Formulations for Exosome-Based Skin Regeneration

A composition containing stem cell exosomes and its application in preparing products containing repair effects. The composition combines umbilical cord mesenchymal stem cells with purslane extract, seaweed polysaccharide, and other natural extracts to enhance skin repair. The stem cell exosomes regulate skin cell proliferation and differentiation while purslane extract provides barrier repair properties, while seaweed polysaccharide contributes to skin elasticity. The composition can be formulated into topical products such as creams, serums, or masks to deliver these beneficial components to the skin.

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Stem cell exosomes for skin regeneration that enhance keratinocyte proliferation and function after UV damage. The exosomes are derived from umbilical cord-derived stem cells treated with Atractylodes polysaccharide, which improves their exocytotic release and bioactivity. These exosomes are then used to accelerate wound healing by promoting keratinocyte proliferation and migration in damaged skin. The exosomes can be encapsulated in a gel matrix for topical delivery, providing a sustained release of therapeutic factors for rapid skin regeneration.

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A mesodermal anti-aging exosome mixture containing exosomes derived from fibroblasts and exosomes derived from mesenchymal stem cells. The exosome mixture is prepared by culturing fibroblasts and mesenchymal stem cells separately, harvesting and purifying the exosomes from their culture media, and mixing them in a 1:1 volume ratio to obtain the anti-aging exosome mixture. The fibroblast-derived exosomes promote collagen synthesis, elastin production, and extracellular matrix remodeling for skin firmness and elasticity. Mesenchymal stem cell-derived exosomes modulate immune responses, promote angiogenesis, and secrete growth factors for skin rejuvenation and aging reduction. The exosome mixture contains at least 2*10^9 exosomes

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A stem cell exosome-based skin repair preparation that uses stem cell exosomes along with specific additives to enhance skin regeneration and wound healing. The stem cell exosomes are derived from human umbilical cord blood mesenchymal stem cells. The preparation also contains additives like sea fennel extract, ceramide, astaxanthin, wolfberry polysaccharide, vitamin E, and carbomer. These additives are selected based on their skin regeneration properties. The stem cell exosomes and additives are combined to create a skin repair preparation that promotes faster wound healing, scar reduction, and improved skin texture by stimulating fibroblast activity and collagen synthesis.

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Composition for cosmetic use that combines exosomes, growth factors, and MSC-derived components to enhance skin health and appearance. The composition comprises exosomes, one or more growth factors, MSC-derived fragments, and a water-soluble emollient. The growth factors include VEGF, FGF, IL-6, CTGF, PDGF, PGE2, IL-10, HLA-G5, galectin 1, LIF, MHCH, EGF, TGF-β, IGF-1, KGF, SDF-1, MIP-lb, and MIP-1a, while MSC-derived fragments include placenta hydrolyzate, portulaca oleracea DNA, and phenoxyethanol. The composition maintains a pH of 6.5 and has a stable stability profile.

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Composition for promoting human skin fibroblast growth and enhancing skin care efficacy through synergistic delivery of stem cell exosomes and recombinant humanized collagen. The composition combines stem cell exosomes with recombinant humanized collagen in a specific ratio, where the collagen concentration is optimized to enhance cell migration and proliferation while maintaining optimal exosome stability. This formulation enables enhanced skin regeneration and repair capabilities compared to traditional stem cell exosomes or collagen alone.

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A method for preparing skin organoids that enhance anti-aging and photoaging repair through targeted exosome secretion. The preparation involves culturing dermal fibroblasts and epidermal keratinocytes in a specific ratio, then applying mechanical and physiological stimulation to enhance exosome production. The exosomes are then isolated and characterized for their therapeutic efficacy in repairing skin defects and promoting collagen synthesis. The method leverages the unique characteristics of dermal fibroblasts and epidermal keratinocytes to create a targeted delivery system for exosomes that can be optimized for specific skin conditions.

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A stem cell-derived exosome skin homeostasis agent loaded with THC, comprising exosomes encapsulating THC, that effectively restores skin barrier function and maintains tissue homeostasis. The agent combines stem cell-derived exosomes with THC, which are encapsulated in uniform exosomes with higher THC concentrations, to deliver therapeutic benefits through direct cell-to-cell communication and immune regulation. The exosomes contain skin barrier proteins, detoxification enzymes, and other bioactive molecules that promote tissue repair and immune regulation, while the THC enhances the exosomes' therapeutic effects.

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Edelweiss-derived exosomes for skin rejuvenation and wound healing, comprising exosomes secreted by plant stem cells. These exosomes contain bioactive factors regulating cellular behaviors, including collagen synthesis, cell migration, and tissue regeneration. The exosomes are isolated from conditioned media of plant stem cells and have been shown to improve skin elasticity, reduce wrinkles, promote skin regeneration, and enhance anti-inflammatory responses.

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Exosomes derived from mesenchymal stem cells (MSCs) play a critical role in intercellular communication by releasing bioactive molecules that affect tissue regeneration and immune responses. MSC-derived exosomes contain proteins, microRNAs, and metabolites that are transferred to recipient cells, influencing cell proliferation, migration, and gene expression. These exosomes can be isolated from tissue and blood, providing a cell-free system for therapeutic applications. By targeting specific exosomal components, exosomes can be engineered to deliver therapeutic effects, including modulating immune responses and promoting tissue repair, without the need for cell-cell contact.

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Umbilical cord mesenchymal stem cell exosomes with enhanced miR-328-3p expression promote skin barrier repair through improved proliferation and matrix composition. These exosomes, derived from umbilical cord mesenchymal stem cells, exhibit increased expression of miR-328-3p, a microRNA involved in cell differentiation and proliferation. The exosomes enhance dermal fibroblast proliferation and matrix production, particularly in the context of skin aging, by regulating key collagen and elastin genes. This exosomal delivery system has potential applications in anti-aging skin care products and therapies.

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Cosmetic composition and skin regeneration preparation containing exosomes isolated from skin cells, particularly keratinocytes, for promoting skin regeneration and wound healing. The exosomes derived from skin cells stimulate proliferation and migration of skin cells like keratinocytes and fibroblasts. The composition can have exosomes at concentrations of 1-100 µg/ml. The exosomes can be obtained by isolating them from skin cell cultures. The composition can be used as a cosmetic ingredient to promote skin regeneration. The exosomes contain denatured proteins and untransformed lipids when heated, indicating they have heat-labile factors that stimulate skin cell proliferation and migration.

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Preparation of three-dimensional cultured mesenchymal stem cell exosomes for skin injury repair and regeneration through a novel method of isolating and characterizing exosomes from three-dimensional cultured mesenchymal stem cells. The exosomes are extracted from sheep mesenchymal stem cells cultured in a three-dimensional matrix, characterized by enhanced paracrine activity compared to traditional two-dimensional cultured cells, and demonstrated to promote wound healing through mechanisms including immune regulation and tissue regeneration.

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Nano-encapsulated adipose stem cell exosome composition for promoting skin regeneration and repair. The composition contains adipose stem cell exosomes, trehalose, Boseine, small molecule hyaluronic acid, nicotinamide, oligopeptide-1, tetrapeptide-1, nonapeptide-1, fullerene, emulsifier, and water. The exosomes are nano-encapsulated using shearing to improve their ability to promote epithelial cell proliferation for skin regeneration.

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Placental-derived exosomes for skin rejuvenation, specifically targeting skin aging by promoting cellular regeneration and collagen synthesis. The exosomes contain active peptides that enhance fibroblast proliferation and collagen production, restoring skin elasticity and reducing wrinkles. The exosomes are prepared through a novel method of peptide encapsulation, ensuring precise delivery of the active compounds to target cells. This innovative approach enables targeted delivery of anti-aging peptides to skin tissues, offering a novel solution for skin rejuvenation and cosmetic applications.

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A medical patch that combines exosomes with adipose-derived stem cells to enhance skin regeneration. The patch contains exosomes derived from adipose-derived stem cells, vitamin C, and chitosan, which are processed to remove contaminants and preserve their therapeutic properties. The exosomes are then incorporated into a hydrogel matrix, where they release their therapeutic effects through paracrine mechanisms. The patch promotes epidermal cell proliferation, migration, and wound healing, providing a novel approach to skin repair that addresses the limitations of traditional laser treatments.

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Preparation method and application of biological polypeptides and stem cell exosomes for skin anti-aging and wound healing. The method involves the cultivation of stem cells, collection of their supernatant, and subsequent preparation of stem cell exosomes. These exosomes are engineered to contain bioactive polypeptides that promote microcirculation, angiogenesis, and capillary network repair, while maintaining their natural safety profile. The exosomes can be applied directly to skin tissues to enhance wound healing and prevent restenosis, offering a novel, non-invasive solution for anti-aging and tissue repair.

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Exosomes derived from human umbilical cord mesenchymal stem cells (UC-MSCs) that selectively enhance skin regeneration by modulating dermal fibroblast function. These exosomes, engineered to express miR-328-3p, specifically target and up-regulate genes involved in fibroblast proliferation and collagen production, while simultaneously inhibiting fibroblast degradation. This targeted approach enables the delivery of therapeutic benefits to the skin through exosomes, with potential applications in anti-aging treatments.

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A composition containing fibroblast-derived extracellular vesicles for treating skin and mucosal wounds. The composition can be applied topically to accelerate wound healing. The fibroblast-derived extracellular vesicles promote wound healing by enhancing cell proliferation, migration, angiogenesis, and collagen deposition. The composition provides a rapid and effective therapeutic option for skin and mucosal wounds compared to conventional mesenchymal stem cell-derived extracellular vesicles.

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A gel cosmetic that combines mesenchymal stem cell exosomes with skin repair components to address skin concerns. The gel contains exosomes derived from mesenchymal stem cells, which are highly effective in skin repair, possess low immunogenicity, and are non-irritating. The exosomes enhance skin barrier function, promote transdermal absorption, and exhibit anti-inflammatory and antibacterial properties. The gel also incorporates moisturizing agents like glycerin, hyaluronic acid, and ceramide to enhance skin hydration and protection. This innovative gel addresses the limitations of existing skin repair products by combining the potent skin repair benefits of exosomes with comprehensive moisturizing and barrier-enhancing properties.

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Exosomes secreted by human umbilical cord mesenchymal stem cells (UC-MSCs) that enhance skin barrier repair through targeted regulation of epidermal cell function. These exosomes specifically up-regulate miR485-5p expression in epidermal cells, leading to enhanced proliferation and migration capabilities. This targeted approach enables more efficient and effective skin repair compared to conventional MSC-derived exosomes, with potential applications in dermatological treatments.

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A method for preparing cell exosomes for skin repair that enhances their therapeutic efficacy. The method involves preparing exosomes from different cell sources, including mesenchymal stem cells, adipose-derived stem cells, and endometrial stem cells, and then engineering them with specific therapeutic peptides. The engineered exosomes, particularly those containing decapeptide-12, are then purified and concentrated to produce a high-quality exosome concentrate. This engineered exosome preparation combines the beneficial properties of multiple cell sources with targeted therapeutic peptides, enabling faster and more effective skin repair compared to conventional exosome preparations.

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Composition containing exosomes derived from human adipose-derived stem cells induced by autophagy. The exosomes are isolated from stem cell culture media after autophagy induction using methods like nutrient deprivation, osmotic pressure control, and biogenic amine treatment. The composition can be used in cosmetics and pharmaceuticals. The autophagy induction enhances exosome yield and activity compared to natural exosomes. The exosomes have improved wound healing and cell proliferation properties when isolated from autophagy-induced stem cells.

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Engineered exosomes for promoting skin tissue repair through targeted delivery of collagen and growth factors. The exosomes are engineered to selectively deliver specific growth factor genes and type I collagen mRNA to damaged skin cells, facilitating enhanced collagen synthesis and tissue repair. The exosomes are prepared through a novel gene expression vector system that enables precise targeting of specific growth factor and collagen genes, while maintaining their exosomal structure and function.

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Stem cell-derived exosome composition for epidermal repair to improve skin health. The composition contains exosomes derived from human adipose-derived mesenchymal stem cells, along with extracts from Rehmannia glutinosa, Ligusticum chuanxiong, and Fangfeng root. The exosomes are prepared from cultured stem cells, and the extracts are dissolved in solvent. The composition also includes a freeze-dried composite gel made from collagen and sodium hyaluronate. The exosomes, extracts, and gel are combined to create a skin repair formulation.

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Preparation method for iPSC-derived exosomes that enhances skin repair through stable and potent exosomal delivery. The method involves culturing induced pluripotent stem cells (iPSCs) in a specific medium, followed by exosome isolation and purification. The purified exosomes are then formulated with hydroxyethyl cellulose, glycerol, polyethylene glycol, and sorbic acid, and are used as a repair agent for skin injuries. The exosomes contain stem cell-derived exosomes that promote fibroblast proliferation, inhibit scar formation, and improve tissue regeneration. The formulation maintains its therapeutic efficacy over time, making it a valuable tool for skin repair applications.

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Exosomes derived from human dermal fibroblast (HDF) spheroids, which can be generated through 3D cell culture, provide a novel therapeutic approach for treating skin conditions by modulating dermal fibroblast function. These exosomes contain engineered proteins that enhance collagen synthesis, suppress matrix metalloproteinases, and regulate cell signaling pathways, effectively restoring dermal integrity and collagen production in photoaged skin. The exosomes can be administered directly to the skin or used in combination with conventional treatments to deliver therapeutic benefits.

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Wnt4/YWHAZ co-modified mesenchymal stem cell-derived exosomes for diabetic wound healing. The exosomes contain Wnt4 and YWHAZ proteins, which are selectively overexpressed in MSC-derived exosomes. These modified exosomes exhibit enhanced wound healing capabilities compared to unmodified exosomes in diabetic animal models, particularly in promoting epidermal regeneration and tissue repair. The exosomes' enhanced therapeutic potential stems from their ability to selectively deliver Wnt4 and YWHAZ to the wound site, where they promote cellular differentiation and tissue regeneration.

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Composition for inducing mesenchymal stem cells to release specific functional exosomes that promote skin epithelial cell differentiation and its application technical field.

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A synergistic mixture of umbilical cord mesenchymal stem cell exosomes and growth factor-rich CGF for enhanced skin repair. The exosomes contain a balanced mix of growth factors, white blood cells, and other cellular components that promote tissue regeneration, while CGF provides a potent growth factor that directly stimulates cellular proliferation. By combining these components, the mixture enables accelerated skin repair through coordinated action of the exosomes and CGF, bypassing the limitations of exosome alone. The exosomes and CGF work together to restore tissue integrity, with the exosomes facilitating cell-to-cell communication and the CGF promoting cellular differentiation and proliferation.

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A method for preparing exosomes from umbilical cord mesenchymal stem cells using tangential flow ultrafiltration, enabling large-scale production of exosomes with enhanced physiological activity. The method leverages ultrafiltration technology to concentrate exosomes from cell culture media, achieving high purity and scalability while maintaining their biological activity. The exosomes are then used to enhance wound healing by promoting cell proliferation, inhibiting apoptosis, and improving migration, particularly in damaged skin cells exposed to oxidative stress.

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Cosmetic composition and technology that harnesses CD200-modified mesenchymal stem cell exosomes to enhance skin health and delay aging. The composition incorporates CD200-modified mesenchymal stem cell exosomes, which contain the anti-inflammatory cytokine CD200, to promote skin cell viability, metabolism, and repair. By targeting immune suppression pathways, these exosomes improve skin barrier function and reduce inflammation, ultimately contributing to delayed skin aging.

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Exosomes derived from human induced pluripotent stem cells (iPSCs) that enhance skin regeneration and anti-aging through targeted delivery of therapeutic factors. These exosomes, engineered to have specific size and charge characteristics, contain molecules that promote fibroblast proliferation, migration, and collagen synthesis, while reducing matrix metalloproteinase expression. The exosomes can be incorporated into cosmetic formulations to deliver these beneficial factors to the skin, providing a novel approach to skin rejuvenation and wound healing.

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Using engineered exosomes derived from stem cells to promote skin regeneration and repair of diabetic foot ulcers. The exosomes are loaded with genes that stimulate blood vessel regeneration to address the vascular issues in diabetic foot ulcers. This synergistic combination of stem cell-derived exosomes and vascular regeneration genes promotes wound healing in diabetic foot ulcers by repairing the damaged blood vessels.

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Human umbilical cord mesenchymal stem cell-derived exosomes with anti-aging and skin elasticity-enhancing properties. The exosomes are engineered to target specific molecular pathways involved in skin aging and elasticity, and are delivered through a phenyl-gamma-pyranone derivative. The exosomes contain active stem cell-derived exosomes that can be used to treat skin conditions by promoting collagen production and maintaining skin elasticity.

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Human umbilical cord mesenchymal stem cell-derived exosomes with specific anti-aging and skin elasticity effects, developed through the use of phenyl-gamma-pyranone derivatives. These exosomes are derived from hUC-MSCs and contain therapeutic properties that counteract skin aging and improve skin elasticity. The exosomes contain proteins, mRNA, and miRNA from hUC-MSCs, which are transferred to target cells, influencing cellular behavior and tissue regeneration. The exosomes loaded with phenyl-gamma-pyranone derivatives exhibit enhanced anti-aging and skin elasticity effects compared to other exosomes, making them promising therapeutic agents for skin rejuvenation.

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Composition rich in adipose stem cell exosomes for wound healing and tissue regeneration, comprising exosomes derived from adipose-derived mesenchymal stem cells (ASMCs) that exhibit enhanced wound repair capabilities compared to conventional exosomes. The composition contains exosomes with specific concentrations of growth factors, growth factors, and other bioactive molecules that promote tissue regeneration. The exosomes are isolated from adipose tissue-derived mesenchymal stem cells that have been induced to differentiate into mesodermal cells. The composition is characterized by its high concentration of exosomes with specific growth factor profiles that enhance wound healing and tissue regeneration.

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Stem cell exosomes for wound healing that selectively target and reduce myofibroblast and collagen expression in wound tissue. The exosomes contain specific proteins and molecules that selectively target and degrade myofibroblasts and collagen-producing cells, while preserving the wound's natural tissue architecture. This targeted approach enables controlled wound healing by selectively eliminating pathogenic cells while maintaining the wound's structural integrity.

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A skin repair composition and its application that utilizes mesenchymal stem cell exosomes as a protective agent. The composition contains freeze-dried mesenchymal stem cell exosomes that contain specific growth factors and proteins, including fibronectin, vascular endothelial growth factor, fibroblast growth factor, epithelial growth factor, hepatocyte growth factor, transforming growth factor, sphingosine, and ceramide-1-phosphate. These exosomes are derived from mesenchymal stem cells and are used to protect the skin from environmental stressors and promote tissue repair. The exosomes can be incorporated into topical formulations for skin repair and anti-aging applications.

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Using stem cell-derived exosomes and/or extracellular vesicles to improve skin barrier function. The exosomes and vesicles isolated from stem cell culture media can be used as active ingredients in compositions like pharmaceuticals, cosmetics, and skin treatments. They strengthen the skin barrier and improve barrier function without side effects compared to traditional moisturizers or steroids. The isolated exosomes/vesicles have uniform size and high purity. They promote skin barrier function by reducing inflammation and increasing hyaluronic acid synthesis.

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Exosomes enriched with growth factors from stem cells cultured in a medium containing EGF and/or FGF, which are used to enhance skin regeneration and anti-aging effects. The exosomes contain a diverse array of growth factors, including EGF, FGF, and others, which are secreted by stem cells in a medium supplemented with these growth factors. The exosomes are isolated from the stem cell culture and have been shown to contain significantly higher levels of growth factors compared to those from stem cells cultured in a medium without these growth factors.

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Using exosomes derived from human pluripotent stem cells to treat wounds in elderly patients by rejuvenating endothelial cells. The exosomes improve endothelial cell function and reduce senescence. They activate the Nrf2 signaling pathway to reduce oxidative stress and promote angiogenesis. This could help repair wounds in elderly people with impaired healing due to aging of their blood vessels.

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A novel wound dressing combining human stem cell-derived exosomes with medical-grade hyaluronic acid for enhanced skin repair. The exosomes, derived from human adipose tissue, contain active factors that promote vascularization and tissue regeneration. When combined with hyaluronic acid, the exosomes enhance wound healing by facilitating microvessel formation and collagen fiber organization. The resulting complex provides a biocompatible scaffold for tissue regeneration, with superior wound closure rates compared to traditional wound dressings.

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Stem cell exosomes that can repair skin, prepared by transducing decapeptide-12 into mesenchymal stem cells, and their application in cosmetic and medicinal treatments. The exosomes contain decapeptide-12, a potent inhibitor of melanin production, which is delivered to skin cells through exosomes. This approach enables targeted repair of sunburned skin by inhibiting melanin synthesis while preserving skin barrier function.

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Exosome secreted by human umbilical cord mesenchymal stem cells with a diameter of about 100 nm promotes skin damage repair through paracrine signaling. The exosome, extracted from these stem cells, contains complex proteins and microRNAs that facilitate wound healing by enhancing cell proliferation, migration, and tissue regeneration. This exosome can be stored for over a year and has shown therapeutic efficacy in treating skin lesions and burns, particularly in deep and full-thickness wounds.

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Exosomes derived from mesenchymal stem cells that enhance wound healing by promoting epidermal cell proliferation and tissue regeneration. The exosomes contain specific growth factors that synergistically stimulate cell proliferation and differentiation, while also facilitating tissue repair. The exosomes are delivered in a spray format to facilitate precise dosing and control, allowing clinicians to target specific wound areas for enhanced healing outcomes.

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A kit for preparing a medicament that combines exosomes and cytokines to enhance wound healing. The kit contains exosomes derived from mesenchymal stem cells, along with specific concentrations of basic fibroblast growth factor and epidermal growth factor. These exosomes and cytokines work synergistically to promote epidermal cell proliferation and regeneration, facilitating the repair of full-thickness skin lesions. The exosomes can be prepared by culturing mesenchymal stem cells in a defined growth medium, while the cytokines are added to the culture medium. The resulting exosome-cytokine complex can be delivered as a spray for localized wound treatment.

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Extracellular vesicles (EVs) derived from adipose tissue that contain therapeutic agents, particularly microvesicles and exosomes, are isolated from liposuction fluid. These EVs, which retain their cellular structure and function, are engineered to target specific cells or tissues through selective expression of cell surface proteins. They can be loaded with therapeutic agents, including drugs, peptides, and nucleic acids, and delivered directly to target cells or tissues, offering a novel approach for targeted drug delivery and tissue regeneration.

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A cream for external application that utilizes exosomes derived from human mesenchymal stem cells to promote skin regeneration and rejuvenation. The exosomes contain specific growth factors and proteins that stimulate cellular proliferation, differentiation, and tissue repair in the epidermis and dermis. The cream is applied directly to the skin surface, where it interacts with stem cell-derived exosomes to deliver targeted therapeutic signals. This approach enables sustained delivery of growth factors and cellular components to the skin's surface, promoting tissue repair and regeneration while maintaining skin health.

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Topical compositions containing stem cell-derived exosomes for regulating skin condition and repairing soft tissue damage. The exosomes are isolated from stem cell cultures that undergo a heat shock treatment. The heat shock increases the levels of heat shock stress-response molecules like HSP70 in the exosomes. These exosomes have enhanced proliferative and anti-inflammatory activity when applied topically to repair skin damage, reduce wrinkles, and improve skin health. The compositions can be used in creams, lotions, gels, or powders for skin care applications.

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