Methods for Follicular Stimulation and Hair Growth

Dual-wavelength laser system for hair loss treatment that uses lasers at two specific red wavelengths (650nm and 780nm) to stimulate hair follicles at different depths. The system has a placement seat with an operating table, laser arm, disinfectant storage box, and refrigerator. The laser device has a dual-wavelength laser diode, disinfectant nozzle, and air delivery pipes to spray iodine between treatments. It also has refrigerated air delivery to keep the treatment area cool.

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Compositions and methods for stimulating hair growth and treating hair loss using a compound called squaric acid di(trifluromethyl)propyl ester (CF3-SADBE). The compound is applied topically to hair follicles to increase hair growth and transition to the active anagen phase. It can also be used to treat hair loss beyond autoimmune alopecia conditions like alopecia areata. The compositions can include CF3-SADBE, diphenylcyclopropenone (DPCP), or a combination, along with other hair growth agents.

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Promoting hair growth and treating hair disorders like alopecia by inhibiting mitochondrial pyruvate oxidation in cells using compounds like JXL001. The compounds inhibit mitochondrial pyruvate carriers like MPC1. This enhances lactate production and LDH activity, which promotes hair growth. Administering the compounds topically or systemically can treat hair disorders.

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Composition for preventing hair loss and promoting hair growth containing specific natural compounds. The composition contains one or more of gypsogenin 3-O-β-D-glucuronopyranoside, deapioplatycodin D, congmunoside X, and chikusetsusaponin IVa as active ingredients. These compounds inhibit male hormone activity and suppress expression of a hair follicle catagen factor to transition hair growth from the shedding phase to the growth phase. The composition can be used in products like shampoo, tonic, lotion, hair oil, and functional foods to prevent hair loss and promote hair growth without side effects.

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Laser treatment to stimulate hair growth, regenerate damaged hair, prevent hair loss, and increase hair density. The method involves laser irradiation of hair follicles using a specific laser wavelength (1565 nm) to promote hair growth and improve hair quality. The laser treatment is done on areas of the scalp with thinning or missing hair to stimulate follicles and restore growth.

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Dual-mode laser hair growth device that combines focused laser acupuncture and diffused laser therapy to improve effectiveness for treating hair loss. The device has a head-worn body with separate assemblies emitting a focused laser for acupuncture and a diffused laser for scalp irradiation. This allows simultaneous targeted stimulation of acupuncture points and whole-head hair follicle activation for enhanced hair growth treatment compared to single-mode lasers.

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Modulating hair growth and activating hair follicle stem cells to treat hair loss conditions by targeting the Gas6-Tyro3/Axl/Mertk (TAM) signaling pathway. The method involves administering agents that increase Gas6 expression or activation, inhibit BMP signaling, or activate AXL to stimulate hair growth and stem cell activation. Alternatively, agents that decrease Gas6 expression, activate BMP signaling, or inhibit AXL can be used to decrease hair growth and stem cell activation. This provides a way to enhance or inhibit hair growth and stem cell activity as a therapy for hair loss conditions like telogen effluvium.

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Hair growth stimulant compound that promotes hair growth without affecting male hormone activation. The compound is represented by chemical formula 1: (R in formula 1 is hydrogen, hydroxyl, or methoxy). It promotes hair papilla cell proliferation, vascular endothelial growth factor (VEGF) production, and beta-catenin production. This compound can be used in hair growth products like cosmetics, quasi-drugs, and pharmaceuticals to promote hair growth and prevent hair loss without the side effects of hair loss drugs that suppress male hormone activation.

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Applicator for ameliorating alopecia, improving hair quality, and scalp condition using lasers. The applicator has multiple output points spaced close together to deliver laser light through hair. It splits a main laser beam into multiple partial beams using apertures or lenses. This allows targeted hairless skin treatment while avoiding excessive hair absorption. The close spacing prevents full hair coverage between points. This enables equal scalp coverage and repeatable protocols compared to spot-by-spot manual parting.

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Composition for promoting hair growth and/or improving white hair containing 2-O-ferloyl-L-malic acid. The compound is extracted from watercress and found to promote hair growth and/or reduce white hair by increasing R-spondin1 production in dermal papilla cells.

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Using electromagnetic fields to activate dermal papilla cells and promote hair growth, preventing or improving hair loss. The method involves treating hair follicles with an electromagnetic field having a frequency of 70 Hz and intensity of 10 G for 1 hour. This activates dermal papilla cells and promotes hair growth without apoptosis, preventing alopecia. The specific electromagnetic field parameters of 70 Hz frequency and 10 G intensity for 1 hour were found to increase dermal papilla cell activity and hair follicle growth.

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A composition for preventing hair loss and promoting hair growth containing specific plant-derived compounds. The composition includes at least one of Momordin Ic, Praticodin D2, Polygalacin D, Asiaticoside B, Bacopaside I, Notoginsenoside R2, Picfeltarraenin IB, Pseudoginsenoside RT5, Raddeanin A, Vina-ginsenoside R4, and Lipoglycoside II. These compounds enhance dermal papilla cell activity, promote mitochondrial activity, amplify Wnt/beta-catenin signaling, and inhibit male hormone action.

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A portable, compact, and easy-to-use device for home use of low-level laser therapy to treat hair loss. The device has a compact form factor and can be easily carried around. It provides convenient and accessible laser hair growth treatment for individuals with hair loss. The device is designed to deliver low-level laser therapy to stimulate hair growth. It uses LED diodes emitting light in the near-infrared spectrum to penetrate the scalp and promote cell metabolism, blood circulation, and collagen synthesis. The device is FDA-approved for hair loss treatment and provides an effective alternative to invasive hair transplants or medications. The device aims to improve hair growth and density by delivering targeted laser therapy in the comfort of one's home.

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A helmet for preventing hair loss using low-level laser therapy (LLLT) to stimulate hair growth. The helmet has LEDs arranged in a specific pattern on the inner skin to irradiate the scalp. The LEDs generate multiple wavelengths within 610-900nm. The LED arrangement forms hexagonal modules with a central LED surrounded by 6 peripheral LEDs. This configuration maximizes hair growth effects by increasing blood flow to the follicles, stimulating micronerves, muscles, and follicles, and penetrating laser light to multiple follicles.

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Promoting hair growth using compounds derived from papaya fermentation. The compounds, isopropyl 2,5-dihydroxybenzoate and related derivatives, are found in papaya fermented products. They promote hair growth when applied to the skin. The compounds can also be used as antioxidants. The papaya fermentation process involves steps like crushing papaya, adding sugar, aging, and fermenting.

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A light source device for hair growth that improves the efficiency and uniformity of low-level laser therapy for hair regrowth compared to existing devices. The device has a light source in a sleeve with a shaping element inside to shape the emitted light. This element has a wedge-shaped groove that gradually narrows towards the center. The shaping element focuses and directs the light from the source towards the scalp in a more concentrated and uniform pattern. It reduces scattering and blocking by surrounding hair, improving laser utilization and efficacy.

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Accelerating hair growth by targeting hair follicle stem cells (HFSCs) using a specific lactate dehydrogenase (LDH) isoform. The compound is a LDH inhibitor that selectively blocks LDH activity in HFSCs. Administering this compound to mice accelerates hair growth, improves hair thickness, and prevents hair loss. It does this by activating HFSCs and promoting their entry into the hair cycle. The compound selectively inhibits LDH in HFSCs without affecting LDH in other cells. This selectivity is achieved by targeting a specific LDH isoform (LDHA) expressed in HFSCs.

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Phototherapy device for promoting hair growth using pulsed light to activate hair follicle stem cells and induce hair follicle differentiation. The device is a light patch attached to the scalp that emits specific wavelengths of light in a fixed mode to stimulate hair growth. The patch has LEDs with wavelengths of 590-680nm arranged in a pattern on a flexible circuit. A control module regulates the LED brightness and timing.

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Promoting hair growth using compounds found in papaya fermented products. The compounds, isopropyl 2,5-dihydroxybenzoate and related derivatives, have an effect of promoting hair growth when applied to the skin. The compounds can be isolated from papaya fermented products, or the fermented products themselves can be used. They can also be used to make antioxidant compositions or functional foods for hair growth.

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A laser hair growth device using curved illuminating fibers to more uniformly irradiate the scalp with low-power lasers for hair growth promotion. The device has a laser source, curved illuminating fibers arranged in a special pattern, and a helmet-like structure to hold the fibers against the scalp. The curved fibers emit laser light from the scalp surface to stimulate hair growth. The fiber curvature conforms to the head shape for even coverage. The device aims to provide more consistent and effective laser hair growth compared to direct-mounted lasers on helmets or combs.

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Low-energy laser hair growth device with eye protection. The device uses low-power lasers to stimulate hair follicles and promote hair growth. It has safety features to prevent eye damage. It senses if the helmet is worn before turning on the lasers. If the helmet is not worn, it does not activate the lasers. This prevents accidentally looking directly at the lasers. It also blocks light inside the helmet to prevent viewing lasers through reflections. The device has pressure and light sensors on the helmet to detect wear.

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Laser hair growth device that expands the laser treatment area without increasing the number of laser heads to improve hair growth effectiveness without increasing safety risks. The device shapes the thin strip-shaped original laser spot into a larger rectangular, circular, or elliptical spot by using a light spot shaping unit. This allows adjacent laser heads to overlap and cover a larger area, homogenizing the light intensity. It promotes development of more hair follicle tissues without multiple laser doses that could cause discomfort or safety issues.

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Compounds to induce hair growth and hair regeneration. The compounds activate hair follicle stem cells (HFSCs) by increasing glycolysis. They have a structure with a cyclic ring system containing a nitrogen heterocycle fused to a carbocycle. The compounds can be administered to induce hair growth in individuals with hair loss conditions. The activation of HFSCs by the compounds promotes hair regrowth.

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Topical compositions for stimulating hair growth and treating hair loss that include bimatoprost, a compound approved for treating glaucoma, in combination with penetration enhancers. The penetration enhancers are used to improve absorption of the bimatoprost through the skin. The compositions are applied topically to promote hair growth and convert miniaturized hair into terminal hair. The penetration enhancers help deliver the bimatoprost deeper into the skin where it can more effectively stimulate hair growth.

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A low-power infrared laser hair growth stimulation device for promoting hair growth using diode lasers with wavelengths greater than 2,500 nm and power levels less than 1,000 mW collectively. The device has a laser band with diodes arranged close to the scalp that moves periodically over the head to stimulate hair follicles. The low-power infrared lasers disperse more than visible lasers, so fewer diodes are needed for scalp coverage. The close diode-scalp spacing and low power prevent thermal damage. The diode power levels are from 0-15 mW per diode, totaling less than 500 mW for all diodes. Multiple treatments are needed for hair growth stimulation.

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A handheld hair growth and scalp stimulation device that combines red and blue light therapy with microcurrent stimulation to improve hair growth and scalp health. The device has radiation sources emitting red and blue light, microcurrent electrodes, and options like cooling and vibration. It provides simultaneous red and blue light exposure, followed by microcurrent, to stimulate follicles, lock in treatments, kill bacteria, and restrict blood vessels. The device can be used for 5-15 minutes daily.

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Laser hair growth devices with optimized light delivery for hair loss treatment. The devices have features like concave emitter arrays, variable emitter activation sequences, and adjustable headgear to tailor light dosage to user hair loss levels. The devices also have modes to sequentially activate rows of emitters, deactivate rows, or emit bands of light to deliver optimal energy without overstimulation. The concave arrays of bristles and emitters on the devices contact the scalp during use. The adjustable headgear allows pivoting or sliding movement to optimize light coverage. This allows targeted, tailored treatment for hair loss prevention and regrowth.

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A laser hair growth device using a hemispherical light guide plate to more uniformly irradiate the scalp with laser light. The device has a hemispherical curved light guide plate, a reflective surface, a prism sheet, a laser source, and a fixed laser. The hemispherical shape of the light guide plate allows the laser light to be uniformly distributed over the curved surface of the scalp. This provides more even and effective hair growth stimulation compared to directly mounted lasers. The device also has peripheral components like a power supply, control circuit, and helmet structure.

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A new small molecule compound for promoting hair growth. The compound is a nitroxyl derivative with a specific structure containing a 3,5-dichloro-4-substituted phenoxy group. The compound can be synthesized from starting materials like 4-methoxyphenol and 1,2,3-trichloro-5-nitrobenzene.

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A novel compound for stimulating hair growth and preventing hair loss. The compound is a prostaglandin-flavonoid hybrid called C102, with the formula (Z)-S-C11-3-(4'-hydroxyphenyl)-4-oxo-4H-chromen-7-yl 7-((1 R,2R,3R,5S)-3,5-dihydroxy-2-(R-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoate. The compound promotes hair growth from dormant follicles and prevents hair fall. It can be synthesized by esterifying a prostaglandin analogue and a flavonoid.

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Low molecular weight heparin (LMWH) with reduced anticoagulant activity can promote hair growth. The LMWH has features like reduced anti-Xa and anti-Ha activity, lower glycol split uronic acid residues, and a weight average molecular weight between 3,500 and 8,000 Da. Administering this LMWH can increase hair growth in areas showing thinning or loss.

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Calcium-binding peptides that induce hair growth and nail growth in mammals. The peptides contain sequences like Asp-Ser-Ser (DSS) that bind tightly to calcium phosphate surfaces. When administered topically, they promote hair growth and nail regrowth. The calcium binding allows targeted delivery to mineralized tissues like hair follicles and nails. The peptides can also remineralize demineralized tissues like teeth and bone. They can be used to treat conditions like tooth decay, osteoporosis, and oral implant integration. The peptides can be circularized to improve stability.

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Hands-free wearable device for phototherapy to treat skin, scalp, and hair conditions like hair loss using LEDs. The device is a headband with an integrated canopy containing LEDs that emit therapeutic light. The canopy conforms to the scalp shape for even coverage. It has spacing columns to maintain distance from the scalp. The headband also has audio headphones and a control unit. The user wears it like a headband and the LEDs provide full scalp light therapy without manual movement. The audio helps relaxation during treatment. The device aims to provide complete and even scalp light distribution for conditions like hair loss using a headband structure that follows scalp curvature.

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Method for promoting hair growth using a compound called butenylbenzoquinone (BBQ) and its analogs to activate the Wnt signaling pathway. This pathway is involved in hair follicle growth. Applying BBQ or its analogs to the skin can stimulate hair growth without the side effects of other hair growth treatments like minoxidil or prostaglandin analogs. The BBQ compound activates Wnt signaling by binding to TCF sites and increasing beta-catenin levels in the nucleus. This promotes hair follicle regeneration.

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Optical hair growth stimulation device that can be used while lying down or sleeping without direct contact with the scalp. The device has bendable connections between the base and multiple light-emitting components. This allows the lights to be positioned above the scalp in a non-contact configuration. The lights can be controlled to stimulate hair growth without pressure or direct contact.

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A hair growth composition that synergistically enhances hair growth, prevents hair loss, promotes thicker and longer hair, and stimulates growth of eyelashes and eyebrows when combined with specific ingredients. The composition contains a hair growth agent, an epidermal stem cell functionality improver, and a DNA damage inhibitor. The stem cell improver supports hair follicle health and regeneration. The DNA damage inhibitor prevents genetic damage to hair cells. By combining these ingredients, the composition provides hair growth benefits beyond just the hair growth agent alone.

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A hair growth promotion treatment device that combines low power laser therapy with low frequency vibration to more effectively prevent hair loss. The device irradiates a specific wavelength light onto the scalp using low power laser therapy. It also applies weak vibrations to the scalp using low frequency vibration therapy. The combination of laser and vibration therapy is believed to activate cells in the scalp to promote hair growth and prevent hair loss. The device has a flexible printed circuit board with light emitting elements that can bend to conform to the scalp shape. This allows the laser light to be applied to the scalp. The vibration is applied using an elastic pad that mounts onto the device.

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Using compounds to treat hair disorders like hair loss, hair depigmentation, and alopecia. The compounds are modulators of peroxisome proliferator activated receptors (PPARs) that can stimulate hair growth and prevent hair disorders. The PPAR modulators are administered to subjects with hair disorders to improve hair growth and pigmentation. The compounds can be applied topically or taken orally. They modulate PPAR activity to treat hair disorders by promoting hair growth, preventing hair loss, and preventing hair depigmentation.

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Treating baldness, promoting hair growth, and/or promoting hair follicle development and activation on an area of the skin of a subject by subjecting the skin area to integumental perturbation. The method involves using devices that provide controlled, targeted mechanical stimulation to the skin to enhance hair growth. The devices can be handheld or motorized, and can have various shapes and attachment configurations. The skin perturbation can be used alone or in combination with other hair growth treatments.

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Hair growth device and method using light with specific wavelengths to stimulate hair growth without irritation. The device emits light at wavelengths equivalent to the absorption spectrum of water in the skin. This selective absorption activates the skin and stimulates hair growth. The device has emitters for 950 nm and 1450 nm light. The method involves irradiating the skin with these wavelengths to grow hair without medication or skin irritation.

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A comprehensive hair growth system that stimulates hair growth on the scalp using a combination of dietary supplements, scalp cleansing, and low-level laser therapy. The system involves ingesting a specific vitamin complex, washing the scalp with a sodium lauryl sulfate-free shampoo every 48 hours, and applying laser light with wavelength 380-1000 nm and flux 600-700 nW to the scalp for 1 hour once or four times a week over 1 year.

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A handheld device for stimulating hair growth using lasers and LEDs. The device has a laser diode and an LED in the head section that emits light between 655-470 nm. The laser stimulates blood flow and the LED reduces sebum production. The combined effect promotes hair growth. The laser dose is 3-4 J/cm2 in the 630-685 nm range.

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Method for reducing hair loss and promoting hair growth using a specific composition containing acids, antioxidants, and fatty acids. The composition can be applied to the skin or scalp to accelerate the onset of the anagen phase (active hair growth) and prevent hair loss. The composition contains acids like Kreb cycle intermediates and alpha-keto acids, antioxidants, and a mixture of saturated and unsaturated fatty acids.

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Flexible helmet with integrated light sources for non-invasive hair growth treatment. The helmet has a replaceable zone with multiple light emitting devices (LEDs, lasers) that covers specific scalp areas. Sensors detect when the helmet is worn and activate the lights. The helmet can be adjusted to maintain a consistent distance between the lights and scalp. It allows targeted, customized light therapy to stimulate hair growth, density, and scalp health without medications or side effects.

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Stimulating hair growth using light that avoids inflammation compared to drugs. The method involves irradiating hair roots with light in the 600-1000 nm range, except for 870-910 nm, to absorb a body component near the roots. This gentle, safe light stimulation promotes hair growth. The device has a cylindrical housing with LEDs emitting the specific wavelength range.

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Using a compound called pyrrolidine dithiocarbamate (PDTC) to prevent hair loss and stimulate hair growth. The compound, which is already known, is administered in a composition to prevent hair loss and stimulate hair growth in mammals like mice and rats. It works by preventing hair loss and promoting hair regrowth when given orally. The compound is a pharmaceutically acceptable salt of the formula I: The compound pyrrolidine dithiocarbamate (PDTC) is known in the art for its antioxidant and anti-inflammatory properties. The present invention discloses a novel use of this compound for preventing hair loss and stimulating hair growth. The composition can be administered orally to mammals like mice and rats to prevent hair loss and promote hair regrowth. This provides a potential new therapy for hair loss conditions in

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Modulating hair growth using low-power light to stimulate or inhibit hair growth without causing damage or pain. The method involves irradiating the area around hair roots with light in the 400-600nm range at energies of 0.01-1 joules per centimeter squared. This absorbed light activates components in the body like melanin, inflammatory cytokines, and proteins like p53 and mikobelka. This leads to cell death, alteration of cell ratios, and hair cycle changes to slow or accelerate hair growth.

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A hair loss prevention or induction wool pharmaceutical composition containing conditioned medium derived from cultured human adipose-derived stem cells. The composition is obtained by filtering the stem cell culture medium after incubation in serum-free conditions. It can be applied topically or injected into bald areas to prevent hair loss or promote hair growth. The conditioned medium contains factors from the stem cells that promote hair follicle growth and regeneration.

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A laser hair growth device that directly irradiates light and vibrations onto the scalp to stimulate hair growth. The device has conical protrusions on a flexible applicator that contact the scalp when worn as a cap. LEDs at the protrusion tips directly irradiate the scalp without hair interference. Temperature and pressure sensors monitor scalp conditions. This allows targeted light and vibration application to optimize hair growth without blocking by hair.

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Stimulating hair growth using low-power infrared lasers in a cap worn on the scalp. The cap has multiple low-power diode lasers emitting infrared light in the 2500-10000nm range. The lasers are arranged close to the scalp and move in a periodic cycle around the head using a motorized cap. The low-power infrared lasers stimulate hair follicles without damaging the scalp. The lasers are arranged at close distances to the scalp and operate at low power levels to avoid thermal damage. The cap moves the lasers over the scalp in a cyclic pattern. This allows the lasers to cover the scalp and stimulate hair growth.

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