Collagen Production Techniques for Skin Rejuvenation
20 patents in this list
Updated:
Modern collagen production techniques aim to address the natural decline in skin collagen—approximately 1% per year after age 20—which leads to decreased skin elasticity and increased formation of fine lines. Clinical measurements show that intrinsic and extrinsic aging can reduce dermal collagen density by 20-80% depending on anatomical location and environmental exposure.
The fundamental challenge lies in developing bioavailable compounds that can effectively penetrate the stratum corneum while maintaining stability and triggering sustained collagen synthesis in the dermis.
This page brings together solutions from recent research—including peptide-modified siloxane carriers, low-molecular-weight collagen peptides with specific tripeptide ratios, bioactive compounds combined with supramolecular ionic liquids, and probiotic-enhanced collagen formulations. These and other approaches focus on improving both the immediate and long-term collagen synthesis response while maintaining formulation stability and skin compatibility.
1. Double-Helix Collagen Composition with Biodegradable Polymers and Active Peptides
SUZHOU XINGYANHUI MEDICAL HEALTH TECH CO LTD, 2023
A double-helix structure regenerative double-effect human-like collagen composition for medical and aesthetic injections that provides long-lasting collagen regeneration and skin rejuvenation. The composition contains biodegradable polymers, collagen, organic acids, small molecule active peptides, sodium alginate, and water. The biodegradable polymers provide sustained release of lactic acid to stimulate collagen synthesis, while the collagen provides immediate collagen replacement. Organic acids and peptides enhance collagen production.
2. Anti-Wrinkle Composition with Peptides and Supramolecular Ionic Liquids
SHENZHEN SHANHAI INNOVATION TECH CO LTD, 2023
An anti-wrinkle composition and cosmetics that provide both immediate and long-acting wrinkle removal, restore skin elasticity, and have good penetration and bioavailability. The composition contains peptides like snake venom peptide, conus peptide, and acetyl tetrapeptide-2, along with supramolecular ionic liquids like betaine glycerol and glycerol glucoside. These ingredients work together to instantly smooth wrinkles and promote collagen production for long-lasting anti-wrinkle effects. The composition can be used in cosmetics like essences, emulsions, creams, masks, etc.
3. Cosmetic Composition with Hydrolyzed Collagen, Arginine/Lysine Peptides, and Ethylbisiminomethylguaiacol Manganese Chloride
AOTING BIOTECHNOLOGY CO LTD, 2023
Anti-wrinkle and firming composition for cosmetics containing hydrolyzed collagen, arginine/lysine peptides, and ethylbisiminomethylguaiacol manganese chloride. The composition provides more effective skin firming, wrinkle reduction, and anti-oxidation compared to conventional anti-wrinkle products. The composition can be used in cosmetics like masks and creams. The hydrolyzed collagen increases collagen production, arginine/lysine peptides relax muscles, and ethylbisiminomethylguaiacol manganese chloride has antioxidant properties.
4. Cosmetic Composition with Specific Low-Molecular-Weight Collagen Peptides and Defined Tripeptide Content
NEW TREE CO LTD, 2022
Cosmetic composition containing low-molecular-weight collagen peptides for improving skin wrinkles, antioxidant, moisturizing, whitening, anti-inflammatory, anti-glycation and skin aging inhibition. The composition contains collagen peptides with a specific composition of 0.5-10% Gly-Pro-Hyp tripeptide (GPH) and 15-40% tripeptide content compared to the total hydrolyzate. This composition improves skin health by promoting collagen synthesis, reducing glycation, and inhibiting oxidative stress.
5. Collagen Peptide Skin Care Composition with Plant Extracts, Vitamin E, Humectants, Glycerin, and Nano-Titanium Dioxide
HAINAN HUAYAN COLLAGEN TECH CO LTD, 2022
Collagen active peptide skin care composition that penetrates into the inner layers of the skin to provide effective anti-aging benefits. The composition contains specific concentrations of collagen peptides, plant extracts, vitamin E, humectants, glycerin, and nano-titanium dioxide. The composition aims to improve skin elasticity, reduce wrinkles, fade dark spots, and protect against environmental stressors. The composition is prepared by mixing the ingredients in specific proportions.
6. Peptide-Infused Composition with Collagen Derivatives and Hyaluronic Acid
GUANGZHOU UNIASIA COSMETICS TECH CO LTD, 2022
Peptide-containing composition for anti-aging cosmetics that promotes synthesis of m-type collagen in the skin to improve anti-aging ability. The composition includes collagen or its derivatives, peptides, and hyaluronic acid. It aims to combat skin aging in all directions by promoting collagen production, resisting free radicals, shrinking pores, and relieving aging inflammation. The composition can be applied in cosmetics like creams and lotions.
7. Tetrapeptides Comprising D-Amino Acids for Serine Protease Inhibition and Enhanced In Vivo Stability
ESPIKEM S R L, 2022
Bioactive peptides for preventing and treating signs of skin aging like wrinkles, fine lines, loss of firmness and elasticity. The peptides are tetrapeptides made of D-amino acids (Dasn-Dval-Dval-Dlys) that inhibit serine proteases involved in collagen degradation. The D-amino acid peptides have surprising protective activity against collagen degradation compared to L-amino acid peptides. They also have higher in vivo stability to maintain collagen protection over time. The D-amino acid peptides are useful as active ingredients in cosmetic compositions to prevent and treat signs of skin aging.
8. Composition Comprising Collagen and Elastin Peptides with Botanical Extracts
GUANGDONG SIRRAH BIOTECHNOLOGY CO LTD, 2022
Composition for anti-wrinkle, moisturizing, and improving skin elasticity that contains collagen peptides, elastin peptides, hyaluronic acid, salmon nasal cartilage composite powder, red pomegranate extract, olive fruit extract, grape seed extract, and German chamomile flower extract. The composition can be prepared by extracting red pomegranate, olives, and grape seeds, then mixing them with the other ingredients.
9. Cosmetic Composition with Peptides, Eosangcho, and Artemisia Wormwood Extract for Collagen Synthesis Promotion
CELLICON LAB INC, 2021
Collagen synthesis promoting cosmetic composition for skin improvement. The composition contains a mixture of peptides, Eosangcho (Herba Houttuyniae), and Artemisia wormwood extract. This mixture promotes collagen synthesis by increasing procollagen I levels and inhibiting collagen degrading enzymes like MMP-1. It also does not have cytotoxicity. The composition can be used in cosmetics to improve skin wrinkles by preventing, treating, or improving skin wrinkles when applied to humans.
10. Cosmetic Composition with Hydrolyzed Collagen, Peptides, and Ceramide-3 in Defined Ratios
GUANGZHOU BOYA COSMETICS CO LTD, 2020
Anti-aging wrinkle-removing composition for cosmetics that provides instant wrinkle removal and long-term wrinkle reduction with improved skin elasticity. The composition contains hydrolyzed collagen, peptides, moisturizers, compound amino acids, ceramide-3, polyols, antioxidants, and preservatives in specific ratios. It aims to instantly remove wrinkles and provide lasting anti-aging benefits by rebuilding collagen networks, increasing moisture, enhancing barrier function, brightening skin, and reducing inflammation.
11. Cosmetic Composition with Specific Peptides and Collagen Fermentation Products Containing Hexapeptide-11, Hexapeptide-67 Palmitate, Palmitoyl Pentapeptide-4, Copper Tripeptide-1, Tripeptide-29, and Lactic Acid Bacteria Fermented Collagen
A&F Co., Ltd., A & PEP INC., 2020
Cosmetic composition for reducing skin aging containing a combination of specific peptides and collagen fermentation products. The composition includes at least five active ingredients selected from hexapeptide-11, hexapeptide-67 palmitate, palmitoyl pentapeptide-4, copper tripeptide-1, tripeptide-29, collagen fermentation product, and a mixed fermentation of ice plant and collagen. The peptides inhibit collagenase activity and promote collagen production. The collagen fermentation improves skin elasticity and moisturization. The composition can have 0.005-0.1% peptides and 1-10% collagen fermentation. The collagen fermentation is done with lactic acid bacteria like Lactobacillus.
12. Method for Enzymatic Hydrolysis of Cod Skin Collagen Peptides for Composite Cream Formulation
TINGTING LU, 2020
Preparation method of an anti-oxidation and anti-wrinkle composite moisturizing cream using cod skin collagen peptide as a key ingredient. The method involves enzymatically hydrolyzing collagen from cod skin to obtain the collagen peptides. These peptides are then added to a moisturizing cream formulation along with other ingredients like alkaline protease. The resulting cream provides anti-oxidant, anti-wrinkle, and moisturizing benefits to the skin due to the collagen peptides.
13. Cosmetic Composition with Collagen Peptides, White Freunds Extract, and White Ginseng Polysaccharide
AMOREPACIFIC CORPORATION, Amorepacific Corporation, 2017
Cosmetic composition for skin whitening and lifting that improves skin uniformity, brightness, reduces yellowing and redness, and enhances elasticity. The composition contains at least two types of collagen peptides, white freunds extract, and white ginseng polysaccharide. This combination provides skin benefits like increasing collagen density, inhibiting melanin biosynthesis, and reducing yellowing and redness.
14. Composition Containing Plankton Extract, Fermented Soybean Milk, Retinol Palmitate, Arabidopsis Thaliana, Hydrolyzed Sesame Protein, and Peptides
HUNAN YUJIA COSMETICS MANUFACTURING CO LTD, 2017
Skin firming composition for anti-aging benefits. The composition contains extracts from plankton, a lactobacillus and soybean milk fermentation product, retinol palmitate, VE, arabidopsis thaliana extract, hydrolyzed sesame protein, and peptides. It aims to enhance cell proliferation, metabolism, collagen synthesis, elastin production, and antioxidant protection to improve skin firmness, reduce wrinkles, and delay aging. The composition can be used in cosmetics to firm and rejuvenate the skin.
15. Cosmetic Nutritional Composition with Re-Proportioned Collagen Peptide Powder and Natural Antioxidants
ANHUI WANGRUN BIOTECHNOLOGY CO LTD, 2017
A cosmetic nutritional composition for improving skin health and vitality by re-proportioning collagen peptide powder components and adding natural antioxidants to enhance absorption and effectiveness. The composition contains 85% collagen peptide (average molecular weight 800-2000), 5% grape seed extract, 5% seabuckthorn extract, 4% vitamin C, and 1% vitamin E. The grape seed and seabuckthorn extracts are natural antioxidants that improve collagen absorption and skin health when combined with collagen. The composition aims to provide better skin rejuvenation and anti-aging effects compared to collagen supplements alone.
16. Cosmetic Composition with French Helichrysum Extract, Palmitoyl Tripeptide-5, and Dipeptide Diaminobutyryl Benzylamide Diacetate
GUANGZHOU CHANTS COSMETICS CO LTD, 2016
Collagen-boosting cosmetic composition to resist wrinkles by stimulating collagen production. The composition contains extracts from French helichrysum flowers, palmitoyl tripeptide-5, and dipeptide diaminobutyryl benzylamide diacetate. These ingredients work synergistically to enhance collagen synthesis and improve skin elasticity to reduce wrinkles. The helichrysum extract contains a periostin protein that stimulates collagen formation. Palmitoyl tripeptide-5 mimics thrombospondin-1 to activate TGF-beta for collagen synthesis. Dipeptide diaminobutyryl benzylamide diacetate blocks acetylcholine receptors to relax muscles and prevent wrinkles. The composition also includes common cosmetic formulation components like emollients, preservatives
17. Cosmetic Ingredient Composition with Specific Ratios of Collagen Peptide, Elastin Peptide, and Proteoglycan
SUNTORY HOLDINGS LTD, 2015
A cosmetic ingredient composition that improves skin health using low concentrations of collagen peptide, elastin peptide, and proteoglycan. The composition has a specific ratio of these collagen-related components to effectively improve skin when ingested in lower amounts compared to high collagen doses. This allows demonstrating skin benefits like collagen production, wrinkle reduction, and anti-aging effects with lower collagen intake. The composition promotes fibroblast proliferation, collagen synthesis, and skin anti-aging without high collagen levels.
18. Skin Care Composition with Synthetic Peptide and Low Molecular Weight Hydrolyzed Collagen
KOSE INC, 2011
Anti-aging skin care products that promote collagen production to reduce wrinkles and sagging. The products contain a synthetic peptide of 3-8 amino acids and hydrolyzed collagen with a molecular weight of 500-5000. This combination promotes collagen synthesis in the skin to improve wrinkles and sagging.
19. Cosmetic Composition with Nanoliposomes Stabilized by Low Molecular Weight Collagen Peptides and Eucalyptus Globulus Extract
The Face Shop Korea, THEFACESHOP KOREA CO LTD, 2008
A cosmetic composition to prevent skin aging by promoting collagen synthesis, inhibiting collagen degradation, and improving skin moisture. The composition contains nanoliposomes stabilized with low molecular weight collagen peptides, derived from collagen enzymatic hydrolysis. It also contains extract from Eucalyptus globulus, called Duchong, which promotes collagen synthesis and inhibits collagen degradation. The nanoliposomes improve skin penetration of the collagen peptides, enhancing collagen synthesis and moisture. The Duchong extract synergizes with collagen to prevent wrinkles and improve elasticity. The composition is safe and stable for cosmetic use.
20. Topical Composition with Acylated and Esterified Peptides for Collagen Synthesis Stimulation
HENKEL KGAA, 2006
Topical cosmetic and dermatological compositions for treating mature or intrinsically aged skin, especially for anti-wrinkle effects, by stimulating collagen synthesis. The compositions contain specific peptides along with other ingredients like collagen-stimulating tripeptides, amino acids, nucleotides, and betaine. The peptides include di-, tri-, tetra-, penta-, and hexapeptides that can be acylated and/or esterified. They work by releasing growth factors like TGF-β to stimulate collagen synthesis in dermal fibroblasts via a different mechanism than the tripeptides.
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