Transdermal Delivery Mechanisms for Haircare Formulations

Nanovesicle-based topical drug delivery system for treating skin conditions like dermatitis, psoriasis, migraines, and acne. The system involves encapsulating drugs in ethosomes, a type of lipid-based vesicle, and applying them directly to the skin. The ethosomes enhance drug penetration through the skin barrier compared to traditional topicals. The drugs are dissolved in alcohol and combined with phospholipids, then shocked with hot water to form ethosomes. Additives like propylene glycol and glycerin further enhance stability and penetration. The ethosome mixture is then incorporated into a gel or lotion for application.

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Composition for enhancing transdermal absorption of topical cosmetics like creams, lotions, and serums. The composition contains a morpholine derivative like N-dodecyl morpholine, N-decyl morpholine, or N-tetradecyl-2-methoxy-6-hydroxymethylmorpholine, along with a transdermal absorption enhancer like laurocapram, sodium lauryl sulfate, or urea. The morpholine derivative helps fluidize the lipid layers of the skin barrier, while the enhancer further alters the barrier properties to improve absorption of active ingredients like collagen and hyaluronic acid.

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Flexible liposomes containing highly delivered Centella asiatica extract and madecassic acid, which are encapsulated in a lipid matrix. The liposomes are prepared through a novel method that enables efficient delivery of these active ingredients through the skin barrier. The liposomes contain a blend of polyol, liquid lipid, phospholipid, emulsifier, and the active ingredients, with a specific ratio of ingredients that balances delivery efficiency and skin penetration. The liposomes are designed to maintain their structure and integrity during storage and use, ensuring sustained delivery of the active ingredients.

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Low-impact method for making ceramide-based topical emulsions for improved absorption. The method involves making a concentrated, low-water ceramide emulsion by mixing ceramides, emulsifiers, and glycols to form a water-in-oil emulsion at low water concentrations. The resulting emulsion can then be diluted with water to form an oil-in-water emulsion for topical application. The low-water initial emulsion allows better absorption compared to traditional oil-in-water emulsions. The method uses glycols like propanediol instead of high-energy methods to reduce impact.

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Microneedle patches that deliver dual therapeutic effects through controlled transdermal delivery of natural compounds. The microneedles contain a matrix of chitosan, which slowly releases dihydromyricetin and hesperetin, a pair of natural polyphenols derived from traditional Chinese medicine. These compounds inhibit melanin production and prevent glycation, respectively, providing comprehensive anti-aging and whitening benefits. The microneedle patches can be used for sustained release of these natural compounds, offering a minimally invasive and painless delivery system for skin care products.

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Carrier composition for transdermal delivery of active substances that enables enhanced skin penetration through pH-dependent particle size changes. The composition comprises hyaluronic acid nanoparticles that exhibit pH-dependent particle size reduction, allowing them to form stable, controlled delivery systems. By maintaining a stable formulation even at high temperatures, the composition ensures consistent delivery of active substances through transdermal absorption. The pH-sensitive hyaluronic acid particles can be engineered to release their active substance in response to skin pH, facilitating targeted delivery.

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Double-layer lipid microsphere emulsion for targeted transdermal delivery of skin care actives. The emulsion has an outer layer of large lipid microsphere vesicles that penetrate the stratum corneum and granular layer, and an inner layer of nanolipid microsphere vesicles. The large vesicles carry water-based actives to the spinous layer, where they release the nanolipid microsphere cargo of oily actives. This allows both oil and water soluble actives to reach the deeper epidermis layers. The double-layer structure prevents premature release in the outer layers.

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Liposomes that enhance skin absorption and efficacy through enhanced adhesion and improved penetration. The liposomes contain collagen with an optimal content that optimizes skin penetration of skin active ingredients, including collagen, while maintaining skin adhesion. This formulation enables more effective delivery of skin rejuvenating agents to the skin surface, thereby improving skin texture and appearance.

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Anti-aging composition containing retinyl palmitate with enhanced stability and transdermal delivery. The composition comprises retinyl palmitate, aminobutyric acid, and arginine/lysine peptides, formulated with a combination of emulsifiers and solvents to achieve superior skin penetration and efficacy. The formulation is particularly effective in cosmetics formulations, particularly in creams, lotions, and gels, where skin penetration is critical.

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Lipid vesicles for intradermal delivery of anionic polymeric materials, such as hyaluronic acid, that enable below-surface skin penetration. The vesicles contain an anionic polymeric material encapsulated within a lipid bilayer, with an entrapped oil-in-water emulsion. This unique composition allows the anionic polymeric material to distribute below the skin surface while maintaining its beneficial skin properties.

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Green natural supramolecular liposome emulsion for skin care products that combines the benefits of natural emulsifiers and supramolecular stabilization with the advantages of supramolecular liposomes. The emulsion comprises a water-soluble phase and an oil-soluble phase, with natural emulsifiers and supramolecular materials incorporated into the oil phase. This formulation enables effective delivery of active ingredients through the skin barrier while maintaining skin health and preventing irritation. The emulsion is prepared through a simple and environmentally friendly process that replaces traditional emulsifiers with natural components.

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Formulations for topical delivery of active agents that enhance skin penetration while maintaining high saturation of the active ingredient and diffusion coefficient enhancer. The formulations incorporate a co-enhancer active ingredient delivery system with the aesthetics of cosmetic and cosmeceutical technology. The system includes a cosmetic active agent, a skin barrier repair combination, and a partition coefficient enhancer with a diffusion coefficient enhancer. The formulation utilizes a hydrocarbon-based silicone emollient excipient that maintains high saturation of both the active ingredient and diffusion coefficient enhancer, ensuring optimal skin penetration while preventing adverse effects typically associated with emollients.

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A hydroxy pinacolone retinoate supramolecular liposome preparation for improved cosmetic absorption and effectiveness. The liposome contains specific ratios of hydroxy pinacolone retinoate, isosorbide tincture dimethyl ether, polysorbate-60, poloxamer, sucrose laurate, and modified ceramide. The liposome is prepared by dissolving the components, mixing them, micronizing, and then nanometerizing to form the supramolecular liposome. This provides increased solubility, oil-water partitioning, and reduced skin barrier penetration resistance compared to conventional hydroxy pinacolone retinoate alone.

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A cosmetic composition that combines anti-aging and moisturizing properties with transdermal delivery capabilities. The formulation comprises a combination of ingredients including elastin, p-hydroxyacetophenone, fullerene, glycerin, glycerin glucose shake, xanthan gum, arginine, arginine/lysine peptide, soluble collagen, sodium chloride, hydroxypropyltetrahydropyrantriol, and gentian extract. The composition is formulated with a wetting agent, propylene glycol, and butylene glycol, and is designed to deliver active ingredients through the skin's dermal layer. The composition addresses skin aging by promoting collagen synthesis, improving skin elasticity, and enhancing cell vitality, while also addressing water loss through its moisturizing properties.

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Cosmetic composition for enhancing skin absorption of active ingredients through interaction with intercellular lipids in the stratum corneum. The composition comprises a nanoparticle delivery system containing a cholesterol derivative, along with ceramide, fatty acids, and hydrogenated lecithin. The delivery system forms a lamellar structure similar to skin lipids, enhances skin barrier function, and promotes absorption of bioactive substances through interaction with intercellular lipids.

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A cosmetic composition containing lipoic acid encapsulated within fullerene liposomes, which enhances skin hydration and firmness through targeted delivery of antioxidants and skin-protective agents. The composition comprises lipoic acid, fullerene liposomes, and a combination of humectants, emollients, and preservatives. The liposomes encapsulate the active ingredients in a stable, water-soluble form that penetrates deep into the skin, delivering sustained benefits through enhanced skin permeability.

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Cosmetic composition with enhanced stabilization and skin penetration of poorly soluble ingredients. The composition comprises a hydrotrope, a poorly soluble substance, and a carrier system. The hydrotrope stabilizes the poorly soluble substance, while the carrier system enhances its skin penetration. The composition contains a quantitative extract of Centella asiatica, including asiatic acid, ceramide, retinoid, coenzyme Q-10, ursolic acid, oleanolic acid, lipoic acid, etc.

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A transdermal delivery system for efficiently delivering molecules through the skin using nanoparticles with a lipophilic exterior and a hydrophilic core. The particles have a diameter of 10-200 nanometers and are prepared by polymerizing a hydrophilic monomer in water while dispersing oil-soluble agents in oil. This creates particles with a hydrophilic core surrounded by lipophilic side chains that allow penetration through the lipid-rich stratum corneum layer of skin. The hydrophilic molecules in the core pass through the water channels between cells while the lipophilic exterior is compatible with the lipids in skin. This enables transdermal delivery of hydrophilic molecules like drugs and nutrients through the skin barrier.

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A method for transdermally delivering dual therapeutic and cosmetic agents through a single device. The method employs a microneedle array with a high-aspect-ratio structure that enables controlled penetration of both therapeutic and cosmetic agents into the skin. The array's precise micropillars are designed to facilitate both drug delivery and cosmetic application simultaneously, allowing the same device to be used for both therapeutic and cosmetic purposes.

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Supramolecular liposomes encapsulating vitamin C, matrine, and ferulic acid deliver synergistic skin benefits through controlled release. The liposomes encapsulate these active ingredients in a lipophilic matrix, protecting them from environmental degradation while facilitating penetration through the skin barrier. The liposomes' aqueous core contains water-soluble ingredients like hyaluronic acid and glycerin, while the lipophilic outer layer contains the active ingredients. This dual encapsulation strategy enables sustained release of the active ingredients, enhancing their skin-whitening, anti-aging, and antiviral effects.

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A cream composition containing liposomes that improves skin elasticity through the delivery of bioactive ingredients. The composition comprises liposomes encapsulating bioactive ingredients like Fucus serrata extract and bird's nest acid, which are delivered through a freeze-drying process. The liposomes enhance the transdermal delivery of these bioactive ingredients, particularly in the skin's dermis, where they support collagen and elastin synthesis, inhibit glycosylation, and restore skin elasticity.

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A transdermal delivery system for enhanced skin penetration and therapeutic efficacy. The system utilizes a temperature-sensitive polymer as a skin barrier, with a liposome encapsulating the active ingredient. The liposome encapsulates the active ingredient in a hydrophobic environment, while the temperature-sensitive polymer maintains the liposome's integrity at body temperature. This combination enables rapid and sustained delivery of therapeutic agents through the skin, with enhanced permeation compared to traditional delivery methods.

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A lyophilized Rhodiola rosea liposome powder for skin care that enhances transdermal delivery and bioavailability. The powder is prepared through a freeze-drying process that incorporates Rhodiola rosea liposomes into a stable emulsion with moisturizing and antioxidant properties. The liposomes facilitate localized penetration into the skin's stratum corneum, while the emulsion formulation ensures effective delivery to the dermal layers. This formulation provides improved skin care benefits compared to traditional Rhodiola extracts, particularly in enhancing skin rejuvenation and anti-aging effects.

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Nano-liposomes containing idebenone and bisabolol, which exhibit synergistic antioxidant and whitening effects. The liposomes are engineered to enhance skin penetration of idebenone, a potent antioxidant, while also delivering its antioxidant properties through bisabolol. The liposomes achieve this through a unique phospholipid bilayer structure that enables precise drug distribution between hydrophilic and hydrophobic regions. The liposomes are prepared using oleic acid as a stabilizing agent, which enhances their stability and transdermal delivery.

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A system of transdermal enhancers for biologically active substances (BAS) that enables controlled penetration through the skin barrier. The system utilizes a proprietary blend of peptides and natural moisturizing factors to enhance the permeability of the stratum corneum, allowing for the delivery of active ingredients into the deeper dermal layers. The peptides, including peptides with anti-inflammatory and wound-healing properties, work synergistically with natural moisturizing factors to overcome the skin's natural barrier properties. This approach enables the delivery of biologically active substances through the skin without the need for traditional enhancers like dimethyl sulfoxide (DMSO) or surfactants.

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Nanoemulsion containing liposomes that encapsulate idebenone, with improved stability and skin absorption. The emulsion comprises liposomes in which idebenone is trapped, dispersed in an aqueous phase, and stabilized by a combination of emulsifiers and surfactants. The liposomes have a uniform particle size and high idebenone encapsulation efficiency, enabling enhanced skin penetration and efficacy.

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A transdermal delivery system comprising reverse micelles for enhanced skin penetration of hydrophobic active ingredients. The system utilizes reverse micelles that form in the intercellular space of the skin, where they capture hydrophobic substances that are naturally present in the stratum corneum. The reverse micelles are engineered to capture hydrophilic substances through their hydrophilic surface, enabling their delivery through the lipid barrier of the skin. This approach addresses the limitations of traditional micelles in penetrating the lipid-rich stratum corneum, while maintaining the stability of hydrophilic compounds.

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Composition for percutaneous absorption of a component through skin application, particularly through a W/O-type emulsified formulation. The composition maintains a stable emulsified state, with an aqueous phase comprising 70% or more by mass, stabilized by an oil gelling agent. The oil gelling agent is preferably a dextrin fatty acid ester or glycerin fatty acid ester. This formulation enables enhanced transdermal absorption of oil-soluble components, particularly for moisturizing and refreshing formulations, through skin application.

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Microneedle assembly formulation for skin treatment that enables precise and sustained delivery of active ingredients through a novel microneedle design. The formulation comprises a base polymer matrix with bio-soluble and thread-forming properties, an objective substance, and water. The base polymer matrix forms microneedles with a conical or pyramidal shape, while the objective substance is retained within the base matrix. The microneedles are designed to penetrate the skin through collision force, with secondary pressurization enhancing penetration depth. The formulation enables controlled release of the objective substance, allowing for targeted treatment of skin aging and scar conditions while maintaining stability over time.

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Liposome composition for enhanced transdermal delivery of active ingredients through improved skin penetration. The composition comprises hydrogenated lecithin, phosphatidylcholine, polysorbate 80, and lysolecithin, which form stable liposomes that exhibit enhanced water absorption rates compared to conventional emulsions. These liposomes are engineered to facilitate sustained skin penetration through their unique composition and structure, enabling more effective delivery of active ingredients across the skin barrier.

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A method for improving skin penetration and retention of topical treatments by delivering active ingredients at the skin-epidermal interface through biocompatible nanoparticles. The nanoparticles contain a combination of cosmetically active ingredients, including acids like tranexamic acid and alpha arbutin, which are released in a controlled manner to enhance skin penetration and retention. This approach enables targeted delivery of active ingredients to the skin's dermal-epidermal junction, where they can exert their therapeutic effects, while maintaining their efficacy and safety profile.

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A transdermal delivery system for enhancing skin penetration and improving cosmetic efficacy. The system comprises a percutaneous absorption promoting formulation containing ethoxylated caprylic/capric triglyceride, propylene glycol, ethoxylated hydrogenated castor oil, and lecithin/acrylic acid. The formulation is specifically designed to promote transdermal absorption, particularly in the epidermis, while maintaining its cosmetic benefits. The formulation is then formulated into a microemulsion that can be applied to the skin to deliver the active ingredients.

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A liposomal gel formulation of heparin A and B that enhances transdermal delivery and reduces skin irritation compared to conventional topical formulations. The formulation comprises a mixture of heparin A and B encapsulated in liposomes with a specific weight ratio, where the encapsulation efficiency is 83% and the average particle size is 390 nm. The liposomes exhibit superior anti-swelling properties compared to the conventional seven-leaf saponin formulation, demonstrating improved transdermal delivery and reduced skin irritation.

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A liposomal gel formulation of aescinate, a natural anti-inflammatory compound, that enhances transdermal delivery and reduces skin irritation compared to conventional sodium aescinate preparations. The liposomal formulation achieves improved entrapment efficiency and particle size control, resulting in enhanced anti-swelling efficacy.

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A triple nanoemulsion formulation for cosmetic products that enables targeted delivery of active ingredients across multiple skin layers while preventing penetration into the stratum corneum. The formulation combines three distinct nanoemulsions with different characteristics, which are optimized together to achieve efficient delivery of bioactive molecules in the epidermis, dermis, and hypodermis. This multi-layered delivery system ensures controlled release of active ingredients at specific sites of action while preventing penetration into the stratum corneum.

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A liposome structure that enhances transdermal delivery of active ingredients by creating a controlled delivery pathway through the skin barrier. The structure comprises an inner core with an active ingredient and a hydrophilic protective layer that faces the core's inner surface while the outer surface faces away. A hydrophobic region separates these surfaces, creating a unique liposome structure that facilitates rapid and efficient transdermal absorption. The protective layer can be engineered with compatible phospholipid molecules to enhance membrane integrity and facilitate the liposome's passage through the skin barrier.

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Transdermal delivery system for cosmetic and therapeutic agents that enables penetration through the skin barrier through inclusion body form. The system comprises a cosmetic composition comprising at least one cosmetic agent in inclusion body form, wherein the at least one cosmetic agent crosses the skin barrier in inclusion body form.

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A transdermal delivery system for enhancing transdermal permeation efficiency, comprising a liposome composition for transdermal delivery comprising 0.1 to 15% by weight of dilauramidoglutamide lysine, 0.005 to 8% by weight of labseed sterol, an active ingredient and the remainder of water, and cosmetics containing the same.

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Topical delivery system for stabilized protection agents and skin anti-aging agents that enables enhanced retention of the active ingredients on the skin. The system comprises a micelle-like suspension of the active agent, combined with a carrier that maintains the suspension structure, and a base composition that includes collagen. The micelle-like suspension is formed by encapsulating the active agent in a phospholipid micelle, which is stabilized by the carrier. The base composition provides the necessary collagen and elastin for skin integrity. This formulation enables the active agent to be delivered to the skin while maintaining its stability and retention properties.

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