Formulations for Exosome-Based Skin Regeneration

A composition containing stem cell exosomes and its application in preparing products containing repair effects. The composition combines umbilical cord mesenchymal stem cells with purslane extract, seaweed polysaccharide, and other natural extracts to enhance skin repair. The stem cell exosomes regulate skin cell proliferation and differentiation while purslane extract provides barrier repair properties, while seaweed polysaccharide contributes to skin elasticity. The composition can be formulated into topical products such as creams, serums, or masks to deliver these beneficial components to the skin.

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Stem cell exosomes for skin regeneration that enhance keratinocyte proliferation and function after UV damage. The exosomes are derived from umbilical cord-derived stem cells treated with Atractylodes polysaccharide, which improves their exocytotic release and bioactivity. These exosomes are then used to accelerate wound healing by promoting keratinocyte proliferation and migration in damaged skin. The exosomes can be encapsulated in a gel matrix for topical delivery, providing a sustained release of therapeutic factors for rapid skin regeneration.

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A mesodermal anti-aging exosome mixture containing exosomes derived from fibroblasts and exosomes derived from mesenchymal stem cells. The exosome mixture is prepared by culturing fibroblasts and mesenchymal stem cells separately, harvesting and purifying the exosomes from their culture media, and mixing them in a 1:1 volume ratio to obtain the anti-aging exosome mixture. The fibroblast-derived exosomes promote collagen synthesis, elastin production, and extracellular matrix remodeling for skin firmness and elasticity. Mesenchymal stem cell-derived exosomes modulate immune responses, promote angiogenesis, and secrete growth factors for skin rejuvenation and aging reduction. The exosome mixture contains at least 2*10^9 exosomes

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A stem cell exosome-based skin repair preparation that uses stem cell exosomes along with specific additives to enhance skin regeneration and wound healing. The stem cell exosomes are derived from human umbilical cord blood mesenchymal stem cells. The preparation also contains additives like sea fennel extract, ceramide, astaxanthin, wolfberry polysaccharide, vitamin E, and carbomer. These additives are selected based on their skin regeneration properties. The stem cell exosomes and additives are combined to create a skin repair preparation that promotes faster wound healing, scar reduction, and improved skin texture by stimulating fibroblast activity and collagen synthesis.

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Composition for cosmetic use that combines exosomes, growth factors, and MSC-derived components to enhance skin health and appearance. The composition comprises exosomes, one or more growth factors, MSC-derived fragments, and a water-soluble emollient. The growth factors include VEGF, FGF, IL-6, CTGF, PDGF, PGE2, IL-10, HLA-G5, galectin 1, LIF, MHCH, EGF, TGF-β, IGF-1, KGF, SDF-1, MIP-lb, and MIP-1a, while MSC-derived fragments include placenta hydrolyzate, portulaca oleracea DNA, and phenoxyethanol. The composition maintains a pH of 6.5 and has a stable stability profile.

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Composition for promoting human skin fibroblast growth and enhancing skin care efficacy through synergistic delivery of stem cell exosomes and recombinant humanized collagen. The composition combines stem cell exosomes with recombinant humanized collagen in a specific ratio, where the collagen concentration is optimized to enhance cell migration and proliferation while maintaining optimal exosome stability. This formulation enables enhanced skin regeneration and repair capabilities compared to traditional stem cell exosomes or collagen alone.

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A method for preparing skin organoids that enhance anti-aging and photoaging repair through targeted exosome secretion. The preparation involves culturing dermal fibroblasts and epidermal keratinocytes in a specific ratio, then applying mechanical and physiological stimulation to enhance exosome production. The exosomes are then isolated and characterized for their therapeutic efficacy in repairing skin defects and promoting collagen synthesis. The method leverages the unique characteristics of dermal fibroblasts and epidermal keratinocytes to create a targeted delivery system for exosomes that can be optimized for specific skin conditions.

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A stem cell-derived exosome skin homeostasis agent loaded with THC, comprising exosomes encapsulating THC, that effectively restores skin barrier function and maintains tissue homeostasis. The agent combines stem cell-derived exosomes with THC, which are encapsulated in uniform exosomes with higher THC concentrations, to deliver therapeutic benefits through direct cell-to-cell communication and immune regulation. The exosomes contain skin barrier proteins, detoxification enzymes, and other bioactive molecules that promote tissue repair and immune regulation, while the THC enhances the exosomes' therapeutic effects.

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Edelweiss-derived exosomes for skin rejuvenation and wound healing, comprising exosomes secreted by plant stem cells. These exosomes contain bioactive factors regulating cellular behaviors, including collagen synthesis, cell migration, and tissue regeneration. The exosomes are isolated from conditioned media of plant stem cells and have been shown to improve skin elasticity, reduce wrinkles, promote skin regeneration, and enhance anti-inflammatory responses.

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Exosomes derived from mesenchymal stem cells (MSCs) play a critical role in intercellular communication by releasing bioactive molecules that affect tissue regeneration and immune responses. MSC-derived exosomes contain proteins, microRNAs, and metabolites that are transferred to recipient cells, influencing cell proliferation, migration, and gene expression. These exosomes can be isolated from tissue and blood, providing a cell-free system for therapeutic applications. By targeting specific exosomal components, exosomes can be engineered to deliver therapeutic effects, including modulating immune responses and promoting tissue repair, without the need for cell-cell contact.

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Umbilical cord mesenchymal stem cell exosomes with enhanced miR-328-3p expression promote skin barrier repair through improved proliferation and matrix composition. These exosomes, derived from umbilical cord mesenchymal stem cells, exhibit increased expression of miR-328-3p, a microRNA involved in cell differentiation and proliferation. The exosomes enhance dermal fibroblast proliferation and matrix production, particularly in the context of skin aging, by regulating key collagen and elastin genes. This exosomal delivery system has potential applications in anti-aging skin care products and therapies.

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Cosmetic composition and skin regeneration preparation containing exosomes isolated from skin cells, particularly keratinocytes, for promoting skin regeneration and wound healing. The exosomes derived from skin cells stimulate proliferation and migration of skin cells like keratinocytes and fibroblasts. The composition can have exosomes at concentrations of 1-100 µg/ml. The exosomes can be obtained by isolating them from skin cell cultures. The composition can be used as a cosmetic ingredient to promote skin regeneration. The exosomes contain denatured proteins and untransformed lipids when heated, indicating they have heat-labile factors that stimulate skin cell proliferation and migration.

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Preparation of three-dimensional cultured mesenchymal stem cell exosomes for skin injury repair and regeneration through a novel method of isolating and characterizing exosomes from three-dimensional cultured mesenchymal stem cells. The exosomes are extracted from sheep mesenchymal stem cells cultured in a three-dimensional matrix, characterized by enhanced paracrine activity compared to traditional two-dimensional cultured cells, and demonstrated to promote wound healing through mechanisms including immune regulation and tissue regeneration.

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Nano-encapsulated adipose stem cell exosome composition for promoting skin regeneration and repair. The composition contains adipose stem cell exosomes, trehalose, Boseine, small molecule hyaluronic acid, nicotinamide, oligopeptide-1, tetrapeptide-1, nonapeptide-1, fullerene, emulsifier, and water. The exosomes are nano-encapsulated using shearing to improve their ability to promote epithelial cell proliferation for skin regeneration.

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Placental-derived exosomes for skin rejuvenation, specifically targeting skin aging by promoting cellular regeneration and collagen synthesis. The exosomes contain active peptides that enhance fibroblast proliferation and collagen production, restoring skin elasticity and reducing wrinkles. The exosomes are prepared through a novel method of peptide encapsulation, ensuring precise delivery of the active compounds to target cells. This innovative approach enables targeted delivery of anti-aging peptides to skin tissues, offering a novel solution for skin rejuvenation and cosmetic applications.

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A medical patch that combines exosomes with adipose-derived stem cells to enhance skin regeneration. The patch contains exosomes derived from adipose-derived stem cells, vitamin C, and chitosan, which are processed to remove contaminants and preserve their therapeutic properties. The exosomes are then incorporated into a hydrogel matrix, where they release their therapeutic effects through paracrine mechanisms. The patch promotes epidermal cell proliferation, migration, and wound healing, providing a novel approach to skin repair that addresses the limitations of traditional laser treatments.

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Preparation method and application of biological polypeptides and stem cell exosomes for skin anti-aging and wound healing. The method involves the cultivation of stem cells, collection of their supernatant, and subsequent preparation of stem cell exosomes. These exosomes are engineered to contain bioactive polypeptides that promote microcirculation, angiogenesis, and capillary network repair, while maintaining their natural safety profile. The exosomes can be applied directly to skin tissues to enhance wound healing and prevent restenosis, offering a novel, non-invasive solution for anti-aging and tissue repair.

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Exosomes derived from human umbilical cord mesenchymal stem cells (UC-MSCs) that selectively enhance skin regeneration by modulating dermal fibroblast function. These exosomes, engineered to express miR-328-3p, specifically target and up-regulate genes involved in fibroblast proliferation and collagen production, while simultaneously inhibiting fibroblast degradation. This targeted approach enables the delivery of therapeutic benefits to the skin through exosomes, with potential applications in anti-aging treatments.

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A composition containing fibroblast-derived extracellular vesicles for treating skin and mucosal wounds. The composition can be applied topically to accelerate wound healing. The fibroblast-derived extracellular vesicles promote wound healing by enhancing cell proliferation, migration, angiogenesis, and collagen deposition. The composition provides a rapid and effective therapeutic option for skin and mucosal wounds compared to conventional mesenchymal stem cell-derived extracellular vesicles.

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A gel cosmetic that combines mesenchymal stem cell exosomes with skin repair components to address skin concerns. The gel contains exosomes derived from mesenchymal stem cells, which are highly effective in skin repair, possess low immunogenicity, and are non-irritating. The exosomes enhance skin barrier function, promote transdermal absorption, and exhibit anti-inflammatory and antibacterial properties. The gel also incorporates moisturizing agents like glycerin, hyaluronic acid, and ceramide to enhance skin hydration and protection. This innovative gel addresses the limitations of existing skin repair products by combining the potent skin repair benefits of exosomes with comprehensive moisturizing and barrier-enhancing properties.

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