Transdermal Delivery Mechanisms for Haircare Formulations

Nanovesicle-based topical drug delivery system for treating skin conditions like dermatitis, psoriasis, migraines, and acne. The system involves encapsulating drugs in ethosomes, a type of lipid-based vesicle, and applying them directly to the skin. The ethosomes enhance drug penetration through the skin barrier compared to traditional topicals. The drugs are dissolved in alcohol and combined with phospholipids, then shocked with hot water to form ethosomes. Additives like propylene glycol and glycerin further enhance stability and penetration. The ethosome mixture is then incorporated into a gel or lotion for application.

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Composition for enhancing transdermal absorption of topical cosmetics like creams, lotions, and serums. The composition contains a morpholine derivative like N-dodecyl morpholine, N-decyl morpholine, or N-tetradecyl-2-methoxy-6-hydroxymethylmorpholine, along with a transdermal absorption enhancer like laurocapram, sodium lauryl sulfate, or urea. The morpholine derivative helps fluidize the lipid layers of the skin barrier, while the enhancer further alters the barrier properties to improve absorption of active ingredients like collagen and hyaluronic acid.

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Flexible liposomes containing highly delivered Centella asiatica extract and madecassic acid, which are encapsulated in a lipid matrix. The liposomes are prepared through a novel method that enables efficient delivery of these active ingredients through the skin barrier. The liposomes contain a blend of polyol, liquid lipid, phospholipid, emulsifier, and the active ingredients, with a specific ratio of ingredients that balances delivery efficiency and skin penetration. The liposomes are designed to maintain their structure and integrity during storage and use, ensuring sustained delivery of the active ingredients.

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Low-impact method for making ceramide-based topical emulsions for improved absorption. The method involves making a concentrated, low-water ceramide emulsion by mixing ceramides, emulsifiers, and glycols to form a water-in-oil emulsion at low water concentrations. The resulting emulsion can then be diluted with water to form an oil-in-water emulsion for topical application. The low-water initial emulsion allows better absorption compared to traditional oil-in-water emulsions. The method uses glycols like propanediol instead of high-energy methods to reduce impact.

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Microneedle patches that deliver dual therapeutic effects through controlled transdermal delivery of natural compounds. The microneedles contain a matrix of chitosan, which slowly releases dihydromyricetin and hesperetin, a pair of natural polyphenols derived from traditional Chinese medicine. These compounds inhibit melanin production and prevent glycation, respectively, providing comprehensive anti-aging and whitening benefits. The microneedle patches can be used for sustained release of these natural compounds, offering a minimally invasive and painless delivery system for skin care products.

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Carrier composition for transdermal delivery of active substances that enables enhanced skin penetration through pH-dependent particle size changes. The composition comprises hyaluronic acid nanoparticles that exhibit pH-dependent particle size reduction, allowing them to form stable, controlled delivery systems. By maintaining a stable formulation even at high temperatures, the composition ensures consistent delivery of active substances through transdermal absorption. The pH-sensitive hyaluronic acid particles can be engineered to release their active substance in response to skin pH, facilitating targeted delivery.

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Double-layer lipid microsphere emulsion for targeted transdermal delivery of skin care actives. The emulsion has an outer layer of large lipid microsphere vesicles that penetrate the stratum corneum and granular layer, and an inner layer of nanolipid microsphere vesicles. The large vesicles carry water-based actives to the spinous layer, where they release the nanolipid microsphere cargo of oily actives. This allows both oil and water soluble actives to reach the deeper epidermis layers. The double-layer structure prevents premature release in the outer layers.

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Liposomes that enhance skin absorption and efficacy through enhanced adhesion and improved penetration. The liposomes contain collagen with an optimal content that optimizes skin penetration of skin active ingredients, including collagen, while maintaining skin adhesion. This formulation enables more effective delivery of skin rejuvenating agents to the skin surface, thereby improving skin texture and appearance.

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Anti-aging composition containing retinyl palmitate with enhanced stability and transdermal delivery. The composition comprises retinyl palmitate, aminobutyric acid, and arginine/lysine peptides, formulated with a combination of emulsifiers and solvents to achieve superior skin penetration and efficacy. The formulation is particularly effective in cosmetics formulations, particularly in creams, lotions, and gels, where skin penetration is critical.

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Lipid vesicles for intradermal delivery of anionic polymeric materials, such as hyaluronic acid, that enable below-surface skin penetration. The vesicles contain an anionic polymeric material encapsulated within a lipid bilayer, with an entrapped oil-in-water emulsion. This unique composition allows the anionic polymeric material to distribute below the skin surface while maintaining its beneficial skin properties.

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Green natural supramolecular liposome emulsion for skin care products that combines the benefits of natural emulsifiers and supramolecular stabilization with the advantages of supramolecular liposomes. The emulsion comprises a water-soluble phase and an oil-soluble phase, with natural emulsifiers and supramolecular materials incorporated into the oil phase. This formulation enables effective delivery of active ingredients through the skin barrier while maintaining skin health and preventing irritation. The emulsion is prepared through a simple and environmentally friendly process that replaces traditional emulsifiers with natural components.

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Formulations for topical delivery of active agents that enhance skin penetration while maintaining high saturation of the active ingredient and diffusion coefficient enhancer. The formulations incorporate a co-enhancer active ingredient delivery system with the aesthetics of cosmetic and cosmeceutical technology. The system includes a cosmetic active agent, a skin barrier repair combination, and a partition coefficient enhancer with a diffusion coefficient enhancer. The formulation utilizes a hydrocarbon-based silicone emollient excipient that maintains high saturation of both the active ingredient and diffusion coefficient enhancer, ensuring optimal skin penetration while preventing adverse effects typically associated with emollients.

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A hydroxy pinacolone retinoate supramolecular liposome preparation for improved cosmetic absorption and effectiveness. The liposome contains specific ratios of hydroxy pinacolone retinoate, isosorbide tincture dimethyl ether, polysorbate-60, poloxamer, sucrose laurate, and modified ceramide. The liposome is prepared by dissolving the components, mixing them, micronizing, and then nanometerizing to form the supramolecular liposome. This provides increased solubility, oil-water partitioning, and reduced skin barrier penetration resistance compared to conventional hydroxy pinacolone retinoate alone.

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A cosmetic composition that combines anti-aging and moisturizing properties with transdermal delivery capabilities. The formulation comprises a combination of ingredients including elastin, p-hydroxyacetophenone, fullerene, glycerin, glycerin glucose shake, xanthan gum, arginine, arginine/lysine peptide, soluble collagen, sodium chloride, hydroxypropyltetrahydropyrantriol, and gentian extract. The composition is formulated with a wetting agent, propylene glycol, and butylene glycol, and is designed to deliver active ingredients through the skin's dermal layer. The composition addresses skin aging by promoting collagen synthesis, improving skin elasticity, and enhancing cell vitality, while also addressing water loss through its moisturizing properties.

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Cosmetic composition for enhancing skin absorption of active ingredients through interaction with intercellular lipids in the stratum corneum. The composition comprises a nanoparticle delivery system containing a cholesterol derivative, along with ceramide, fatty acids, and hydrogenated lecithin. The delivery system forms a lamellar structure similar to skin lipids, enhances skin barrier function, and promotes absorption of bioactive substances through interaction with intercellular lipids.

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A cosmetic composition containing lipoic acid encapsulated within fullerene liposomes, which enhances skin hydration and firmness through targeted delivery of antioxidants and skin-protective agents. The composition comprises lipoic acid, fullerene liposomes, and a combination of humectants, emollients, and preservatives. The liposomes encapsulate the active ingredients in a stable, water-soluble form that penetrates deep into the skin, delivering sustained benefits through enhanced skin permeability.

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Cosmetic composition with enhanced stabilization and skin penetration of poorly soluble ingredients. The composition comprises a hydrotrope, a poorly soluble substance, and a carrier system. The hydrotrope stabilizes the poorly soluble substance, while the carrier system enhances its skin penetration. The composition contains a quantitative extract of Centella asiatica, including asiatic acid, ceramide, retinoid, coenzyme Q-10, ursolic acid, oleanolic acid, lipoic acid, etc.

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A transdermal delivery system for efficiently delivering molecules through the skin using nanoparticles with a lipophilic exterior and a hydrophilic core. The particles have a diameter of 10-200 nanometers and are prepared by polymerizing a hydrophilic monomer in water while dispersing oil-soluble agents in oil. This creates particles with a hydrophilic core surrounded by lipophilic side chains that allow penetration through the lipid-rich stratum corneum layer of skin. The hydrophilic molecules in the core pass through the water channels between cells while the lipophilic exterior is compatible with the lipids in skin. This enables transdermal delivery of hydrophilic molecules like drugs and nutrients through the skin barrier.

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A method for transdermally delivering dual therapeutic and cosmetic agents through a single device. The method employs a microneedle array with a high-aspect-ratio structure that enables controlled penetration of both therapeutic and cosmetic agents into the skin. The array's precise micropillars are designed to facilitate both drug delivery and cosmetic application simultaneously, allowing the same device to be used for both therapeutic and cosmetic purposes.

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Supramolecular liposomes encapsulating vitamin C, matrine, and ferulic acid deliver synergistic skin benefits through controlled release. The liposomes encapsulate these active ingredients in a lipophilic matrix, protecting them from environmental degradation while facilitating penetration through the skin barrier. The liposomes' aqueous core contains water-soluble ingredients like hyaluronic acid and glycerin, while the lipophilic outer layer contains the active ingredients. This dual encapsulation strategy enables sustained release of the active ingredients, enhancing their skin-whitening, anti-aging, and antiviral effects.

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