Malassezia Biofilm Disruption Using Natural Plant Extracts for Scalp Care
Malassezia species form complex biofilms on human skin, particularly in sebum-rich areas like the scalp. These fungal communities secrete extracellular polymeric substances that shield cells from conventional treatments, with mature biofilms showing resistance levels up to 1000-fold higher than planktonic cells. Clinical measurements show that Malassezia-associated conditions persist despite treatment in 40-60% of cases, largely due to biofilm-mediated protection mechanisms.
The challenge lies in developing compounds that can penetrate biofilm matrices while maintaining antimicrobial efficacy without disrupting the beneficial scalp microbiome.
This page brings together solutions from recent research—including synergistic essential oil blends with tea tree and bergamot components, plant extract formulations featuring Magnolia officinalis bark, and compositions that combine targeted anti-fungal properties with oil regulation mechanisms. These and other approaches focus on practical therapeutic applications that address both biofilm disruption and underlying scalp conditions while maintaining safety profiles suitable for regular use.
1. Compound Essential Oil Blend with Specific Ratio of Cypress Leaf, Tea Tree, Bergamot, and Jasmine Essential Oils
JIANGXI RUIXIULANG TECHNOLOGY CO LTD, Jiangxi Ruixiulang Technology Co., Ltd., 2024
A compound essential oil for controlling oil and promoting hair growth, comprising cypress leaf essential oil, tea tree essential oil, bergamot essential oil, and jasmine essential oil in a specific ratio, which exhibits synergistic therapeutic effects for scalp health.
2. Essential Oil Composition with Platycladus Orientalis, Tea Tree, Bergamot, and Jasmine for Scalp Penetration
JIANGXI RUIXIULANG TECH CO LTD, 2024
A compound essential oil for treating scalp diseases that effectively controls greasiness and promotes hair growth. The oil, derived from a combination of Platycladus orientalis, tea tree, bergamot, and jasmine essential oils, exhibits potent anti-dandruff and anti-hair loss properties. It achieves this through synergistic action on sebaceous glands and hair follicles, with its molecular weight below 500 Dalton facilitating penetration into the skin layers. The oil's composition and formulation enable targeted delivery of its active components to the scalp while minimizing irritation, making it suitable for clinical use.
3. Natural Oil Composition with Lemon, Orange, and Geranium Oils
Korea Kolmar Co., Ltd., KOLMAR KOREA CO LTD, 2024
A natural oil composition for preventing hair loss and promoting hair growth that is safe and effective. The composition contains lemon oil, orange oil, and geranium oil. It can be used in cosmetics, skin care products, pharmaceuticals, and quasi-drugs to prevent, improve, prevent, or treat hair loss, or promote hair growth. The natural oils have antibacterial properties against harmful scalp bacteria, which improves scalp microbiome health. This composition prevents hair loss while being harmless to the body and provides a significant improvement compared to conventional hair loss treatments.
4. Composition with Magnolia Officinalis Bark Extract, Panthenol, and Guar Gum Hydroxypropyltrimonium Chloride for Hair and Scalp Care
SHANGHAI ZHONGYI DAILY CHEMICAL CO LTD, 2023
A soothing and oil-controlling composition for washing and care products like shampoo, conditioner, and scalp essence. The composition contains plant extracts like Magnolia officinalis bark extract, moisturizers like panthenol, and conditioning agents like guar gum hydroxypropyltrimonium chloride. The plant extract provides anti-inflammatory, antioxidant, and antimicrobial benefits. The moisturizer prevents dryness and flakiness. The conditioner adds body and reduces static. The combination provides scalp health benefits like reducing dandruff, repairing barrier function, and relieving itching. It also reduces greasiness and improves appearance.
5. Composition of Synergistically Compounded Plant Extracts with Antifungal Properties and Preparation Method
GUANGZHOU BAOYI BIOLOGICAL TECH CO LTD, 2023
A plant oil control anti-dandruff composition and preparation method that combines the benefits of natural oils with potent antifungal properties. The composition comprises synergistically compounded plant extracts, including Salvia miltiorrhiza, cinnamon bark, blue branch and leaf, camphor leaf, purple Grass roots, Magnolia officinalis bark, lilac, centella asiatica leaves, and aloe vera leaves, which synergistically enhance oil control and dandruff removal while maintaining a gentle scalp safety profile.
6. Composition of Tea Tree Oil, Green Thorn Fruit Oil, and Lavender Oil in Specific Mass Ratio for Antibacterial and Anti-Inflammatory Effects
GUANGZHOU SIFEN COSMETICS CO LTD, 2023
Composition for treating dandruff and scalp irritation through the synergistic antibacterial and anti-inflammatory effects of tea tree oil, green thorn fruit oil, and lavender oil. The composition combines these essential oils in a specific mass ratio to create a potent anti-dandruff and anti-itch agent that addresses the underlying causes of scalp conditions. The oils' unique interactions provide a balanced and effective solution for both fungal and inflammatory components of dandruff and scalp irritation.
7. Hair Care Composition with Yellow Lily, Lavender, Indian Gooseberry, and Peppermint Extracts
Newgen Cosmetic, NEWGEN COSMETICS, 2022
Hair care product using a natural plant extract to improve scalp health and prevent hair loss. The extract is made from a combination of extracts from yellow lily, lavender, Indian gooseberry, and peppermint. The extracts are prepared separately and then mixed. The extract contains compounds that promote scalp cell regeneration, hair growth, and cytokine production to combat hair loss. The extract is used in hair care products like shampoo and conditioner to provide scalp benefits and prevent hair loss.
8. Composite Shampoo Formulation with Zinc Pyrithione and Plant Extracts Featuring Synergistic Anti-Dandruff Mechanism
GUANGZHOU YANGSEN PHARMACEUTICAL CO LTD, 2021
A composite anti-dandruff shampoo that combines the anti-dandruff properties of plant extracts and traditional anti-dandruff agents to create a synergistic effect. The shampoo combines zinc pyrithione with other ingredients like plant extracts, surfactants, and emulsifiers to enhance its anti-dandruff properties while addressing scalp aging and oil secretion. This combination provides improved scalp repair, exfoliation, and oil removal, while maintaining the safety profile of traditional anti-dandruff ingredients.
9. Formulation Comprising Citrus, Tea, and Spice Extracts with Essential Oils for Biofilm Inhibition
MOTILAL NEHRU NATIONAL INSTITUTE OF TECHNOLOGY ALLAHABAD, 2021
A formulation for preventing and treating bacterial biofilms that combines extracts of citrus, tea, and spices with antimicrobial properties. The formulation achieves effective biofilm inhibition through extracts of citrus lemon, camellia sinensis, terminalia arjuna, terminalia chebula, phyllanthus emblica, and essential oils like oregano, thyme, and cinnamon, in a single, non-additive formulation. The extracts and essential oils exhibit broad-spectrum antimicrobial activity, including biofilm-specific mechanisms, while the formulation maintains a natural, non-inhibitory composition.
10. Cosmetic Composition with Zinc Pyrithione, Melaleuca Alterniflora Oil, Carbohydrate Isomers, Caprylylglycine, and Blue Eucalyptus Oil
GUANGZHOU UNIASIA COSMETICS TECHNOLOGY CO LTD, 2021
Oil control and anti-dandruff composition for cosmetics like shampoo. The composition contains zinc pyrithione, Melaleuca alterniflora leaf oil, carbohydrate isomers, caprylylglycine, and blue eucalyptus oil. Zinc pyrithione prevents dandruff and fungi, Melaleuca oil is antibacterial, carbohydrates moisturize, caprylylglycine regulates oil, and blue eucalyptus oil soothes and antioxidizes. The composition balances oil control, anti-dandruff, and scalp health without harshness.
11. Shampoo Composition with Tea Tree Essential Oil and Extract Featuring Terpene-4-ol and Zinc Pyrithione
MAYWUFA COMPANY LTD, 2020
A dual-action shampoo containing tea tree essential oil and extract that provides comprehensive dandruff and antibacterial benefits. The composition combines the potent antibacterial properties of terpene-4-ol (4-Carvomenthol) with the natural antifungal and anti-inflammatory properties of tea tree extract, creating a synergistic effect that effectively controls both dandruff and acne. The formulation is specifically designed for shampoo applications, with a balanced concentration of 0.05% to 2% tea tree essential oil and 0.01% to 1% tea tree extract, along with added zinc pyrithione and clomiprazole for enhanced anti-dandruff efficacy.
12. Biofilm Dispersion Composition with 3,6-Dimethyl-2-Heptanol, Linalool, and Ethyl Linalool Targeting Staphylococcus Capitis
KAO CORP, 2019
A biofilm dispersion remover for scalp odor reduction that targets the specific biofilm formed by Staphylococcus capitis bacteria. The remover contains specific fragrance materials derived from 3,6-dimethyl-2-heptanol, linalool, and ethyl linalool, which are highly effective against biofilms formed by S. capitis. The remover can be incorporated into shampoos or other hair care products to effectively break down and eliminate the biofilm responsible for scalp odor.
13. Essential Oil Blend with Specific Ratios of Rosemary, Geranium, Lavender, Sandalwood, Ylang-Ylang, Lemon, Eucalyptus, Patchouli, and Sage
ANHUI XIANGJIE ESSENCE TECH CO LTD, 2017
A natural essential oil blend for treating oily scalp that contains rosemary, geranium, lavender, sandalwood, ylang-ylang, lemon, eucalyptus, patchouli, and sage essential oils in specific ratios. The blend aims to provide a purely natural and side effect-free alternative to chemical-containing oily scalp products. The essential oils have properties like increasing hair growth, reducing oil production, soothing inflammation, and bactericidal effects. The ratios of each oil were optimized to balance their properties and create an effective blend for oily scalp.
14. Composition of Essential Oils and Zinc Pyrithione with Specific Weight Percentages
LAF JAHWA CO LTD, 2016
A synergistic composition for treating head and shoulder conditions like dandruff that combines essential oils with zinc pyrithione. The composition contains zinc pyrithione at 2-20% weight, essential oils at 5-15% weight, dispersant at 0.3%, water at 63-93% weight, and optional ingredients like surfactants, conditioners, thickeners, and preservatives. The essential oils can be a blend like cypress, lavender, eucalyptus, tea tree, rosemary, pheasant pepper, peppermint, juniper, thyme, cinnamon, clove, patchouli, oregano, sage, lemongrass, mugwort, and azusa lemon.
15. Hair Care Formulation with Synergistic Plant Extract and Essential Oil Emulsion
WANNAN MEDICAL COLLEGE, 2016
A natural anti-dandruff hair care product that effectively manages scalp conditions through a synergistic combination of plant extracts and essential oils. The formulation combines a blend of mineral-rich oils, including jojoba oil, rosehip oil, and lavender oil, with plant-based ingredients like honeysuckle extract and ginger, which possess anti-inflammatory and antimicrobial properties. The unique blend of natural ingredients creates a stable emulsion that maintains balance between oil and water levels, preventing scalp irritation and promoting healthy scalp conditions.
16. Skin Cleansing Composition with Alkylammonium Salt Surfactant Blend for Biofilm Disruption
KAO CORP, 2016
A skin cleansing composition that effectively removes biofilms of microorganisms and microbial substances from the skin surface while maintaining skin comfort. The composition employs a unique surfactant blend of alkylammonium salts with specific molecular weights and charges, particularly containing positively charged basic amino acids, to selectively target and degrade biofilm-forming microorganisms. The composition is hypoallergenic and non-irritating to the skin, making it suitable for patients with sensitive skin conditions.
17. Shampoo Composition with Herbal Extracts and Essential Oils for Scalp Balance
SUN REN, 2016
A natural, gentle shampoo that effectively manages dandruff through a multi-component approach. The shampoo combines a blend of herbal extracts, including leather whistle, Oriental Arborvitae, Salvia, Angelica, and Polygonum, with essential oils like cinnamon, orange peel, clove, and turmeric. This proprietary blend addresses the underlying balance of the scalp's ecological environment, maintaining healthy oil production and controlling fungal growth. The natural ingredients provide a soothing, non-irritating formula that addresses the root causes of dandruff without causing side effects.
18. Topical Composition with Essential Oils and Botanical Extracts in Shea Butter Carrier
GR8 ORGANICS INC, 2016
A composition for topical application that combines natural anti-inflammatory and antimicrobial agents to treat skin conditions. The composition comprises a blend of essential oils, including peppermint, lavender, hempseed, and clove, along with a proprietary blend of botanical extracts, including calendula, hops, and red clover. The composition is formulated as a cream or lotion, with a carrier of shea butter for enhanced moisturizing properties. The combination provides potent anti-inflammatory and antimicrobial effects, making it suitable for treating eczema, scalp irritation, and insect bites.
19. Biofilm Remover Composition with Long-Chain Internal Olefin Sulfonate and Controlled Sulphonic Acid Positioning
KAO CORP, 2015
Biofilm remover composition for human body that selectively targets and removes biofilms while minimizing skin irritation. The composition contains a specific type of internal olefin sulfonate with a carbon chain length of 16 or more and a sulphonic acid group at the 1-position, with a concentration of olefin sulfonate at the 1-position of the carbon chain being 20% or less. This composition achieves both high biofilm removal efficacy and low stratum corneum swelling property, enabling effective penetration into the skin while minimizing damage to the skin barrier.
20. Essential Oil Blend with Olive and Jojoba Oils for Scalp Care Containing Lavender and Tea Tree Oil
QINGDAO YONGTONG ELEVATOR ENGINEERING CO LTD, 2015
Antipruritic and dandruff of hair essential oil for scalp care, particularly for managing scalp irritation and flaking. The oil formulation comprises a blend of essential oils, with a primary component being a blend of olive oil and jojoba oil, along with other natural ingredients like lavender and tea tree oil. The blend is designed to provide effective anti-pruritic and anti-dandruff properties through its moisturizing, anti-inflammatory, and antifungal properties, while also promoting healthy scalp conditions.
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