-Rich Platelet Applications for Hair Growth

Decomposed platelet concentrate containing up to 50% intact platelets and at least 200 pg/ml RANTES, for preventing or treating hair loss and promoting hair growth. The decomposed platelet concentrate can also be used as a composition with body fat cells for cosmetic, reconstructive, and regenerative surgeries, pain relief treatments, and wound healing. The decomposed platelet concentrate is stored resuspended in liquid medium like plasma to prevent platelet lysis. It provides benefits like angiogenesis, collagen formation, and cell division for tissue regeneration when used in surgeries and wound healing.

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Hair regeneration solution for hair follicle microcomponents grafting that enables effective treatment of hair loss through a novel extraction and processing method. The solution combines trypsin, collagenase, and EDTA enzymes with autologous platelet-rich plasma (PRP) and serum to extract hair follicle microfibrils from collected scalp tissue. The extracted microfibrils are then processed in an enzymatic mixture while maintaining their viability and microenvironmental properties. This enzymatic extraction and processing method enables the creation of a hair regeneration solution that can be administered directly to the affected area, bypassing the need for mechanical disruption of hair follicles.

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A hair growth treatment paste containing concentrated growth factors that promotes hair regeneration through enhanced follicular microenvironmental support. The paste combines CGF solution extracted from human blood with white petroleum jelly, creating a synergistic delivery system that maintains cell viability and promotes hair growth. The treatment addresses the limitations of traditional hair loss treatments by delivering growth factors directly to the scalp, while also supporting blood supply and follicular differentiation.

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Composition and method for promoting hair follicle regeneration and growth through a synergistic blend of platelet-rich fibrin, acellular fat-activated protein, human collagen, and plant extracts. The composition contains platelet-rich fibrin, acellular lipoactive protein, human collagen, plant extracts, and physiological saline, which together support hair follicle regeneration and promote hair growth. The composition can be used to prevent hair loss and stimulate hair follicles to enter the growth phase, particularly in conditions of hormonal alopecia, congenital alopecia, and nutritional alopecia.

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Concentrated growth factor gel preparation for hair growth that combines autologous concentrated growth factors with a proprietary rheological modification. The gel formulation combines low molecular weight sodium hyaluronate and carbomer 940, which inhibit inflammation and promote tissue repair. The gel is prepared through a process that incorporates these components into a matrix, providing sustained delivery of growth factors while maintaining the gel's rheological properties. This formulation addresses the limitations of traditional growth factor treatments for hair loss by delivering potent growth factors directly to the site of hair follicle damage.

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Biological preparation for hair regeneration that combines platelet-rich plasma (PRP) with exosomes. The preparation contains high concentrations of platelets and exosomes derived from platelet activation, which are then combined to enhance hair growth. The platelets release growth factors that promote hair follicle regeneration, while the exosomes facilitate cell signaling and tissue repair. This preparation has been found to improve hair density, root diameter, and hair follicle distance compared to traditional PRP alone.

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A composition that promotes hair growth and/or hair restoration through the activation of AMPK and VEGF pathways in hair follicle stem cells. The composition, derived from a specific type of phospholipid called plasmalogen, enhances hair growth by promoting phosphorylation of AMPK and expression of VEGF in hair follicle stem cells. This leads to increased hair follicle activity and vascularization, resulting in improved hair growth and restoration.

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Composition for promoting hair regeneration, comprising platelet-rich plasma (PRP), adipose-derived stem cells, and autologous scalp hair follicle tissue fragments. The composition is prepared by centrifugation of autologous blood, fat-derived stem cells, and microtissue fragments from scalp hair follicles. The PRP component contains growth factors and cytokines that promote cell differentiation and tissue repair, while the stem cells and microtissue fragments enhance hair follicle regeneration through increased microvessel formation and cell proliferation.

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Platelet-rich plasma (PRP) derived from platelet-derived growth factor (PDGF)-secreting cells (PLCs) can be used to accelerate tissue repair and regeneration through localized application. The PLCs are cultured in a bioreactor environment to produce a concentrated source of PDGF, which is then isolated and purified. This concentrated PDGF can be administered directly to injured tissues, including musculoskeletal injuries, skin, and hair, to promote healing and regeneration. The PLC-derived PRP contains growth factors, cytokines, and other bioactive molecules that stimulate cellular proliferation, differentiation, and tissue repair processes. The composition can be formulated with additional therapeutic agents for enhanced efficacy.

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A stem cell complex for improving hair loss through targeted delivery of mesenchymal stem cells and platelet-rich plasma. The complex combines mesenchymal stem cells with platelet-rich plasma, which are then administered through microneedle injection into the scalp. The stem cells secrete growth factors and cytokines that promote hair follicle regeneration, while the platelet-rich plasma enhances angiogenesis and tissue repair. The treatment addresses hair loss by improving follicular nutrition and promoting hair cycle regulation, with systemic effects on inflammation and tissue balance.

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A method to enhance platelet-derived growth factors (PDGF) release from platelets, particularly in the preparation of hair growth promoters. The method involves removing red blood cells from umbilical cord blood, separating platelets from plasma, and then processing the platelets with thrombin to enhance their release of PDGF. This processing step, combined with repeated freezing and thawing, significantly increases the concentration of active PDGF in the final product. The resulting product is a concentrated solution of PDGF that can be used to promote hair growth.

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Modulating hair growth and activating hair follicle stem cells to treat hair loss conditions by targeting the Gas6-Tyro3/Axl/Mertk (TAM) signaling pathway. The method involves administering agents that increase Gas6 expression or activation, inhibit BMP signaling, or activate AXL to stimulate hair growth and stem cell activation. Alternatively, agents that decrease Gas6 expression, activate BMP signaling, or inhibit AXL can be used to decrease hair growth and stem cell activation. This provides a way to enhance or inhibit hair growth and stem cell activity as a therapy for hair loss conditions like telogen effluvium.

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Compositions, kits, and methods for increasing angiogenesis within the dermis and/or epidermis to treat hair loss. The compositions contain a peptide like GHK and a fullerene like C60. They can be sequentially applied topically to the scalp. The peptide stimulates angiogenesis and the fullerene enhances delivery. The kits provide separate containers of the peptide and fullerene compositions.

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Preparation method and application of exosome freeze-dried powder for hair growth. The method involves extracting platelet-rich plasma, purifying platelet-rich exosomes, and then freeze-drying the exosomes to create a stable, clinically relevant hair growth treatment. The exosomes retain their growth factor activity and can be easily stored and transported, making them a promising alternative to traditional hair growth treatments.

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A peptide that promotes hair growth by enhancing the proliferation of dermal papilla stem cells and their cytokine expression. The peptide, derived from erythropoietin, specifically targets the hair follicle growth phase by stimulating the proliferation of dermal papilla cells and their associated cytokines, thereby promoting hair growth. This peptide has been shown to be effective in promoting hair growth and has potential therapeutic applications for hair loss conditions.

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Composition for promoting hair growth or hair follicle regeneration and preventing or treating hair loss through the expression of basic fibroblast growth factor (bFGF) in a cost-effective manner. The composition comprises an effective amount of bFGF, preferably human bFGF, and any physiologically acceptable carrier, with no additional cell growth factors. The composition can be formulated for topical application or direct contact with the skin surface, and results in significant and rapid hair regeneration.

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Cosmetic composition for improving hair loss or promoting hair growth containing a cell growth promoting substance as an active ingredient. The composition comprises epidermal growth factor (EGF), basic fibroblast growth factor (bFGF), ascorbic acid, and N-acetyl-L-glutamine (NAG) in concentrations of 1-3 ng/ml, 90-110 ng/ml, 30-50 mM, and 90-110 mM, respectively. The composition enhances dermal papilla cell proliferation and collagen synthesis, thereby promoting hair growth and preventing hair loss.

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Non-thermal atmospheric plasma (NAP) treatment for hair growth and hair loss, comprising a medium selected from water, other aqueous media, and water-soluble media, and NAP generated from a plasma source. The treatment involves applying NAP to affected areas at least once a day for at least a month, using a medium that can be delivered through lipophilic or hydrophilic formulations.

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A composition for promoting hair growth or inhibiting hair loss that utilizes growth factors such as VEGF, FGFα, FGFB, TGF-β, IGF, KGF, and SCF to stimulate hair follicle regeneration and promote scalp capillary formation. The composition is administered topically to the affected scalp area for a period of 1-8 weeks, and is particularly effective in treating male pattern baldness and female pattern hair loss.

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Composition for promoting hair regeneration, comprising mitochondria and plasma, that enhances hair growth by repairing damaged hair follicle cells and promoting cell survival. The composition contains mitochondria and plasma, with the plasma containing growth factors like TGF-β1, PDGF-AA, PDGF-AB, and PDGF-BB. The plasma is prepared by separating plasma and cells from blood, then removing mitochondria from the plasma. The plasma is then mixed with the mitochondria, creating a plasma-mitochondria solution. This solution is applied directly to the scalp or injected into the hair follicles to promote hair growth.

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Composition for preventing hair loss or promoting hair growth comprising thrombopoietin, which enhances hair growth through a previously unknown mechanism. The composition, comprising thrombopoietin as an active ingredient, promotes hair growth by activating the thrombopoietin receptor, which stimulates the maturation and differentiation of giant cells. This leads to increased hair follicle activity and growth, particularly in cases of hair loss due to follicular damage.

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A method for stimulating hair growth through a combination of platelet-rich plasma (PRP) therapy and laser treatment. The treatment involves administering PRP to the scalp, followed by laser therapy that targets specific areas of hair loss. The laser treatment delivers high-intensity microwaves to the targeted areas, while PRP stimulates hair follicles from the surrounding scalp. This synergistic approach combines the regenerative properties of PRP with the targeted hair growth effects of laser therapy, resulting in enhanced hair density and growth.

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A novel hair growth treatment that utilizes a proprietary microneedle device to stimulate hair follicle regeneration through targeted growth factor delivery. The treatment involves a series of precise micro-injections of growth factors into specific hair follicle locations, where the microneedle penetrates the hair shaft to deliver the active ingredients. This minimally invasive approach enables controlled delivery of growth factors to the hair follicles, promoting hair growth and strengthening the hair follicle structure.

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A cytokine composition for promoting hair follicle regeneration through targeted cell manipulation. The composition enhances the natural growth factors present in hair follicles by altering their osmotic pressure through microneedle injection. This method enables controlled cell activation and differentiation in the hair follicle environment, leading to increased hair growth and regeneration.

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Composition and method for promoting hair growth and preventing hair loss through targeted delivery of growth factors. The composition combines platelet-rich plasma (PRP) with basic fibroblast growth factor (bFGF) in specific ratios to enhance hair follicle health. The bFGF, a potent growth factor, promotes hair growth while the PRP enhances blood supply to the scalp. The composition can be administered intradermally or subcutaneously to achieve hair growth and prevent hair loss.

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A composition for preventing or treating hair loss through targeted delivery of a protein transduction domain (PTD) conjugated to a therapeutic agent. The composition specifically binds to hair follicle cells, where the PTD delivers the therapeutic agent to the hair follicle, while the therapeutic agent promotes hair growth. The conjugation involves a linker that connects the PTD to the therapeutic agent, with the PTD having a modified cysteine residue for enhanced delivery. This composition enables controlled release of the therapeutic agent at the hair follicle site, while minimizing systemic side effects.

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A composition for improving hair and scalp health that strengthens hair, soothes the scalp, and alleviates skin inflammation. The composition is a mixture of stem cell culture solution, additives, and platelet-rich plasma (PRP) that is directly injected or stamped onto the scalp. The stem cell culture solution contains growth factors like collagen, laminin, HGF, vEGF, etc. The additives are copper peptide, biotin, panthenol, and pyridoxine. PRP provides autologous growth factors to promote scalp and hair regeneration.

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Base compositions for maintaining, prolonging, or enhancing the activity of platelet-rich plasma (PRP) in topical formulations. The compositions contain cell nutrients, biological buffers, viscosity-modifying agents, and botanical extracts that preserve PRP stability and biological activity for extended periods, typically up to 120 days. These compositions enable sustained PRP delivery in cosmetic applications, including skin treatments and hair restoration therapies.

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Composition for stimulating hair growth through a conditioned medium enriched with biologically active compounds from cultured mesenchymal stem cells (MSCs) under specific gaseous conditions. The composition contains a conditioned medium that contains enhanced concentrations of growth factors like Galectin-1, Thioredoxin, VEGF, and other factors critical for hair follicle development and maintenance. The composition is produced by MSCs cultured in a controlled environment with specific gas concentrations (CO, NO, H2S) that support optimal growth factor production. The composition is used as a therapeutic agent for hair loss conditions like alopecia, providing a novel approach to promoting hair growth through targeted cellular stimulation.

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A plasma-based method for promoting hair regeneration through targeted activation of hair follicle stem cells. The method employs plasma jets to deliver a controlled burst of ionized particles to the skin, specifically targeting hair follicle stem cells to enhance hair growth. The plasma composition and parameters can be tailored to optimize the therapeutic effect, with potential applications in hair restoration and regeneration.

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A hair growth composition that combines freeze-dried platelet-rich plasma (FDP-2B) with autologous serum, immune cells, vascular matrix component SVF, hair growth nutrient solution, and physiological saline. The composition provides a synergistic effect of growth factors, immune cells, and vascular matrix components that promote hair growth, improve scalp health, and shorten abnormal hair rest periods. The composition can be administered through various methods including injection, iontophoresis, laser therapy, and oral delivery.

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A hair follicle preservation solution for hair transplantation that enhances the survival rate of transplanted hair follicles. The solution combines a blood-derived matrix with specific growth factors and platelets that promote cellular regeneration and angiogenesis. The solution is applied to the transplantation site after hair follicle extraction, where it supports the natural healing process and promotes the survival of transplanted hair follicles.

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Composition for preventing hair loss or promoting hair growth that utilizes an active oxygen donor (ROS donor) as an active ingredient. The composition comprises an active oxygen donor that stimulates dermal papilla cells to proliferate, increase cell mobility, extend lifespan, and enhance hair growth. The active oxygen donor can be a compound that temporarily generates reactive oxygen species in specific cellular contexts, particularly in the hair follicle. The composition enables the delivery of this ROS donor to dermal papilla cells, where it promotes hair growth through enhanced proliferation, migration, and differentiation of these cells.

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A composition for preventing hair loss and promoting hair growth that utilizes platelet-derived growth factor-C (PDGF-C) as an active ingredient. The composition, which may be administered through topical application, demonstrates significant hair growth and prevention effects when combined with minoxidil, a well-established hair growth treatment. PDGF-C promotes hair growth by inducing cell proliferation and differentiation, and its synergistic effect with minoxidil enhances hair growth outcomes. The composition can be formulated as a suspension, cream, gel, patch, or other cosmetic product, offering a novel approach to hair loss treatment that addresses both hair growth and prevention.

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Hair growth agent comprising a combination of a growth factor and a delivery system. The agent specifically targets hair follicle stem cells and promotes their differentiation, preventing atrophy and degeneration. The growth factor enhances the microenvironment for hair root growth, ensuring sufficient nutrient supply and normal hair development. The agent can be delivered through a spray bottle, with the growth factor solution being dissolved before application. This formulation provides a stable and independent delivery system for the growth factor, enabling effective hair growth promotion without the need for complex formulation processes.

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A novel hair growth agent that activates proliferation of follicle dermal papilla cells. The agent, comprising an alkaline earth metal salt, specifically targets the proliferation of follicle dermal papilla cells, which are critical for hair growth. The agent's mechanism of action involves the activation of key genes involved in hair growth, including VEGF, FGF-7, ALPL, and tenascin C, while suppressing VEGF expression. This dual-action approach enables enhanced hair growth compared to conventional treatments, particularly in cases of male pattern baldness.

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A platelet concentrate for cosmetic and reconstructive treatments that combines reduced platelet concentration with enhanced growth factors. The concentrate contains less than 50% intact platelets, with a maximum concentration of 200 pg/ml RANTES, and is free of isotonic medium or platelet activators. This concentrate can be used in hair restoration, fat grafting, and cosmetic surgery, particularly in procedures requiring enhanced growth factors for tissue regeneration.

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A method for regenerating hair growth through systemic epigenetic modulation of the hair follicle's growth cycle. The treatment involves releasing platelets and leukocytes from the patient's blood, followed by their introduction into the hair follicle through injections. The patient's own blood is centrifuged to separate platelets and leukocytes, which are then combined with specific growth factors to stimulate hair growth. This approach targets the systemic regulation of the hair growth cycle, bypassing localized treatments that may not effectively address the underlying systemic issues contributing to hair loss.

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A novel treatment for diffuse hair loss that employs intradermal platelet-rich plasma (PRP) injections for sustained hair growth. The treatment involves administering platelet-rich plasma from the patient's own blood into the scalp through microinjections, with the plasma composition optimized to achieve a platelet concentration 6-8 times higher than normal. This platelet-rich plasma is then separated into pure platelet-poor plasma and platelet-rich plasma, with the latter being used for therapeutic applications. The treatment involves multiple injections spaced 0.5 cm apart, with the plasma composition and injection technique optimized to achieve maximum therapeutic efficacy while minimizing side effects.

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Cosmetically improving skin conditions by administering platelet-rich plasma (PRP) and autologous cell compositions after micro-needling. The micro-needling creates holes in the skin surface, which enhances absorption of the PRP and cell compositions beneath. The PRP contains growth factors that promote tissue regeneration, while autologous cells like fibroblasts, adipose cells, and stem cells further improve skin appearance. This multi-modal approach involves micro-needling, cell therapy, fillers, growth factor application, radiofrequency, and laser for conditions like scars, lines, stretch marks, hyperpigmentation, hair loss.

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A method for preparing an agent for treating alopecia through the selective enrichment of platelets and leukocytes from patient blood. The method involves a two-step centrifugation process that separates the blood components into distinct layers: red blood cells, white blood cells, and platelets. The platelet layer is further purified through a second centrifugation step at 1200 rpm for 10 minutes, resulting in a platelet-rich plasma (PRP) containing 1500-2000 * 10^9/L platelets and 20-30 * 10^9/L leukocytes. This enriched PRP is then used as a therapeutic agent for alopecia treatment, with the platelets delivering growth factors that promote hair growth.

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A hair growth promoting formulation that utilizes high concentrations of autologous plasma growth factors and calcium chloride to enhance hair follicle regeneration. The formulation is prepared through a process of plasma extraction from autologous blood, activation with calcium chloride, and gelification to release the growth factors. This autologous plasma formulation provides a concentrated source of bioactive growth factors that promote hair growth without the need for exogenous growth factors, making it a safe and effective treatment for hair loss.

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Platelet-derived growth factor (PDGF) is used to activate hair follicles and enhance hair growth by introducing PDGF solution into the scalp. The PDGF solution stimulates hair follicles to enter the growth phase, leading to increased hair volume and hairline advancement. The treatment can be administered using microneedle rollers, and the PDGF solution can be delivered through various methods, including topical application, microneedle therapy, or injection.

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Hair growth agent using platelet dry powder for promoting hair growth. The agent involves a formulation of platelet dry powder that is applied to the scalp to stimulate hair growth. The formulation contains platelet-derived growth factors and other bioactive molecules that promote hair follicle regeneration and hair growth. The agent can be administered through various methods, including topical application, and can be used to treat balding areas in both humans and animals.

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A method and apparatus for promoting hair growth in skin using micro-needling and platelet-rich plasma (PRP). The method involves traumatizing skin with a rolling device to activate stem cells in hair follicles. PRP is then infused into the area to form complexes with growth factors. The activated stem cells attach to the complexes and proliferate within the hair follicles, promoting hair growth. The apparatus has a roller to traumatize the skin and a chamber to hold and dispense the PRP.

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Pharmaceutical compositions and methods for treating hair loss and regenerating hair follicles through the administration of a suspension of hair progenitor cells (HPCs) obtained from a complete hair follicle and plasma-derived growth factors. The composition is prepared by enzymatically digesting hair follicle tissue and then re-suspending it in a plasma-derived growth factor solution. This composition is administered directly to the scalp to promote hair regeneration and follicular growth.

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A hair growth agent that utilizes platelet-derived growth factors as a novel active ingredient. The agent contains a concentrated solution of platelet-derived growth factors, specifically platelet-derived growth factor (PDGF), in a solvent and excipient. This solution is administered to the scalp to stimulate hair growth through enhanced cellular proliferation and differentiation. The PDGF solution is formulated to contain a specific concentration of PDGF cells, with optimal concentrations ranging from 1,500 to 15,000 cells per milliliter. The solution is administered through topical application, with the agent demonstrating significant hair growth-promoting effects on both the follicles and surrounding hair shafts.

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Intradermal pharmaceutical composition for preventing hair loss and promoting hair growth through targeted delivery of growth factors, biomimetic peptides, and nourishing complexes. The composition specifically targets the scalp's microcirculation and hair follicle biology to stimulate hair growth, particularly in balding areas. The formulation combines clinically effective concentrations of growth factors, biomimetic peptides, and nourishing complexes in a vehicle like distilled water, with optimal proportions for effective treatment of hair loss and promoting hair growth.

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